Robert Signer

@WaxMetrix I had 6 Tier One boxes (haven’t opened any yet). Weighed them on a precise scale - 4 boxes very similar to each other, 1 substantially heavier, and 1 that is way lighter than average. What could account for the lighter box? Redemption? Packing error?

2026 Topps Tier One & 2025 Topps Dynasty MLB Just A Couple Quick Notes I don't think either one of these necessitates an entire breakdown, but I did want to show them a little attention. 2026 Tier One Basics: 4 cards per box consisting of 2 autos, 1 relic, & a base or parallel. Something like 10% of boxes should contain an extra hit. Currently $465/box at Big Bully resellers. Total cards in product: 255,076 2025 Tier One- 225,200 YOY +13.3% Total boxes: 63,769 Up from 56,300 in 2025 Hit Rates: 83% of boxes should contain a base parallel as the base card. In 47% of boxes the parallel should be numbered as there are unnumbered parallels (Bronze, possibly Holo Gold) 61% of boxes should contain a Relic Auto as one of the Autos Print Runs: Base Tier 1- ~95 ea Tier 1 Holo Gold- ~17 ea Base Tier 2- ~115 ea Tier 2 Bronze- ~215 ea Tier 2 Holo Gold- ~17 ea Tier 3 Bronze- ~355 ea Tier 3 Holo Gold- ~17 ea I'm not going to list any Auto or Relic print runs. I think they should all be numbered, but the numbering is all over the place. If you have any unnumbered ones, feel free to reach out and I'll tell you what I have for a print run. Verdict: There are some absolutely spectacular hits that will come from this- Bat Knobs, Booklets, nasty Patch Autos, Cut Signatures, Triple Autos, etc. Also, from a $465 box, there are a ton of names that will make you feel like you're on a Jackass skit. If you don't mind being bludgeoned just to take a chance at those sweet knobs, whatever you do, DO NOT buy these sealed from ebay. Many of the desirable hits are easily searchable by weight. 2025 Topps Dynasty MLB Basics: 1 ultra high-end card per box Pre-order price- $1500/box Current market- $3600/box Total cards in product: 16,045 2024 Dynasty- 9,470 YOY +69.4% Verdict: If you're buying this to rip, the metrics don't matter. Also, if you're buying this to rip, please hire me as an intern. I just want to learn from you. Every card is /10 or less. Every card is a patch auto. Obviously, every card is a Quality Hit. Some of the nastiest cards in the hobby come from Dynasty. The problem is, I suspect maybe 5-10% of pulls would actually pay for the box. One card for $3600 is absurd. If this were available at pre-order price of $1500, I can understand a YOLO. Buy singles. They're fantastic. #thehobby #SlabSquatchAnalytics #2026ToppsTierOne #2025ToppsDynasty

Why is it so difficult to grow hematopoietic stem cells in culture? Huge increases in protein synthesis disrupt proteostasis in HSCs ex vivo. HSF1 comes to the rescue ex vivo & during aging to keep stem cells fit. Our latest now in print @CellStemCell cell.com/cell-stem-cell… 🧵

FREE registration for the Sanford Stem Cell Symposium is now open. Join our incredible lineup of speakers discussing stem cells in regenerative medicine, cancer, aging, bioengineering, genomics 🧬 & space 🚀. Agenda: stemcells.ucsd.edu/sanford-stem-c… Registration: eventbrite.com/e/sanford-stem…

.@UCSDMedSchool researchers unlock a way to keep lab-grown stem cells healthy, which is positive news for people who need bone marrow transplants when donor stem cells are not available. The approach may also help further aging research. ow.ly/nSpg50FR4Vi

If you can’t take the heat, get out of the culture. Our latest paper in @CellStemCell uncovers how HSF1 keeps stem cells fit in a dish. 🔥💪 authors.elsevier.com/sd/article/S19…

DOUBLE THE @NIH BUDGET. Science is critical for our economy, health & security. Science is conquering #COVID and is essential for tackling future pandemics and other diseases. But science is woefully underfunded. NOW IS THE TIME.

While we’re focused on the BIG discoveries that enabled the rapid development of the #COVID vaccine, let’s not forget the engine that powered it: trainees, long days, failed experiments, rejection, persistence, resiliency. This is progress. This is science.

Why do some genetic disorders present in kids and others in adults? Our new paper w/@Magee_Lab reveals that BIG changes in protein synthesis during ontogeny sensitize distinct hematopoietic cell types to a ribosomal mutation in an age-dependent manner. cell.com/stem-cell-repo…

Attention hematopoiesis community: Have you ever been confused about which set of markers to use to identify HSCs and MPPs? We hope to bring clarity & unity to the field. Tune in to this important @ISEHSociety webinar on Tuesday, November 10th!

ERADicating stem cells from their niche. Our News & Views on exquisite new work from @XiChenLab in @NatureCellBio on how proteostasis regulation by the ERAD pathway influences the interaction of HSCs with their perivascular niche in the bone marrow. rdcu.be/b7vFR

Why do ribosomal mutations only impair certain cell types? Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis. New preprint w/@Magee_Lab. disq.us/t/3r7tu57

Humbled to be included with these outstanding scientists. Thank you @LLSusa, @TheMarkFdn & @AllenInstitute for supporting our innovative research targeting protein synthesis to treat blood #cancers.

The proteostasis network functions uniquely in hematopoietic stem cells to promote their life-long regenerative function. Learn more in our latest review in @CO_Hematology. journals.lww.com/co-hematology/…

My op-ed in @sdut explains why we all must stay home and practice responsible social distancing to safeguard our communities. #coronavirus #COVID19v@UCSDHealth @Kevin_Faulconer @CityofSanDiego @CAgovernor

My op-ed in @sdut explains why we all must stay home and practice responsible social distancing to safeguard our communities. sandiegouniontribune.com/opinion/commen… #coronavirus #COVID19 #UCSDHealth @Kevin_Faulconer @CityofSanDiego @CAgovernor

The @SignerLab is hiring Postdocs! Our curious and creative team @UCSDHealth investigates how the proteostasis network is uniquely configured to promote stem cell function and longevity, and encompasses new therapeutic targets in cancer. Info: signerlab.com. Please RT!

DNA isn’t destiny. Stem cell identity and function depend on the epitranscriptome, translational control and protein degradation to regulate proteome content, quality & complexity. New review on post-transcriptional control of stem cells in @CellStemCell. sciencedirect.com/science/articl…

Modest declines in proteome quality impair hematopoietic stem cell self-renewal bit.ly/2NopWoq

Misfolded proteins are associated with Alzheimer’s, Parkinson’s and other neurodegenerative diseases. New research reveals that misfolded proteins also impair stem cell function and tissue regeneration. cell.com/cell-reports/f… #stemcell #proteostasis #sparkjoy

The Science of Tidying Up: Stem cells depend on low protein synthesis to prevent the biogenesis of misfolded proteins. cell.com/cell-reports/f…