Nikolaos P. Polyzos

MONART study went online first in The Lancet | The largest RCT compared three protocols of endometrium preparation for FET.

@TuongMHo Large RCTs give answers.... Congrats Tuong for the amazing work... As always!

@TuongMHo Another amazing study by a great group. Congrats Tuong and Lan!

Largest RCT on endometrium preparation protocols for FET. We did it.

Results of MONART study will be presented at ESHRE 2024

Are you ready for the 46th International Dexeus Congress? It's happening next week! Join us for 10 scientific sessions, 3 debates, and 2 parallel embryology sessions featuring renowned international experts in Human Reproduction and Embryology. ​ ​lnkd.in/d9qJ24GB

If you are enthusiastic about mitochondria, you know how lit they are🔥Check our review on how they adapt to oocyte development Or else, if you know how cool oocytes are😎, you’d love to see yet another feature that makes oocytes special: mito-plasticity cell.com/trends/endocri…

@bwmol @S_Mastenbroek ...... Unbelievable!... And yes still online 😂

Another good one to start the Saturday Still online sciencedirect.com/science/articl… Courtesy @S_Mastenbroek

Many thanks @Nature for highlighting our recent discovery: nature.com/articles/d4158…

1/ 📢New #paper alert! Ever wondered how mammalian #oocytes deal with protein #aggregation during their prolonged #life? Check it out in our new paper led by @zaffagg3 out today in @CellCellPress: doi.org/10.1016/j.cell… 👇🏽a thread:

@TuongMHo Incredible! Congrats to your team for generating that outstanding research all these years!!

@PolyzosN Final analysis to finish. Manuscript is developing. HRT is the best!

Endometrium preparation for FET: Question answered. Surprised ! beta.clinicaltrials.gov/study/NCT04804…

Thanks #fertilsteril and @drevefeinberg for the great podcast regarding the TTRANSPORT study presentation during #ESHRE2023. Listen from 50:14 onwards to understand the study design the results and the future implications fertilityandsterilityonair.libsyn.com/fertility-and-…

Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? nature.com/articles/d4158…

@RBMOnline @NunoBorges19 @NunoCostaBorge1 @Embryotools @ObGynAdvance @OvertureLife Super work! Well done Nuno and embryotools... Always innovating!

RBMO has published a First! This is a milestone paper that undoubtedly will hasten development of more fully-automated technologies in the IVF laboratory, in turn increasing consistency and efficacy of laboratory procedures. Do not miss this article! doi.org/10.1016/j.rbmo…

Can #testosterone pretreatment make the difference in #poorresponders undergoing #IVF? Large #RCTs give definitive answers! No it doesn't work! Thanks to all collaborators for the great work! 10 centers 4 counties ~300 patients focusonreproduction.eu/article/ESHRE-… #ESHRE2023 #DexeusMujer

@BWH_NHS @arricoomarasamy Amazing scientist and great person. Well deserved Arri!

We're so proud of Prof. Arri Coomarasamy, a much-loved member of our team, who has been awarded an OBE by His Majesty the King in recognition of his work in improving maternal health for families across the world. Congratulations 🌟 Read more: orlo.uk/Vb6ou

Unique experience with great friends in the national congress of the Moroccan Society of Reproductive Medicine #SMMR.

@MicahJHillDO @FertStert @barnhart_kurt Quick recovery Micah!

I love the ⁦@FertStert⁩ family! I am postop day 1 after a 12 hour surgery & Editor in Chief ⁦@barnhart_kurt⁩ is to here to visit me. I am so grateful to work with such an amazing and kind editorial team! Not just brilliant people, but humble and dedicated.⁦

@MaxEzzatiMD @BortolettoMD @NMacklon Completely agree with you Max! We always go for LH + 6.... Better safe than sorry 😁

Thank you Nikolaos - I agree that probably in the majority of patients the window is wide enough to allow some flexibility, but it is also plausible that: 1) some transfer times may be more optimal than others (ESHRE abstract 2020 by Tim Child's group from Oxford): LH+6 compared to LH+7 (45.0% v 29.1%, p< 0.0001 O-168 Natural cycle frozen-thawed embryo transfer (FET): A comparison of outcomes following blastocyst transfer on day six versus day seven after urinary LH surge. M. Noble, J. Craig, A. Bevan, T. Child 2) Conditions such as PCOS, endometriosis, unexplained infertility, advanced maternal age, recurrent pregnancy loss, RIF, etc. may have an impact on the window of receptivity 3) Significant variations in the configuration of LH surge curve, and the subsequent rise in serum P4 level, may have an impact on the timing of receptivity and optimal point of frozen embryo transfer

Question for @BortolettoMD - Do (did) you transfer blastocysts on LH+5 at Cornell? This is an excerpt from your paper on the Length of E2 exposure and pregnancy outcomes in natural cycle FETs

@MaxEzzatiMD @BortolettoMD @NMacklon Sorry for entering late. I would agree with Max. Atypical to transfer LH+5..but take a look at this study by Bartels RBMO 2019 doi.org/10.1016/j.rbmo… The implantation window seems to be wider for most patients...but you may catch the peak 1 day later & sometimes LH+5 may be ok

@BortolettoMD @NMacklon @PolyzosN It’s actually not quite the same, particularly for older women the difference is very notable based on SART 2019 data - maybe older women cannot afford a patio after all

@TuongMHo @research_hope Looking forward to welcoming the results!

Large RCT compares different endometrium protocols for frozen embryo transfer conducted by @research_hope Vietnam. Last patient in expected in December 2022. Excited! clinicaltrials.gov/ct2/show/NCT04…