FOS Research

NUS researchers have built a molecular “leash” to pull directly on a force-sensing protein called Piezo1, and discovered it switches on at about 15 piconewtons, proving that it can be activated by physical tethers, not only by membrane deformation. nature.com/articles/s4446…

NUS scientists have collaborated with the Health Science Authority on the investigation of biomarkers of synthetic cannabinoids. youtube.com/watch?v=GNrXix…

NUS researchers have developed a boron-catalysed method to transform oxetanes into larger, medicinally relevant 1,3-oxazinanes by the selective insertion of two building blocks, a carbon unit and a nitrogen unit. nature.com/articles/s4416…

NUS scientists have developed a biochemical technique that captures fleeting “handshakes” between newly made proteins and the cellular helpers. These interactions can determine whether a protein turns out healthy and useful. cell.com/molecular-cell…

NUS biologists have uncovered how the protein NuSAP safeguards tiny structures inside cells called centrioles, revealing a mechanism linked to developmental disorders such as microcephaly and mosaic variegated aneuploidy (MVA) syndrome. advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

NUS researchers have identified a protein called tyrosine phosphatase 1B (PTP1B) as a potential “switch” that can modulate a type of cancer cell death known as immunogenic cell death. pubs.acs.org/doi/10.1021/ja…

NUS Researchers have developed CellScope, a high-performance single-cell analysis framework that uses manifold fitting to analyse single-cell RNA sequencing (scRNA-seq) data. nature.com/articles/s4146…

NUS researchers have developed a “capping-and-coupling” strategy to transform naturally occurring (native) sugars directly into compounds known as C-heteroaryl glycosides. nature.com/articles/s4416…

NUS scientists have discovered that atomic-scale substitutional dopants in ultra-thin 2D materials can act as stable quantum systems operating at terahertz frequencies. pubs.acs.org/doi/abs/10.102…

NUS chemists have developed a single-atom photocatalytic strategy that enables oxidant-free cross-dehydrogenative coupling reactions between ring-shaped aromatic molecules ((hetero)arenes) and nucleophiles. nature.com/articles/s4192…

NUS researchers have developed an electrochemical reaction manifold that promotes efficient nitrogen atom insertion into saturated carbocycles to access either functionalised quinolines or N-alkylated saturated N heterocycles. nature.com/articles/s4416…

🆕📢 We are excited to present the first multi-matrix study of MP in Singapore’s coral reefs. Our low detected levels show that urban reefs aren’t always MP hotspots! 🪸✨ authors.elsevier.com/a/1m18r15DSlZM… (50-day free access)

NUS chemists have developed a methodology to enable coupling reactions for the growth of crystalline porous covalent organic frameworks, unlocking a new class of semiconducting magnets. nature.com/articles/s4416…

NUS scientists have developed a more heat-resistant material that keeps next-generation solar cells running more efficiently to enable durable, high-output solar panels. science.org/doi/10.1126/sc…

NUS researchers and partner universities in China have achieved highly efficient electroluminescence from lanthanide nanocrystals, paving the way for durable, tunable light technologies nature.com/articles/s4158…

NUS researchers have developed LocusCompare2, an online platform that combines multiple methods for identifying causal genes to better understand the genes that are responsible for certain traits or diseases. nature.com/articles/s4158…

NUS researchers have fabricated ultra-thin memtransistor arrays from 2D TMDC with controllable Schottky barriers. These arrays are highly uniform, demonstrating low device-to-device variation and provide high performance for image recognition tasks. nature.com/articles/s4146…

NUS chemists have found a new use for DNA, not just as genetic material, but as a tool for more efficient production of medicinal compounds. nature.com/articles/s4192…

NUS scientists have discovered a simple DNA “switch” that helps tropical butterflies adjust the size of their wing eyespots in response to seasonal temperatures, shedding light on the evolution of environmental sensitivity. nature.com/articles/s4155…

Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @Nature that exchanges O within an oxetane for N, S, C & even dual atoms, simplifying access to a variety of non-aromatic cyclic pharmacophores & enabling late-stage editing of complex bioactive molecules. Great DFT insights from @XZhangChem. @ChemNUS @ResearchFoS @NUSResearch #skeletalediting #atomswap #photocatalysis #oxetanes #azetidines #thietanes #cyclobutanes #drugdiscovery nature.com/articles/s4158…