Fagan Lab at the University of Sheffield

🚨 Fully funded PhD studentships 🚨 We have 3 fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss

Project 3: Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile. findaphd.com/phds/project/b…

Project 2: Doubling down: determining the dual function of VanT in C. difficile antibiotic resistance. findaphd.com/phds/project/m…

More info on the MSCA schemes here: …sklodowska-curie-actions.ec.europa.eu/calls/msca-pos… and you can see a few of our current projects here: sites.google.com/sheffield.ac.u…

The Marie Skłodowska-Curie Actions Fellowships support applicants up to 8 years post-PhD from anywhere in the world who want to spend 1-2 years working in Europe (incl. UK!). These can be a fantastic stepping stone to longer term fellowships and establishing independence

The 2025 round of the MSCA Postdoc Fellowships launches soon, with a deadline of September 10th. If you're interested in Clostridial cell biology and looking for a host lab for your fellowship please get in touch to discuss possible projects

There is still a huge amount of work to do but this is a fascinating first look at an S-layer penetrating phage!

Interestingly the tail contracts less than in other characterised phages (& related contractile structures). This seems to be a feature of phage infecting bacteria that have an S-layer - given that these are likely the majority of bacteria, this is probably really common

New paper alert 🚨 We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance

@lizopawoye @ellieevolves Potentially yes - please see the details below x.com/RobFagan/statu…

@RobFagan @ellieevolves Hello Dr Fagan is this project still available?

We have 2 fully funded PhD studentships available through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on #phage that infect #Cdifficile

The 2nd round of our Yorkshire Biosciences PhD programme is now open for applications - deadline March 14th. Both of our C. diff phage projects are also available in this round - details in the thread below. More info and expressions of interest here: app.onlinesurveys.jisc.ac.uk/s/leeds/ybdtp-…

No2...Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile with @RobFagan tinyurl.com/22vzvb27 #microbialevolution #pathogenevolution #PhDposition

PhDs avaliable in the lab! No1....what are rhizobia up to OUTSIDE the symbiosis? tinyurl.com/8mybvaha with Prof Tim Daniell. Come along to our project info session Tues 10th at 2pm. register here tinyurl.com/y76au57n #microbialevolution #symbiosis #PhDposition

Project 2: Led by Per Bullough and in collaboration with @Sheffield_AFM we will study the structural basis of #phage infection of #Cdiff cells at unprecedented resolution. #cryoEM #AFM findaphd.com/phds/project/m…

Project 1: Led by @ellieevolves, we will study the evolutionary interplay between #Cdiff and #phage and impact of sporulation on this relationship. findaphd.com/phds/project/p…