Human Protein Atlas

At a recent high-level international meeting in Mexico City, 600 international delegated discussed trends in education, health and research. Mathias Uhlén shared a practical perspective on what universities must do as innovation cycles accelerate. proteinatlas.org/news/2026-03-1…

In a study in J.Proteome Res >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex IHC. The high-resolution data aids in further functional mapping of proteins with limited evidence. proteinatlas.org/news/2026-03-1…

A study in Science demonstrate that STING acts as a molecular barrier to bird flu and that a single substitution in the viral M1 protein leads to human IAVs evading activation of human STING, demonstrating the significance of this antiviral barrier. proteinatlas.org/news/2026-03-0…

February is the gallbladder and bile duct cancer awareness month, and also features the international World Cancer Day. This year's theme was "United by Unique" to raise awareness of the disease and request a cancer care more focusing on individuals. proteinatlas.org/news/2026-02-2…

In a report published in the Journal of Proteome Research last years advances and efforts within the HUPO coordinated Human Proteome Project (HPP) to define the human proteome and make proteomics an integral part of functional multiomics are presented. proteinatlas.org/news/2026-02-2…

The spatial expression pattern of TMEM213 in ductal structures of the salivary gland, based on mIHC/IF, show localization (green) to the apical part of the membrane of large ducts (red) but not to small ducts (magenta) or serous acini (cyan). proteinatlas.org/news/2026-02-0…

The HPA primary cilia study by Hansen published in Cell was recognized as setting a new standard for understanding ciliary function and its role in health and disease in a research highlight published in Nature Signal Transduction and Targeted Therapy. proteinatlas.org/news/2026-02-0…

Detection of cancer is challenging, especially since many common diffuse symptoms overlap with non-malignant conditions. In an article in Nat. Commun. plasma protein signatures were used to identify cancer among patients with non-specific symptoms. proteinatlas.org/news/2026-01-2…

Lysosomes play a central role in the controlled degradation crucial for cellular function and homeostasis. But what if the lysosomes themselves become damaged or dysfunctional? Recently a set of key players in the process called lysophagy was identified. proteinatlas.org/news/2026-01-2…

Ciliated cells are found in the endocervical epithelium in the inner canal of the cervix. Here the CAPSL gene is shown to be localized (green) to all of the annotated subcellular structures of the cervix ciliated cells except for the cilia basal body. proteinatlas.org/news/2026-01-1…

Insulin (green) is explored in endocrine pancreas using mIHC/IF and five peptide hormone markers specifically secreted by specialized endocrine cell types, including alpha cells (cyan) and delta cells (yellow) within the islets of Langerhans. proteinatlas.org/news/2025-12-3…

In PNAS researchers have used a combinatorial protein library that allow for selection of calcium dependency to select binders against the cancer receptor EGFR , an approach that generates fine-tuned binders and possibly enable new treatment regimes. proteinatlas.org/news/2025-12-1…

This year's Nobel Prize in Physiology and Medicine was awarded discoveries concerning peripheral immune tolerance and regulatory T cells. These immune cells play an important role in protection from autoimmune diseases and FOXP3 is key to their function. proteinatlas.org/news/2025-12-1…

In an article in Genetic Engineering and Biotechnology News, Gustav Ceder shares his impressions from the HUPO world congress in Toronto and the thoughts and perspectives from some of the big players in the proteomics field. proteinatlas.org/news/2025-12-0…

At the HUPO meeting in Toronto HPA members contributed more than 25 talks and posters. Loren Méar was selected as a poster competition finalist for her work "Spatial proteomics uncovers structural and molecular complexity of the human ovary in 2D and 3D." proteinatlas.org/news/2025-11-2…

Specific expression of the largely uncharacterized protein TMEM52B (green) in the apical part of the cytoplasm of distal tubular cells (red) highlighted with multiplex immunohistochemistry. Other visualized structures include the proximal tubules (white). proteinatlas.org/news/2025-11-1…

Version 25 of the Human Protein Atlas is launched. New additions are Olink HT and SomaScan data for 32 cohorts including diseases and childhood development, more single cell data with 4 new tissues and 23000 predicted structures for protein interactions proteinatlas.org/news/2025-11-1…

It is Movember and prostate cancer is in the spotlight. Explore prognostic genes associated with survival based on transcriptomics data and find out more about prostate cancer gene expression and cell line models in the Human Protein Atlas Cancer resource. proteinatlas.org/news/2025-11-0…

An article in PNAS investigates factors influencing recombinant protein expression in CHO cells showing that transgene mRNA abundance is not important, while MW, disulfide bonds, cysteine composition and N-linked glycosylation have the strongest effect. proteinatlas.org/news/2025-10-3…

Join our project “Embedding Multimodal Data in a Vector Database to Build a Blood Atlas” remotely for the BioHackathon Europé 2025! Join the project kick-off meeting October 28 at 16:00 CET. Passcode: B8GwzS us05web.zoom.us/j/4205147624?p…