Simon J. Clark

I'll be chairing a session at this years ISER meeting in Valencia on 'The role of opsonisation and phagocytosis in ocular immune homeostasis' 23rd to 27th August in Valencia Spain! buff.ly/hGELKaF #Ophthalmology #ISER #retina #AMD #phagocytosis #microglia #macrophage

Welcome to Katia Ihadadene, who starts her PhD journey through the #Limits2Vision programme, studying the impact of damaged Bruch´s membrane on RPE metabolism, and how underlying genetic risk may alter this response. #VisionScience #Neuroscience #Collaboration #PhDJourney

New: THN391 — a single antibody that blocks neuroinflammation in Alzheimer's, MS & macular degeneration, without disrupting blood clotting. First-in-class. 🧠👁️ #Neuroscience #Biotech #AlzheimersResearch buff.ly/kvn5Com

Aging ECM alone can drive AMD-like pathology—new human Bruch’s membrane model reveals complement activation & lipid buildup. #Aging #AMD #Ophthalmology #ECM #Complement #DrugDiscovery buff.ly/LtiPTkj

Study finds AR visual noise may improve sight in AMD, pointing to a novel non-invasive digital therapy for vision loss. #DigitalHealth #MedTech #AMD buff.ly/a3gbxQ5

🚀 Ray Therapeutics raises $125M for genetic eye therapies targeting blindness. Strong signal for gene therapy and bold biotech innovation. 👁️✨ #Biotech #GeneTherapy #VisionRestoration buff.ly/BpoemQ4

Complement Factor H as a Novel Predictive Biomarker for Deep Vein Thrombosis Recurrence: A Prospective Cohort Study buff.ly/t6uUByX

Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular Degeneration buff.ly/GwUDS23

Human retinal organoid model of disease-relevant photoreceptor cell death amenable to drug screening buff.ly/YVGEGls

While one may 'fail' to achieve a primary outcome, the generation of data is never a failure. We can all learn and improve from data reported in these trials. FDA urges clinical trials report results buff.ly/hdvFE4y #clinicaltrials #clinicaltrials.gov #FDA #BioTech

Previously overlooked: a novel, potent factor B inhibitor scaffold enters phase 3 for PNH, emerging as a potential rival to Iptacopan and advancing complement-targeted therapeutics. #DrugDiscovery #Complement #PNH #Pharma buff.ly/P8kMHvI

New study reveals FHR-1 as both a driver of complement-mediated injury in IgAN and a novel therapeutic target, reshaping disease biology and treatment strategies. #IgAN #Nephrology #ComplementSystem #Immunology #MedTwitter buff.ly/giVErnc

Metabolomics + genetics reveal a powerful new way to predict AMD risk at population scale—linking systemic biology to eye disease. #AMD #Metabolomics #Genomics #AI #PrecisionMedicine #MedTech #PublicHealth buff.ly/RIz7oqv

AI-driven retinal imaging reveals intraretinal fluid as a key early biomarker predicting vision gains in nAMD—advancing precision treatment. #AI #Ophthalmology #AMD #MedTech #DigitalHealth #PrecisionMedicine buff.ly/Eo5z20y

New study reveals complement regulators—not just activation—shape GA progression in AMD, enabling functional patient stratification and precision care. #AMD #Ophthalmology #Immunology #PrecisionMedicine #Biomarkers buff.ly/JQ7bdR5

New research links a distinct AMD subtype (SDDs) to cardiovascular genetics, highlighting the retina as a window into systemic disease. #Ophthalmology #Cardiology #Genomics #PrecisionMedicine #AMD buff.ly/xweaJz7

I tell you what - it had better be worth it…..

Study of 156 dengue patients shows distinct complement signatures by disease severity, with soluble CR1 emerging as an independent early predictor of severe outcomes. #Dengue #Immunology #ComplementSystem #Biomarkers #GlobalHealth #Science buff.ly/da4fIQb

New study links gut microbiome function, not composition, to complement dysregulation and genetic risk in geographic atrophy, highlighting a systemic gut/immune/retina axis. #GeographicAtrophy #AMD #Microbiome #Genomics #Ophthalmology #Science buff.ly/7yU87jB

This is fantastic news from Complement Therapeutics! MHRA CTA approval for CTx001, which will lead to an expansion of the clinical trials into both the US and UK. #FDA #MHRA #clinicaltrials #AMD #IND #compelment #ophthalmology buff.ly/Fx8SF4O