Ryan Ceddia

VUMC-led team reports potential new way to stimulate weight loss news.vumc.org/2024/05/31/vum…

This study shows Gβγ-signaling exerting control over physiology by regulating neurohormone exocytosis. The Gβγ-SNAP25 interaction is a potential drug target, and targeting this pathway that modulates neuroendocrine signals would be a unique approach to treating metabolic disease.

Zack Zurawski and Simon Alford developed a method to measure norepinephrine release from sympathetic neurons in inguinal adipose depots. Using this method, we show that inguinal fat pad sympathetic neurons from SNAP25Δ3/Δ3 mice have enhanced and prolonged norepinephrine release.

Check out our new JCI paper (a thread) Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity jci.org/articles/view/… @hamm_heidi

Researchers, including senior authors @hamm_heidi and Sheila Collins, PhD, have uncovered a potential new way to help curb the rapidly rising worldwide prevalence of metabolic disorders, including obesity and diabetes. Published in @jclinicalinvest. spr.ly/6015PIoRB