Reproduction and Fertility

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Explore the Special Collection: raf.bioscientifica.com/page/IRaIMiRHa… #Pregnancyloss #IVF #Miscarriage #immuneresponse #inflammatoryresponse

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Day 5 - Our #RaFJC comes to its end. We toured the reproduction path as an immune continuum. From ovulation, implantation, pregnancy outcomes, and therapies. #Pregnancyloss #IVF #Miscarriage #immuneresponse #inflammatoryresponse

Read the full article here: doi.org/10.1530/RAF-25… Explore the special collection: raf.bioscientifica.com/page/IRaIMiRHa… #RaFJC #Pregnancyloss #IVF #Miscarriage #immuneresponse #inflammatoryresponse

New concept: placenta‑targeted nanoparticles for localized immune cloaking. Cost‑optimized, safer than systemic immunosuppression.

#RaFJC Day 4 - RPL = ≥2 miscarriages, affecting 1–2% of couples. Half remain unexplained, often immune‑related. #RaFJC #Pregnancyloss #IVF #Miscarriage #immuneresponse #inflammatoryresponse

Immune profiling in patients with positive hCG could become an early diagnostic tool. 👉 Read the full article: doi.org/10.1530/RAF-24… Explore the special collection: raf.bioscientifica.com/page/IRaIMiRHa…

B cells rise in all pregnancies, but only pNK signatures distinguish viable vs non‑viable outcomes

#RaFJC Day 3💚 Pregnancy is an immune balancing act: tolerance of the fetus + defense against pathogens.

Are you interested in this topic? Explore our next Special Collection : Immune Regulation and Inflammatory Mechanisms in Reproductive Health and Disease, and submit your article to be a part of it! raf.bioscientifica.com/page/IRaIMiRHa…

Implantation depends on a fine balance of the immune system. When tolerance and inflammation fall out of sync, the risks rise — from failed implantation to recurrent miscarriage and pregnancy complications. #RaFJC #Implantation #Fertility #immuneresponse #inflammatoryresponse

𝗗𝗮𝘆 𝟮 𝗼𝗳 #RaFJC 💚 Implantation requires delicate immune balance. Enough inflammation to remodel the uterus, but enough tolerance to accept the embryo. Cytokines, NK cells, and macrophages shape embryo acceptance. #RaFJC #Implantation #Fertility #immuneresponse

Immune + extracellular membrane pathways emerge as key players! Read the full article here: doi.org/10.1530/RAF-22… #RaFJC #Ovulation #POI #Fertility

🐁A mouse model shows cathepsin K triggers rapid ovarian transcript changes

👱‍♀️POI affects 1–3% of women <40; most cases are unexplained.

We’re excited to announce our next Journal Club! Hosted on all RAF social platforms, this week-long event will feature discussions on 3 articles, covering the journey from ovulation to conception & implantation, through pregnancy & delivery, & clinical translation. #RaFJC

New research by Meron Asmamaw Alemayehu et al. finds machine learning models can help identify factors linked to delayed fecundability among women in sub-Saharan Africa - paving the way for more targeted fertility support. 🔗Read the full article here: doi.org/10.1530/RAF-25…

Did you know Reproduction & Fertility is co-owned by both the Society for Endocrinology & the Society for Reproduction & Fertility? Members of either society get 25% off APCs when publishing with us! For more info visit: raf.bioscientifica.com/page/about-RAF…