
🧠 PhD Opportunity: Molecular Neurodegeneration in Human Brain Tissue — KU Leuven
📍 Location: Leuven, Belgium 🇧🇪
🏛️ Department: Imaging & Pathology – Translational Cell and Tissue Research Unit
👩🔬 Supervisor: Prof. Dr. Annelies Quaegebeur
⏳ Deadline: August 17, 2026
📅 Duration: At least 1 year of funding initially, with support to secure PhD fellowship funding for the remainder (start: October 1, 2026)
🧠 About the Project
Glial cells are emerging as a promising therapeutic target in neurodegenerative disease — but their molecular role remains poorly understood. This PhD project investigates the molecular signatures of glia directly in human post-mortem brain tissue affected by Lewy Body pathologies and tauopathies, moving beyond animal and cell models to study disease as it actually unfolds in humans. You'll optimize and apply a novel mass-spectrometry-based spatial proteomics workflow, integrating it with transcriptional profiles and quantitative pathology metrics, in collaboration with KU Leuven's Laboratory of Applied Mass Spectrometry and strong ties to the University of Cambridge.
🧑🔬 Ideal Candidate
- Master's degree in Biomedical Sciences, Medicine, Biochemistry, (Neuro)biology, Cell/Molecular Biology, or related field
- Strong critical thinking and experimental design skills
- Genuine interest in molecular mechanisms of neurodegeneration
- Enthusiasm for learning new technologies and working with human brain tissue
- Good written and verbal English communication
- Bonus: experience with histology/tissue techniques (IHC, IF, microscopy), mass spectrometry/proteomics, or data analysis tools (Python, R)
✨ Why Apply
- Join a dynamic, well-funded, internationally networked research group with ties to Cambridge
- Gain specialized, highly sought-after expertise working with human brain tissue
- Access unique, deeply phenotyped human brain tissue collections
- Work with cutting-edge spatial proteomics technology and co-supervision from mass spectrometry experts
- High autonomy in experimental design, with flexible scheduling supporting work-life balance
- Structured doctoral training programme with strong professional development support
🏙️ Location Highlight
Leuven is a historic Belgian university town near Brussels, home to one of Europe's leading research universities with strong international research connections.
🔗 More Info
phdscanner.com/opportunities/…
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