FOS Research

NUS researchers developed AI methods that learn large-scale behaviour of complex materials from microscopic data. By identifying hidden variables capturing collective behaviour, they predict how materials evolve over time, reducing costly simulations. journals.aps.org/prmaterials/ab…

Phenalenyl-Fused Nickel(II) Norcorroles with Precisely Oxygen-Edited Skeletons: Tuning Aromaticity and Site-Selective Reactivity @NanoLetters. Many thanks to our wonderful collaborators, Prof Xian-Sheng Ke @BNU_1902, Yuanyuan He, @borylation @jishan_wu etc pubs.acs.org/doi/10.1021/ac…

🔬Microplastics are showing up in coral reef sediment & water across Singapore's urban reefs (🧴🎣). Our study shows abundance is associated with fine sediments & low water energy, not coral cover or reef rugosity — sheltered reefs may be most at risk! 🪸 doi.org/10.1016/j.marp…

NUS food scientists have used machine learning to sift through over 2,300 scent molecules from aromatic plants and identify compounds with sleep-promoting potential, an approach that could accelerate the discovery of natural sleep aids. pubs.rsc.org/dd/article/5/3…

NUS researchers have developed a computation-guided strategy to produce urea more efficiently from carbon dioxide and nitrate. They identified a catalyst that maintains high urea selectivity at practical current densities. nature.com/articles/s4416…

NUS researchers have developed an AI-guided workflow that combines AI with molecular simulations to identify potential drug candidates for diabetic wound healing, identifying folic acid, a common vitamin, as a top candidate. pubs.acs.org/doi/10.1021/ac…

NUS researchers have discovered that cancer cells do not simply push through surrounding tissues to spread, but instead actively grip onto protective tissue barriers and pull them apart, revealing a fundamentally new mechanism of cancer invasion. cell.com/developmental-…

NUS researchers have developed a predictive strategy for graphene-like molecules with multiple interacting spins and resilience to magnetic perturbations, opening avenues for molecular-scale quantum information technologies and next-generation spintronics. nature.com/articles/s4416…

NUS mathematicians and their collaborators have established a precise form of a conjectural duality, known as Relative Langlands duality, for an important class of mathematical spaces. link.springer.com/article/10.100…

NUS researchers have built a molecular “leash” to pull directly on a force-sensing protein called Piezo1, and discovered it switches on at about 15 piconewtons, proving that it can be activated by physical tethers, not only by membrane deformation. nature.com/articles/s4446…

NUS scientists have collaborated with the Health Science Authority on the investigation of biomarkers of synthetic cannabinoids. youtube.com/watch?v=GNrXix…

NUS researchers have developed a boron-catalysed method to transform oxetanes into larger, medicinally relevant 1,3-oxazinanes by the selective insertion of two building blocks, a carbon unit and a nitrogen unit. nature.com/articles/s4416…

NUS scientists have developed a biochemical technique that captures fleeting “handshakes” between newly made proteins and the cellular helpers. These interactions can determine whether a protein turns out healthy and useful. cell.com/molecular-cell…

NUS biologists have uncovered how the protein NuSAP safeguards tiny structures inside cells called centrioles, revealing a mechanism linked to developmental disorders such as microcephaly and mosaic variegated aneuploidy (MVA) syndrome. advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

NUS researchers have identified a protein called tyrosine phosphatase 1B (PTP1B) as a potential “switch” that can modulate a type of cancer cell death known as immunogenic cell death. pubs.acs.org/doi/10.1021/ja…

NUS Researchers have developed CellScope, a high-performance single-cell analysis framework that uses manifold fitting to analyse single-cell RNA sequencing (scRNA-seq) data. nature.com/articles/s4146…

NUS researchers have developed a “capping-and-coupling” strategy to transform naturally occurring (native) sugars directly into compounds known as C-heteroaryl glycosides. nature.com/articles/s4416…

NUS scientists have discovered that atomic-scale substitutional dopants in ultra-thin 2D materials can act as stable quantum systems operating at terahertz frequencies. pubs.acs.org/doi/abs/10.102…

NUS chemists have developed a single-atom photocatalytic strategy that enables oxidant-free cross-dehydrogenative coupling reactions between ring-shaped aromatic molecules ((hetero)arenes) and nucleophiles. nature.com/articles/s4192…

NUS researchers have developed an electrochemical reaction manifold that promotes efficient nitrogen atom insertion into saturated carbocycles to access either functionalised quinolines or N-alkylated saturated N heterocycles. nature.com/articles/s4416…