Philipp Frank

NEW Research: Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study. @MikaKivimaki @Philipp_Frank_ @mmjokela @JLindbohm @hammy_oh @epiAgeing @wysscoray Read it here: buff.ly/43bleSM

5/5 📌 In most cases, ageing of one organ increased susceptibility to diseases in multiple organs. 📌 Plasma-based organ age signatures could provide a quick, non-invasive way to improve disease prediction and prevention. @UCLPsychiatry @UCL_IEHC @helsinkiuni

4/5 📌 Faster organ ageing was associated with an increased risk of 30 age-related diseases. 📌 The development of some diseases—such as liver failure, chronic heart failure, and lung cancer—was exclusively associated with accelerated ageing of their respective organ.

1/5 Our latest research published in @LancetDigitalH shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs 👇 #fig2" target="_blank" rel="nofollow noopener">thelancet.com/journals/landi…

Exciting news! Whitehall Study metadata is now searchable on the CLOSER Discovery tool, enhancing access to longitudinal population study datasets. closer.ac.uk/study/whitehal…

Our latest research in @LancetRH_Europe🚨📊 reveals that individuals placed in out-of-home care during childhood have a 51% greater risk of developing cardiovascular disease in adulthood. 💔🩺 @UCL_IEHC @UCLPsychiatry @wellcometrust thelancet.com/journals/lanep…

New paper led by Prof David Batty - findings show that individuals with experience of out-of-home care in childhood have a moderately raised risk of cardiovascular disease in adulthood 📑 Read the study here: sciencedirect.com/science/articl…

Obesity and risk of diseases associated with hallmarks of cellular ageing: a multicohort study by @MikaKivimaki and colleagues: thelancet.com/journals/lanhl…

Our August issue is out! Featuring frailty progression in Burkina Faso, Parkinson's disease prevalence, and more: thelancet.com/journals/lanhl…

Tackling obesity could be key to reducing the burden of age-related diseases and, ultimately, mortality.

🚨 Our latest study in @LancetLongevity shows strong links between obesity and diseases associated with cellular ageing. 📉🧬 #Obesity #Ageing #HealthResearch @UCLPsychiatry @UCL_IEHC thelancet.com/journals/lanhl…

🚨 New Lancet HL study: #Obesity doubles the risk of diseases linked with cellular ageing🧬. Half of the excess mortality in obese individuals is due to these diseases. Other risk factors aren't as strong predictors. #AcceleratedAging #HealthAwareness sciencedirect.com/science/articl…

New study in @LancetRH_Europe by @Philipp_Frank_ explores associations of physical #abuse experienced during childhood & adulthood with a wide range of adult health conditions requiring hospital treatment: sciencedirect.com/science/articl… #mentalhealth #youthmentalhealth #childpsychiatry

The study emphasizes repeated abuse's risks, urging strategies to address this pervasive issue. From societal shifts in norms to enhanced healthcare provisions, comprehensive approaches are needed to support affected individuals and their families.

New Online—2 large prospective cohort studies examine associations between abuse during childhood & adulthood & hospitalizations for various health conditions. Physical & sexual abuse was linked to 22 mental & physical health conditions. thelancet.com/journals/lanep…

🚨 New study @LancetRH_Europe: Exposure to physical and sexual #abuse during early and later stages of life was associated with an increase in hospitalisations related to 22 #diseases. @UCLPsychiatry @UCL_IEHC @UCL_BSH @helsinkiuni @Mental_Elf sciencedirect.com/science/articl…

Most abuse-disease relationships were, at least in part, attributable to elevated depressive symptoms, obesity, and inflammation. Smoking acted as a dominant mediator primarily for behavioural, circulatory, and respiratory conditions.

These individuals had an over 2-fold risk of hospital-treated mental and behavioural disorders, an approximately 1.5 times increased risk of metabolic, haematologic, and respiratory diseases, and an around 1.2 higher risk of inflammatory diseases.