Timothy Brown

@ItIsMikeFitz Afrezza will probably remain the latest and greatest breakthrough in insulin from here on out. Big Pharma is no longer in the game of insulin therapies, only weight loss, following the money. I just wish big pharma would stop showering healthcare with rebates, cornering market

@asyled childrenwithdiabetes.com/clinical-direc…

$MNKD "Afrezza" Inhalation Powder for Type 1 diabetes, Diabetes, Type 2 diabetes for Pediatric - PUDFA Approval set for May 29. $MNKD has many drugs upcoming in the pipeline. This is a company to watch.

📅 PDUFA COUNTDOWN: Afrezza pediatric — May 29, 2026 $MNKD — MannKind Corporation FDA decision on sBLA to expand Afrezza (inhaled insulin) to children & adolescents ages 4-17 with T1D or T2D. Why this matters: • If approved → FIRST needle-free mealtime insulin for pediatric patients • Inhaled insulin has been available to adults for 10+ years. Zero needle-free options exist for kids. • Based on Phase 3 INHALE-1: 52 weeks of safety/efficacy data, Afrezza + basal insulin vs. MDI • INHALE-1ST trial (newly diagnosed peds T1D) also enrolling ~100 patients The needle burden in pediatric diabetes is real. Multiple daily injections in a 4-year-old is a different clinical reality than in adults. 14 days out. ⏳ $MNKD | PDUFA May 29

@PDUFA_Pulse childrenwithdiabetes.com/clinical-direc…

$MNKD next Friday. PDUFA May 29, Afrezza peds T1D/T2D ages 4–17. PoA 72%. Cleanest debate on the board: • INHALE-1 missed HbA1c noninferiority on full ITT • Defense rests on modified analysis excluding one nonadherent patient • Pulm function, weight, satisfaction all support FDA call is whether the sensitivity case holds.

#Afrezza #T1D #Diabetes Parents and kids, we’re likely only a couple weeks away from FDA approval of Afrezza for under 18. Yes, inhalable insulin, but that’s not even the greatest part. Join the Fb Afrezza users group for more life changing info, that no Endo will tell you.

#Afrezza Just another angle I hadn’t shared. Afrezza provides me with the highest quality of T1D life! Diabetes management is still on my mind 24/7, but it’s different with Afrezza. With Afrezza, I am in control. I have the power to Take Control of my diabetes.

@Muramasatrades @Baegopuda111 @HolySmokas childrenwithdiabetes.com/clinical-direc…

Afrezza for adults is already FDA approved and commercial 👀 May 29 is the PDUFA date for pediatric approval. Afrezza for kids 4-17. If it passes, first needle-free insulin option for pediatric patients ever. Then July 26 Furoscix ReadyFlow Autoinjector PDUFA. Two catalysts in 3 months. Thesis very much intact.

Not enough to buy $TSLA stock... 🤷‍♂️ What stock under $309 should I buy? lmk!

@ItIsMikeFitz Afrezza will probably remain the latest and greatest breakthrough in insulin from here on out. Big Pharma is no longer in the game of insulin therapies, only weight loss, following the money. I just wish big pharma would stop showering healthcare with rebates, cornering market

Where will it end

#Afrezza #T1D #Type1Diabetes #AbetterGameofDiabetesManagement

@ItIsMikeFitz When you say, “Pure protein,” are speaking of a protein sparring modified fast? High protein, low fat, zero carb?

Thinking about adding carbs back as a #T1D? Here’s what actually works (from someone who went LCHF/keto to carnivore to high carb): First expect a transition phase. If you’ve been low carb, your body is adapted to fat. When you add carbs back, you’ll likely see bigger spikes and need more insulin at first. That’s normal! It’s basically the Randle Cycle and low carb adaptation. Give it 2-3 weeks before judging anything... Just like it takes time to adapt to keto/low carb, it also takes time to adapt back to higher carbs. Your body doesn’t flip a switch overnight. There’s an adjustment period! Here’s what I did: Add carbs gradually. Don’t go from 30g to 300g overnight. Step them up over days/weeks. I personally started with adding more fruit like citrus and apples. Keep fat LOW (very important). I'm talking 0.2g-0.3g/ pound body weight. High fat AND carbs yields VERY poor glucose uptake, delayed spikes (think of what happens to our sugars when we eat pizza for example). Lower fat makes carbs behave WAY better. Center carbs around training Pre/intra/post workout yields the highest insulin sensitivity (GLUT4). Best time to handle carbs. Be ready to adjust insulin UP (temporarily). You may need more at first. As you adapt, this usually improves. Stay consistent. Your body adapts to what you do repeatedly. What I found: Low carb with small carbs yields unpredictable spikes. Higher carb with low fat yields way more stable, predictable control. I maintained great A1Cs both as low carb and high carb, but felt way better and performed better when I added carbs back in. You don't necessarily have to be "high carb", you could take a more middle of the road approach and just dial it up until your individual needs are met. One thing that stayed consistent no matter what I was doing (low carb or higher carb) was high protein. That never changed. It supported my recovery, muscle, and overall stability regardless of how I structured carbs and fats. Personally I feel pure protein is massively underrated as a dietary intervention for glycemic control. At the end of the day, this isn’t about being "low carb" or "high carb" It’s about finding the balance that lets you feel good, perform well, and keep your blood sugars predictable.

@DrBikramDash @Cipla_Global Click on the clinically reviewed and published article above

@Rollertb @Cipla_Global @Rollertb Share your Afrezza Using experience here . If you are feeling better or Satisfied.

Afrezza can be the way more better but still satisfied with the result of my multiple patients feed back & result. Try to avail Afrezza 4 here sufficiently @Cipla_Global

@Bladeandbarrel @mbamcnulty childrenwithdiabetes.com/clinical-direc…

@mbamcnulty the Tyvaso DPI cough isn't just the drug, its the inhaler that requires a deep, fast inhalation and the particles that are uneven and misshapen. The excipient that Mannkind uses causes cough in 30% of patients with diabetes with Afrezza

$LQDA Wells Fargo put out a good note covering a few topics and a price target raise from $44 to $51 Some of my thoughts Firstly, they speculated that $UTHR $MNKD future once-a-day inhaler could be an inhaled version of ralinepag. If true, I think it’s a similar playbook to what $GOSS tried to do with Seralutinib, the inhaled route having lower GI side effects than the systemic oral version. In the PH3 trial serious AEs dropped from 44% (oral imatinib) vs 16%, but that was traded for 37% cough. Different molecules but I guess the logic tracks. Very high execution risk for a 2028 launch. On $UTHR SMI, Wells Fargo called out real clinical data comparing Respimat (SMI) vs HandiHaler (DPI) cough rates were similar (~4.7-8.4% vs ~5.8%) in COPD. So the real world evidence for the cough advantage is thin. The 90% cough reduction quoted was in healthy volunteers and as RJ has called out this doesn’t necessarily translate to real world patients. WF see the SMI mainly cannibalising Tyvaso Nebuliser, it’s ultimately just a more convenient form factor. A regulatory approval strategy for bio equivalence means it’s probably designed to deliver the same low dose /exposure (only 9-12 breaths Tyvaso breaths) Yutrepia already has a manageable cough profile and can dose 2-3x higher which we know delays disease progression! I really don’t think doctors are going to bother with this. They also believe the market is under appreciating L606. Their argument is what we already know is true with Yutrepia, more treprostinil exposure equals better efficacy and L606’s PK data suggest it can deliver comparable or potentially superior exposure to TPIP. The trade off being 2 times a day but with a better AE profile. They raised their price target to $51 on the back of the L606 taking more market share.

@BornFree_isms childrenwithdiabetes.com/clinical-direc…

On average 150 injections a month- just to not die. The burnout is real 😞 #T1D

@BornFree_isms @ItIsMikeFitz Where are you located? I know two Australians whom found means to obtain and legally use Afrezza, and one gentleman in UK whom obtains Afrezza from NHS.

@ItIsMikeFitz You get all the fun. We don’t have it approved here.

The eating required wasn’t easy, the diabetes management however was, thanks to Afrezza!

Continued: Dudes over 6’ weighing 250+. I’m 5’8” and 221 pounds today. A fellow gym goer, Abe, whom I have much respect for put the peer pressure on me to get where I am at, and I had a positive consequence.

#Afrezza This morning, 21-days before my 48th birthday, I joined the 405 club! While 315 to 335 lbs has been a given to me for 20+ years, I never thought I’d ever be able to reach 405 lbs. The few people in my lifetime I’ve witnessed hit this, have all been genetic freaks.

Newest PR, 395 lbs. at a body weight of 218. 405 is the goal, then I will lean out for summer. #Afrezza