Rosetta Commons

What do high-quality, well-documented datasets and protein design tutorials have in common? These amazing researchers! At our first Megathon, participants worked all week long at a Data Bazaar and Tutorial Hackathon to create resources that can be used in the Rosetta Commons community and beyond. bit.ly/476wS2z

European RosettaCon invites researchers in protein design, biomolecular dynamics, advanced microscopy, and structural determination methods to “cross boundaries in protein design” together. Join us to reach beyond traditional frontiers and into interdisciplinary approaches. europeanrosettacon.org

Computational protein modeling and design is a rapidly evolving field, with new emerging methods, tools, and applications. Each year, the Rosetta community gathers to explore where the science is heading next by exchanging ideas and sharing new work at Summer RosettaCon. Early bird registration closes March 31! rosettacon.org

Program: europeanrosettacon.org/program-2025/ Virtual registration: pretix.eu/SBD/RCon2025/

In-person registration for #EURosettaCon closes tomorrow morning -- we’re excited to welcome 260 attendees for an incredible program! 🎉🎉🎉 It’s going to be an amazing conference. If you have not registered, don’t worry, you can still join us virtually! 💻

🚨 Exciting news! 🚨 The speaker lineup for EU RosettaCon 2025 is live: europeanrosettacon.org/program-2025/ 🎤 Incredible talks await — join us in person or online! 🔗 Virtual registration: pretix.eu/SBD/RCon2025/

🚨 Three days left to register for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓. We are working hard to select talks and finalize the schedule. Due to popular demand, we also have a virtual option! 15 EUR for academic and 90 EUR for industry participants.

Science update: Designer Proteins Boost the Performance of Titanium Implants. Baker lab introduces NeoNectins, which help the body respond to surgical implants, healing gels, and other biomaterials. The study was led by postdoctoral scholar Xinru Wang, PhD, and visiting researcher Jordi Guillem-Marti, PhD Quick read: rosettacommons.org/2025/06/26/des…

We'd like to thank our generous sponsors for making Summer RosettaCon 2025 a successful event. Your support fueled innovation, collaboration, and community. Our sponsors for this year: Vilya , Lila Biologics, @Merck, @novoprotein , and Levitate Bio LLC. Explore these companies and discover the outstanding work they do.

Members of the IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of the de novo design of macrocyclic peptides that bind proteins with nanomolar affinity and remarkable precision. This work is based on a report from June 20, 2025, in Nature Chemical Biology Read more here: rosettacommons.org/2025/06/26/int…

Registration for Biomolecular Modeling and Design with Rosetta and ML Tools Workshop (November 17th – 19th, 2025) is now open. The goal of the workshop is to educate and train academic and industry users on the Rosetta software suite. Explore more: meilerlab.org/tutorials/

We're excited to introduce our #RaMP 2025-2026 cohort. Watch this space for more updates.

RFdiffusion: Beta Documentation Now Available We’re excited to announce that RFdiffusion now has official, Rosetta Commons-curated documentation! Read more: rosettacommons.org/2025/07/16/rfd…

We listened to your feedback. Proscuplt is: *Easier to install - now uses use containers 🚀 *Easier to run in SLURM - specify queue & task details directly in the prosculpt YAML file. github.com/ajasja/proscul… Big thanks to @FAOlivieri_, @Alina_K_KI, Nej Bizjak, and Žan Žnidar🙏

We’re making a few intentional changes to our US-based Rosetta conferences next year to better support our growing community. We want to hear what you think. Learn more about the changes: rosettacommons.org/2025/06/26/loo… Share your thoughts: docs.google.com/forms/d/e/1FAI…

Rosetta Commons Biosecurity Fellowship now accepting proposals This 12-month remote fellowship offers a unique chance to shape how protein design tools are developed and governed. Fellows lead their initiative, engage directly with Rosetta Labs and policy experts, and help bridge science and policy around biosecurity. Learn more here: rosettacommons.org/2025/06/26/ros…

50% and higher experimental success rates would be a game changer and absolutely amazing. I just hope it's not a training set leak or some other artifact (since binders to all of these have been designed before). Hope the scientific community can get access soon to test.

News from the Rosetta community: Prosculpt – an open-source library integrating RFDiffusion, ProteinMPNN, AlphaFold2 & Rosetta into one easy workflow More via @AjasjaLjubetic: rosettacommons.org/2025/05/28/all…