Philip Lab

And a big thank you and shout out to @EricSkaar @kh_oliver @VI4Research @bwfund for creating and supporting this great program to bring scientists and artists together!

Check out other @artlab_vandy art at the Vanderbilt Fine Arts Gallery news.vanderbilt.edu/2023/08/23/mol…

Check out VUMC reporter piece on @jjroetman @CIR_AACR paper featuring amazing artwork by senior Halle Borowski @williamandmary created during the @ArtLab_Vandy @VI4Research Summer 2023 program! news.vumc.org/2023/11/17/tum…

We welcome feedback and suggestions, and a big thank you to our colleagues @VUMC_VCI @VUMC_Cancer @VUMCDIsoveries @Vandy_Biomed for all their support! 7/7

We hypothesize that peptide/MHC-TCR affinity may play a role in the divergent antigen-dependent differentiation we observed as self-shared antigens are usually lower affinity. 6/7

Happy to present our latest paper in @CIR_AACR from @jjroetman, the whole @philiplabvandy team and Drs. Youngmin Lee and Ting-Fang Less @VUMCSurgery !

Immune checkpoint blockade (ICB) can unleash T cell responses against tumors but can also cause unwanted toxicity, or immune-related adverse events (irAE), when T cells attack self/shared antigens in non-cancerous tissues. 3/7

@jjroetman developed a unique cancer model in which we could study CD8 T cell responses against tumor-specific antigens and self/shared antigens. 2/7

Happy Halloween🎃🎃🎃from the Dr. Seuss Lab @VUMC_VCI @VUmedicine @VanderbiltU

Congratulations @JeffRathmell @ahasty4 @hasty4 @MakowskiLab @WellenLab! @VUMC_Cancer @VUMC_VCI

@JeffRathmell @KimrynRathmell @americanacad Congratulations @KimrynRathmell! A well-deserved honor for a great physician-scientist, Chair @VUMC_Medicine and role model!

Congrats to @KimrynRathmell for induction to the @americanacad! Action photo of signing the book

Congratulations Andrea!

@JeffRathmell @AmyMajor6 Congratulations Brenna and @AmyMajor6!

@AmyMajor6 Congrats!

Celebrating a successful dissertation defense by, now former, grad student Brenna Appleton, PhD (in white). Congrats and well deserved!!

@acerobed @VUMC_VCI @VUMC_Cancer @JeffRathmell @SchietingerLab We found that E-TAG show evidence of greater inflammation-driven TF (IRFs and STATs, Fig. 5e shows nice TF motif analysis by Paul Zumbo @DBetel), which may induce functional differentiation in E-TAG. There are likely other factors, and we're working is to figure those out.

@acerobed @VUMC_VCI @VUMC_Cancer @JeffRathmell @SchietingerLab The E-TCRTAG were TAG-specific CD8 T cells in Listeria-infected mice, and as these T cells gain effector function, we abbreviated them as E-TCRTAG. The T-TCRTAG are TAG-specific T cells in tumor-bearing mice, and these become dysfunctional.

We are excited to share our work published today in @NatImmunol by @MRudloffMSTP, the whole @PhilipLabVandy team @VUMCDiscoveries, and in collaboration with our fantastic computational biology collaborators @dbetel and his group @WeillCornell. 1/7 nature.com/articles/s4159…