PriyankaPulla

25.6K posts

PriyankaPulla

PriyankaPulla

@PriyankaPulla

Journalist. Not on Twitter much. https://t.co/6yZC8zHngA

Bangalore Katılım Kasım 2008
406 Takip Edilen26.6K Takipçiler
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
A thread of all social-media mentions of infections associated with Kumbh Mela 2025 visit (1)
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
Media coverage of that study is ridiculous, but what's new? All of it is driven by a wilful misunderstanding of the drug quality problem, a lack of desire to engage with nuances, and an eagerness to find sensationally simplistic answers.
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
Just say: we found generics in our study to have conformed with specs. Why make sweeping claims like "generics are as good as branded", when no one said generics are bad in first place (problem much more nuanced), and no single study can provide evidence for such sweeping claim?
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
In vitro dissolution DOES NOT mimic the release of a drug in a physiological environment a lot of the time. If it was that simple, nobody would ever ask for BE studies. This is such a basic error. Perhaps what led to the conclusions of the study being vastly overstated :-/
TheLiverDoc™@theliverdoc

A few thoughts The generics vs. branded drugs quality study has stirred up a hornet's nest and with it, multi-pronged criticisms... ...mostly from a section of doctors who have been prescribing expensive branded drugs all their lives... ...also from people who, have all their lives believed that generics (especially from Government) was poor quality (based on cherry picked studies, personal experiences, second- and third-hand stories)... ...and also those who are always critical of whatever Government does. Because of this, the whole discussion has now moved into the "regulation of drugs" space, and completely misinterpreted what the Citizens project actually looked at. We looked at the same medicine (single batch, 22 different types, based on 8 therapeutic categories) from different sources for non-inferior pharmaceutical quality, as prescribed by national standards. Batch-to-batch variation was not our objective (we can take this up in the future with larger funding). The study does not claim to fix the regulatory system; it claims to test the product the patient holds in their hand. The data shows those products were not inferior to similar expensive brands. The study was on "quality assurance" which relies on established scientific standards and protocols. It was not on why we have different regulations and why we should improve regulations - this is a different argument. We have shown independently, that commonly prescribed generics were good enough as the branded counterparts. The testing was done as per IP 2022 standards. There is no other methodology apart from what the standards warrant. Clarifying a common argument here in brief: For example in-vitro dissolution is the internationally accepted quality control standard (USP, BP, IP) precisely because it mimics the release of the drug in the physiological environment. Asking for in-vivo on top of this is "crass argument." On the question of in-vitro in-vivo correlation, for many drug classes, particularly those we tested, there is a robust, scientifically proven correlation between how a drug dissolves in the lab and how it is absorbed in the body. Dismissing this fundamental tool of pharmaceutical science ignores decades of evidence that links dissolution profiles to clinical performance. Due to a hectic clinical schedule, teaching programs, research writing and meetings, I was unable to prepare the final summary document of the study and the full original reports of all 131 drugs evaluated. I just completed my outpatient for the day and will complete the documents tonight. It will be up on the meshindia.org website latest by Thursday night. The manuscript to be sent for peer review was completed a day before (I spend most of the weekend writing it) and is now circulated among my co-authors for suggestions, revisions and modifications. We will submit the paper (to an open access journal) for peer-review the coming week. Once again, our study is an independent quality assessment for the end consumer, not a regulatory body granting market authorization. When a generic drug passes these stringent dissolution and assay tests, it objectively demonstrates that it is not 'inferior' in its physical and chemical properties. Denying this data hurts patients by perpetuating an unfounded fear of affordable medicines that have been proven to meet quality standards. Yes, generics fail quality. Sometimes brands also do. But these must be considered rare events and not the routine. This is what the study showed. The study was cross-sectional and it never claimed everyone need to opt for generics now. It just showed that for people who cannot afford expensive brands, there are choices for them to continue their deserving treatments. Cross-sectional studies have their limitations, but for now, this is the best evidence we have against all the negative testimonials and second-hand anecdotes.

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PriyankaPulla
PriyankaPulla@PriyankaPulla·
@vishuguttal Lol, I would recommend reading the NYorker article fully though, if you haven't already.
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
Wtf is a "privacy fusspot"?
Amit Schandillia@Schandillia

I am usually not a privacy fusspot. Wanna show me ads? Go ahead. Wanna hear my conversations and gaslight my feed? Sure. Wanna track my movements? Meh. Just give me the convenience. That’s the reason I always found Apple’s privacy excuse for Siri sloppiness a tad unacceptable. I don’t mind a corporate “snooping into my life” if it makes life easier for me. I don’t mind the government playing the Orwellian “Big Brother” if it makes my country safer to live in. But to have on my device an unremovable spyware managed by the same government that not too long ago said Aadhaar was impossible to leak because the data was stored behind “12-foot walls”? That’s the exact opposite of security. No, I don’t mistrust the government. I mistrust its understanding of security against unaccountable bad actors. I don’t think am being unreasonable here. Sure, nothing will happen so long as my data is with the government. But what happens once it ends up on the other side of that “12-foot wall”? I say “once” and not “if” because…c’mon do I really have to spell that out? Of course am no rebel or anarchist, so not gonna give up using my phone if it really comes to pass. Am a law-abiding nobody, well-habituated to an arrogantly unscientific establishment with zero meaningful challengers. So life will go on. But I just wanted to register that I don’t like it. That shoving this Sarathi shit into our devices is not nice. That such moves may not inspire panic, but they do NOT inspire confidence either.

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PriyankaPulla
PriyankaPulla@PriyankaPulla·
Need some understanding about documentation of cases in Delhi HC. Would anyone among my followers know/be able to help?
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
For a story, The Bureau of Investigative Journalism is seeking patient experiences with substandard medicines (medicines that aren't effective or contaminated). If you or someone you know has had such experiences, fill the form here: docs.google.com/forms/d/e/1FAI… Share widely.
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
@roadscholarz Yes, sorry, my account is set to private, and that's why you can't retweet. Do you think you could copy and paste the tweet? Please feel free to tag me. Thank you.
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
For a story, The Bureau of Investigative Journalism is seeking patient experiences with substandard medicines (medicines that aren't effective or contaminated). If you or someone you know has had such experiences, fill the form here: docs.google.com/forms/d/e/1FAI… Share widely.
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
Really really unclear about where she is drawing this very fine line between "as dangerous as expected" and "not as dangerous as expected"
PriyankaPulla tweet media
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
Nice. The DPDP Act that the Karnataka caste-census consent-form cites is not in force; nor is the form's claim that it complies with the DPDP rules correct, because these rules haven't been notified yet :-/ medianama.com/2025/10/223-ka…
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PriyankaPulla
PriyankaPulla@PriyankaPulla·
For god's sake, don't set up another expert committee or CBI probe. Just go back and read the extensive literature already out there on why such contaminations happen. There is no big mystery here! livelaw.in/top-stories/co…
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