Francesco Ricci Lab

Immune-Induced Antibody–DNA Hybrid Condensates | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

All results were nicely described by theory and simulations of a phase-field model by our collaborators Lorenzo Rovigatti and Marco Cappa @SapienzaRoma. Finally thanks to co-corresp author @erica_delgrosso for her invaluable support and @AIRC_it and @ERC_Research for funding. 6/n

We also show that by simply replacing the antigen on the DNA nanostar we can induce the phase separation of different condensates in a orthogonal way without any crosstalk...here is the microscopy image of three condensates formed upon addition of three different antibodies! 5/n

New paper from our group just out in @J_A_C_S! We show the combined use of DNA-DNA and antibody–antigen interactions to induce phase separation of antibody–DNA hybrid condensates. pubs.acs.org/doi/10.1021/ja… Congrats to Sara (@sara29_ss) for her first first-author paper!👇🧵 1/n

All places have been filled!

The next Functional DNA Nanotechnology workshop #FDN2025 (Rome 15-17 October) is just around the corner! Due to last minute cancellations, we still have a couple of places available if anyone is interested... fdn2025.com

Nice to see this collaborative work out in @angew_chem. We joined forces with @Ale_Sorrenti1 and @PuigmartiLuis to achieve non-equilibrium steady states using DNA-based systems and controlled RNA fuel supply. Congrats to @erica_delgrosso and @JamesDNicholas🥳

Excited to see our latest work finally out in @NatureNano 😍😍. Great collaboration and many thanks to all the authors @leonard_prins @RicciLab @benjamino_acid and @Epenocchio 🥳🥳

Great to see this is now out in @NatureNano! Thanks to @leonard_prins for this (yet another) collaborative project...kudos to @erica_delgrosso and Ben Roberts for combining experiment and theory in such a nice way. Thanks also to @EPenocchio for help with the theoretical part!

Hurry up! Today is the deadline to submit an abstract for the next Functional DNA Nanotechnology workshop #FDN2025, Rome 15-17 October 2025! Co-organized with Tim Liedl (@CeNS_LMU) and Fritz Simmel. fdn2025.com

@rjerala Very nice! Coupling the programmability of nucleic acids with the versatility of proteins might indeed become a game changer for many applications...

Proteins are nucleic acids are programmable molecules that can assemble into amazing functional nanostructures. Why not merry them even more tightly by stable covalent bonds? doi.org/10.1002/smll.2… 👇

Finally, big congrats to our PhD student Francesca Miceli for her first first-author paper and to all the coauthors (@Simona_Ranallo, @BracagliaSara, @SorrentinoDa, @alessan_porch).

The name of the assay is an homage to one of the best examples of CRISPR-based sensors (SHERLOCK, @Sherlock_Bio) developed by @zhangf, Collins + colleagues. While SHERLOCK detects DNA/RNA strands, MAIGRET enables the detection of proteins, antibodies and other molecules. 5/n

The paper describing our MAIGRET (Molecular Assay based on antibody-Induced Guide-RNA Enzymatic Transcription) system is finally out in @NAR_Open! academic.oup.com/nar/article/53…. @ERC_Research, @AIRC_it 1/n