Karousis Lab

Time to switch... KarousisLab in 🦋

Our latest work is out in @Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…

New pre-print 📢:Cell-free translation from diverse human cell types: Fast, reproducible and scalable @JZiegelmuller @OMuhlemann @MCIDBern @DCBPunibern @unibern biorxiv.org/content/10.110…

@lapassmore Great work with very exciting insights, congratulations!

Preprint here: biorxiv.org/cgi/content/sh…

New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB @ERC_Research

@LabFaso @unibern @DCBPunibern @NCCR_RNADisease @MCIDBern Thanks a lot, Carmen! 😄

#Habilitation done! 🎉 I’m grateful and proud to receive the Privat Dozent title from @unibern, an institution with a special place in my heart. I'll strive to stand as an ambassador of its values in sharing my passion for Biochemistry and Molecular Biology. @DCBPunibern

@Jonathan_Bohlen Thanks Jonathan! 😄

@RNAkook @unibern @DCBPunibern @NCCR_RNADisease @MCIDBern Congrats Evan! You're a scholar and one of great caliber !

@nicolamlow Sometimes, it's almost impossible to find a snack that won't ruin your nutritional goals!

More than 75% of popular takeaway and restaurant food is unhealthy, study finds #CommercialDeterminantsOfHealth theguardian.com/food/article/2…

6/ We conclude by addressing the (co)-evolutionary interplay between Nsp1 and the 5'UTR from different Betacoronaviruses🦠

5/ We evaluated Nsp1 previously proposed Nsp1 inhibitors, Montelukast and Mitoxantrone, finding them ineffective against Nsp1’s ability to inhibit translation. 🚫

1/ Preprint alert📢: Uncoupling the functional roles of Coronavirus Nsp1 biorxiv.org/cgi/content/sh… #biorxiv_molbio Doubly excited because this work is based on our first Master's student to graduate from the lab, Emilie Bäumlin. @unibern @DCBPunibern @MCIDBern @NCCR_RNADisease

Thrilled to see @Jonathan_Bohlen, starting his group, very, very well deserved!

Please RT: Are you a highly skilled, top-motivated biochemist looking for an exciting postdoc project? We are looking for you. For details, check here: ohws.prospective.ch/public/v1/jobs…

Is Science Direct down for everyone? Any ideas how to circumvent it when doing doi-based paper searches? #sciencedirect #AcademicTwitter #AcademicChatter

Today we report in @natBME the eePASSIGE system, which uses evolved and engineered recombinases and prime editing to integrate large gene-sized DNA cargoes into the mammalian genome in an efficient, precise, and targeted manner. (1/13) drive.google.com/file/d/1WDMVqL…

We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/…