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2/ Evidence
1️⃣ Pfizer announced Phase 2/3 study results of EPIC-HR
2️⃣ Sig reduces Hosp & Death w COVID infxn if given w/in 3 or 5d of sx onset (2ndary endpoint)
3️⃣ World-wide participants. 41% US
4️⃣ Primary endpoint of sx alleviation not met
5️⃣ Sig reduces viral load @ day 5
Robin Snellings, MD@RobinSnellings
1/ What's PAXLOVID? 💊 1️⃣ Nirmatrelvir + Ritonavir 👯 2️⃣ 300mg (2 tabs) Nirm + 100mg (1 tab) Rit BID x5d 🗓️ 3️⃣ Nirm: Protease inh to SARS-CoV-2-3CL; blocks viral reproduction 🛑 4️⃣ Rit: Slows metabolism of Nirm 🐌 5️⃣ Shows in vitro activity against previous variants AND Omicron🤞
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