Roberto Toro [email protected] r3rt0.bsky.social

Interested in the development of brain folding? We have 2 postdoc positions to study the molecular and mechanical causes of brain folding! Thread 1: Modelling different hypotheses of brain folding Thread 2: Multimodal, multi-scale atlas @BorrellLab @neuroliege @Franze_Lab (1/3)

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @R3RT0 , doi.org/10.1101/2025.0…

@BenjaminLy61243 @katjaQheuer @LFeldmanBarrett thank you! 🙏

@R3RT0 @katjaQheuer @LFeldmanBarrett Bernstein's classic "The co-ordination and regulation of movements" is the cite, but it's honestly dense and kind of hard to read, I prefer the Esther Thelen stuff, check out this great summary paper: pubmed.ncbi.nlm.nih.gov/7879990/

@caglarag_lar @katjaQheuer should be the case! check the 'epithelial mechanics' group of people in bsky for many examples <3

@katjaQheuer @R3RT0 This holds for cellular morphology?

@BenjaminLy61243 @katjaQheuer @LFeldmanBarrett The idea has deep roots! We have a chapter on the Evolution of cortical folding ready to go. We talk a bit about the Developmental Mechanics of Wilhelm His back in ~1844. I'll have to check Bernstein. Any reference in particular? (I started following you on bsky 😋)

@katjaQheuer @LFeldmanBarrett The role of internal mechanical forces in determining the development of a motor behavior in addition to the roles of nature and nurture goes back at least to Nikolai Bernstein, probably some very interesting connections to explore here....

@nicolas_traut @NeuroecologyLab @BorrellLab @R3RT0 19 Extra bonus: Flight through the whole brain connectomes of the 4 large brained species capuchin, colobus, macaque and mangabey.

12 All this suggests that mechanical morphogenesis may be a major 3rd causal determinant of the development and evolution of brain organisation in primates.

6 Zoom into illustration #2: New World monkeys like capuchins have much more folded brains than their Marmoset cousins. Surprisingly, their folding pattern is almost identical to that of Old World monkeys like macaques despite ~47my independent evolution—as much as whales&hippos!

5 Lining up primate brains solely based on their size provides a 1st striking illustration of the importance of mechanical morphogenesis: despite jumping across far branches of the phylogenetic tree, the sequence is continuous, hinting at a common underlying organising principle.

Lifestyle is a stronger predictor of aging and mortality than genetics. A new Nature study of ~500,000 people found: 🎯 17% of mortality variation was linked to lifestyle (exposome). 🧬 <2% of was explained by genetics. Here’s what you need to know 👇🧵 1/10

@ECaruyer @JakobWasserthal Thank you @ECaruyer for the shoutout :D We still use brainbox.pasteur.fr for all our manual segmentation needs. For example, the segmentations for @katjaQheuer's paper on the cortical folding of 34 primate species were all done using BrainBox! doi.org/10.1016/j.cort…

@JakobWasserthal This is very cool, this remains me of brainbox.pasteur.fr, that @R3RT0 presented a few years ago when visiting us!

Introducing TotalSegmentator Annotate: a simple web-based tool where anyone can help improve segmentation data. Your contributions directly help us train a better, smarter TotalSegmentator. Start making an impact today. (Link in the comments)

Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch Read this #OpenAccess Research Article by Tim Yeung @tim_justina and David Wilkinson @TheCrick: doi.org/10.1242/dev.20…

Svante Paäbo has been made Honoris Causa doctor of the University of Liège. Followed by a geeat meeting with him at GIGA on this occasion @GIGA_ULiege @UniversiteLiege @frsFNRS

ping @R3RT0 Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology | bioRxiv biorxiv.org/content/10.110…

🦠 For the next FRESK seminar on monday, December 9th, we meet Suchismita Das (LPENS) for the next presentation: "Active colloidal matter: flocking and wetting transitions" qbio.ens.psl.eu/en/events/inte…

@CandiceCheung12 @institutpasteur We don't have a set deadline. If we find someone, the starting date could be right now!

@R3RT0 @institutpasteur When is the application deadline?

🚨 We’re hiring! 🚨 We're looking for a postdoc for our ERC Synergy project Unfold (unfold-lab.github.io). Join our lab at @institutpasteur to model brain morphogenesis! (1/10)

Ce vendredi midi, la Caisse des Écoles de Paris Centre adopte le Croc de #notrecafemarais. 🙏à tous ceux qui ont participé à cette initiative et 👏à notre belle équipe Steeve, Nadine et Anastasia en cuisine à l’école de la place des Vosges. #accessibiliteuniverselle

@w40nsk1 @PslQlife @QBio_PSL @AlainGoriely @BrunoLevy01 @katjaQheuer @EpiMechFC Please do Bruno! Thank you very much🙏!

@R3RT0 @PslQlife @QBio_PSL @AlainGoriely @BrunoLevy01 @katjaQheuer @EpiMechFC I know a couple of recently minted PhD who should be a good fit (dsspite coming from very disparare areas), and might be interested. I'll pass it forward.

Thread 2: Multimodal atlas of brain development (3/3) x.com/R3RT0/status/1…

Thread 1: Modelling brain development (2/3) x.com/R3RT0/status/1…

Interested in the development of brain folding? We have 2 postdoc positions to study the molecular and mechanical causes of brain folding! Thread 1: Modelling different hypotheses of brain folding Thread 2: Multimodal, multi-scale atlas @BorrellLab @neuroliege @Franze_Lab (1/3)

Please repost 🙏 ! @BorrellLab @neuroliege @Franze_Lab @AmyFDHoward @SaadJbabdi @BrunoLevy01 @piloubazin @MichelTdS

📜 Profile: Neuroscientist with a quantitative background (eng/comp sci/maths), with experience working with pixels, voxels and meshes, computational neuroanatomy, programming skills (Python, Javascript) and passion for brain development 🔗 DM for info! Spread the word! (10/10)

🧠 Come work with us! Our lab at @institutpasteur looks for a postdoc to help us create the most complete open atlas of brain folding development! This is part of our ERC Synergy project Unfold (unfold-lab.github.io). Join us! (1/10)