Catherine Crofts PhD
1.5K posts




















Kicking off medical clinic engagement in our Reverse T2D research using #wholefood, carb reduction in primary care. @marcushnz @grantsnz @lowcarbGP @PharmacistCath Check our website for details wholenz.org/research-proje…

Muscle is key to optimal cardiometabolic health. Unfortunately, it's a challenge to build and an increasingly difficult challenge to maintain with age. Accordingly, we want to do what we can to keep it. This new report suggests another reason to avoid linoleic acid (from seed oils). The authors find that linoleic acid is metabolized via lipoxygenase into highly reactive peroxides which subsequently damage muscle cells. (Important note: the experimental model is cell cultures. I'm unaware of comparable evidence showing muscle damage with dietary linoleic acid, but it's easy to speculate a similar effect would occur, albeit more modestly.) pubmed.ncbi.nlm.nih.gov/38387137/







Opposite effects of low-carbohydrate high-fat diet on metabolism in humans and mice. The issue with this study, is mice need to have < 2.5% of calories from carbs and extremely low protein too, in order to be in ketosis. So the diet of the mice, although being “high fat” as a percentage (60, 70 or 75%) were actually having the mouse equivalent of donuts every day. Most humans on a 60% to 70% calories from fat diet, where carbs are below 10%, automatically go into ketosis. That means insulin becomes low. When insulin is low, it allows for lipolysis, and beta oxidation as well as ketogenesis and ketolysis. All factors that increase weight loss. In addition, a decrease in insulin, improves leptin sensitivity, which again improves satiety signalling sensitivity. When reading studies with mice, always be aware of the fact that mice have different macronutrient ratios to elicit similar metabolic states as humans. If this is not understood by the scientists designing and conducting their trial, then the results/findings of the study, whilst correct are based on the faulty premise of the study, that giving a high fat diet with low carb to humans, in the same ratios would result in the same effect in mice. pubmed.ncbi.nlm.nih.gov/37950240/








