ten Dijke Lab

Welcome to the official twitter account of the Peter ten Dijke lab at the Leiden University Medical Center, The Netherlands. Stay tuned for the latest updates from our lab! 👩‍🔬👨‍🔬

📢Vacancy alert: Research technician position available!

📢 New study from our group! Li et al. reveal how TGF-β regulates EV release and cargo in breast cancer by downregulating RAB27B. These EVs inhibit CD8+ T-cell cancer killing, highlighting potential targets to boost immunotherapy. Read more: doi.org/10.1002/jev2.7… #Cancer #EVs

Ten Dijke Laboratory on Chemical Signaling at LUMC, Netherlands, is hiring a technician with cellular signaling and protein chemistry background! The project focuses on characterizing novel degraders based on the PROTAC (Proteolysis Targeting Chimera) concept.

Aspiring PhD students, send in applications to join our team to research extracellular vesicles as cancer biomarkers

Our commentary on #GREMLIN1 acting as a #tumor promotor and suppressor is out! w/Brazil lab in Belfast and Julia Houthuijzen, @NKI_nl. There is more to the GREM1 story than the rules “no water, no sunlight after midnight” to stop Gizmo turning into Stripe. tinyurl.com/c6sfs235

Wonderful team effort w/Hinck/@MaizelsLab: helminth parasite secreting the #TGF-β mimic delivers immune-specific responses by binding to CD44. This may allow for therapeutic strategies e.g. inhibit human TGF-β signaling in a cell-type specific manner. shorturl.at/lmrJ7

📄Interested in the challenges and opportunities of lipid-based #nanoparticles as drug delivery system to improve #cancer immunotherapy? see our recent review (397 references!). We used lipid-based NPs delivery of STING agonists as example. onlinelibrary.wiley.com/doi/10.1002/mc…

[In Dutch] Highlights van de themabijeenkomst 'Vroege opsporing en monitoring van kanker'. Onderzoekers gingen met (ex) patiënten en andere geïnteresseerden in gesprek over hoe hun onderzoek bijdraagt aan de vroegtijdige opsporing & monitoring van kanker. oncode.nl/news/samen-van…

📄Why are #MesenchymalCancerCells less effectively killed by #cytotoxicTCells than #EpithelialCancerCells? Using #CRISPR screens, we identified properties of pancreatic #MesenchymalCancerCells that allow them to evade CD8+ T-cell killing. Yuan Gu et al. doi.org/10.1126/sciadv…

Studying cells and a zebrafish model, the @PtenDijkeLab discovers that the #lncRNA LETS1 promotes the migration of cancer cells through a positive feedback loop that drives #TGFbeta signaling and #EpithelialToMesenchymalTransition. @LUMC_Leiden scim.ag/35p

📃Are you interested in how an unannotated long non-coding #RNA, termed #LETS1, can enforce TGF-beta signaling in migration and #EMT in breast and lung #cancer? Check out our recent paper in Science Signaling from Chuannan Fan et al. @LUMC_Leiden science.org/doi/10.1126/sc…

@kwf_nl has granted our grant application! 🎊A great collaboration with @LUMC_Leiden Department of Surgery: Alexander Vahrmeijer, Martijn van Dam, Sven Mieog and Bert Bonsing, Department of Cell and Chemical Biology: @AgustinEncisoM and @dijke_ten, and Surgimab.

Great presentations from Jeroen de Ridder, @AgustinEncisoM and Leon Terstappen. Lively discussions with cancer patients and patient organizations. Many thanks to @oncodeinstitute, Marline Smit and Mariëlle Harlé for great support (Photography by Marloes van Laloes). [2/2]

On Saturday 13 May, Colette ten Hove and @dijke_ten from @oncodeinstitute organized a Patient Engagement Program event on "Early detection and monitoring of cancer" in beautiful Leiden, Rijksmuseum Boerhaave. [1/2]

📃Our paper is out on how activation of #TGF-beta receptor signaling promotes #melanoma metastatic outgrowth in liver: lnkd.in/ertgPDm9

Op zaterdag 13 mei organiseert @oncodeinstitute en @dijke_ten een themabijeenkomst “Vroege opsporing en monitoring van #kanker” voor #kankerpatiënten en hun naasten, leden van #kankerpatiëntenorganisaties en #onderzoekers. Ga naar oncode.nl/events om je in te schrijven.

🚨Post-doc opening!🚨 Are you passionate to develop novel #microfluidics to capture #CTCs? We are seeking a highly motivated Post-doc researcher with an interest in cross-disciplinary research to join our collaborative project with @PtenDijkeLab. RT🙏 lnkd.in/e3dY--tT

📄Paper on combining oxaliplatin-loaded #liposomes with STING agonist to reduce #tumor growth is out! Gu et al. J Control Release. #Cancer #Immunochemotherapy #Nanomedicine pubmed.ncbi.nlm.nih.gov/37030544/

📄@LUMC_Leiden researchers have discovered a Long non coding RNA that acts a gatekeeper for epithelial state of normal and #cancer cells and that inhibits #TGF-beta-induced EMT of breast and lung cancer cells. embopress.org/doi/full/10.15… Video synopsis: youtu.be/IDD7rhGchfk

NOW ONLINE The @PtenDijkeLab found that low expression levels of optineurin in triple-negative #BreastCancer are correlated with higher metastasis incidence, making it a potential prognostic indicator to stratify patients 🔓OPEN ACCESS ➡️doi.org/10.1002/ijc.34…