Roman Schimmer

To the incredible healthcare professionals who remained behind to care for patients while your colleagues attended the #ASH24 congress in San Diego, we extend our deepest gratitude. Your dedication and selflessness ensure that patient care remains a constant priority, even as the field advances through events like this #ASH24 . Thank you for your compassion, and for keeping the heart of healthcare beating strong. @ASH_hematology @TheIACH @COMyCongress @Mohty_EBMT

Congratulations to #Jonas Fullin from my lab @Unispital_USZ @UZH_en @CCCZ_USZ presenting his data on #TP53 allelic states in #AML #ASH24 @ASH_hematology 👏🎉

@NicoGagelmann PCH

Young patient presents with anemia and is yellow😳 Diagnosis?

If patients with aggressive blood cancer have a certain mutation, novel immunotherapies do not work. Researchers from @UZH_en and @Unispital_USZ have discovered this mechanism – and found ways to overcome the resistance. Acute myeloid #leukemia (AML) news.uzh.ch/en/articles/me…

Our March issue is online! 🌺 This month's cover by @DrawImpacts highlights the article by @TheBoettcherLab that shows that TP53 mutations in #AML confer resistance to #CARTcell therapy ➡️embopress.org/toc/17574684/1…

!!! PAPER OUT in @EmboMolMed !!! #TP53-mutant #AML is notoriously hard to treat. Immunotherapies might be a promising therapeutic option. Ever wondered what the impact of the #TP53-mutational status on #CARTCell efficacy in AML is? doi.org/10.1038/s44321… A 🧵1/n

Authors report the successful and safe off-label administration of caplacizumab during pregnancy and urgent delivery in a patient with refractory iTTP buff.ly/48wpegr @RomanSchimmer

@grichardmd @Dr_AmerZeidan @MikkaelSekeres @DanielleHammo20 @sanamloghavi @Ramikomrokji @GMontalbanBravo @garciamanero Would go for HSCT, even more so since Len has been shown to select for TP53 mutants

Looking for advice/thoughts! 🧐 60 y.o. woman with MDS with isolated del(5q), BM blasts 3%, Hb 100 g/L, ANC 1.0, Plt 350, TP53 mut with VAF of 30%. How would you treat? @Dr_AmerZeidan @MikkaelSekeres @DanielleHammo20 @sanamloghavi @Ramikomrokji @GMontalbanBravo @garciamanero

@nihardesai7 @BrownJHM @nihar_nayak2 @DoctorBhavsar @chandrachud_n @Nischistocyte @Dishaar88241487 @adiv2711 @HemOncFellows @MorphologyAmigo @HaemBytes Vyxeos - liposomal daunorubicin & cytarabine

65/♂️/ newly diagnosed AML is receiving this drug 👇🏻 🟣🟣🟣🟣🟣🟣🟣🟣🟣🟣🟣🟣🟣🟣🟣 Name the drug !! #MedTwitter

@DocsDock200 IgM against I

The Ab above most likely is:

66 yo female presents with fatigue and tea-colored urine. Hgb 8.9 g/dL, retic 9.2%, LDH 2.5x normal, BR 2.1. WBC and Plts normal. MCV 110. DAT + for C3d, - IgG. The antibody responsible for this condition is most likely...

@BloodJournal @benoit_tobias

Introduction to a How I Treat series on management of high-risk patients following allogeneic transplant loom.ly/0L1J8UY

Congrats @RomanSchimmer on his dual achievement: First-author paper"#TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms" published in @BloodAdvances & his doctoral degree. Well done, Dr. Schimmer! @UZH_en @Unispital_USZ @CCCZ_USZ