S3 Ventures

@GainsightHQ went from losing hours after every customer call to 3x more closed-won dollars per SE hour — and with @tryopine as their single source of truth, presales, leadership, and the product team are now all aligned. Learn more about their implementation with @tryopine👇 tryopine.com/case-studies/g…

🎤 The @SACCTEXAS hosted @ericengineer and @henriksven of @MadeWithGembah earlier this month for a great discussion on the state of #VentureCapital across the U.S. and #Texas. Thanks @SACCTEXAS for including us 👏 and putting on a fantastic evening!

🎉 We're proud to share that we've co-led Earlytrade's Series A, taking their total raised to $25M to scale agentic AI across construction payments! Construction generates over $2 trillion in annual US output, yet hardworking subcontractors often wait 60–90 days for payment. Earlytrade is closing this gap. EarlyTrade operates a marketplace that lets general contractors pay their subcontractors early using their own working capital, giving subcontractors faster access to the money they're owed, enabling stronger contractor supply chains. Since launching in the US in 2024, Earlytrade has grown revenue 7X, expanded its network to 211,000+ subcontractors, and facilitated $3B+ in early payments globally. We're honored to be backing co-founders Guy Saxelby and Piers Symons alongside @BrickMortarVC! Full story in the comments 👇 #ConstructionTech #FinTech #SeriesA #AgenticAI #ConstructionPayments

🎉We're proud to co-lead Advanced NanoTherapies' $31M oversubscribed Series B! Restenosis after coronary intervention remains one of cardiology's most persistent challenges and outdated therapies often fail to deliver durable results. Advanced NanoTherapies' SirPlux Duo DCB uses a proprietary nanoparticle system to deliver two proven antiproliferative agents directly into the vessel wall, achieving higher potency at lower doses while leaving nothing permanently behind in the vessel. Exclusively licensed from @ClevelandClinic and FDA Breakthrough Designated, SirPlux Duo has completed a first-in-human study in 28 patients with two-year follow-up showing no new treatment failures. The company is conducting an ongoing 30-patient feasibility study in Spain mirroring the U.S. pivotal protocol. We're proud to back this exceptional team alongside a strategic co-lead and continued support from T45 Labs and existing investors.  Full story in the comments👇  #MedTech #SeriesB #SirPluxDuo #DrugCoatedBalloon #InterventionalCardiology #VascularIntervention

@AdvancedNanoT 🎉We're proud to co-lead Advanced NanoTherapies' $31M oversubscribed Series B! Restenosis after coronary intervention remains one of cardiology's most persistent challenges and outdated therapies often fail to deliver durable results. Advanced NanoTherapies' SirPlux Duo DCB uses a proprietary nanoparticle system to deliver two proven antiproliferative agents directly into the vessel wall, achieving higher potency at lower doses while leaving nothing permanently behind in the vessel. Exclusively licensed from @ClevelandClinic and FDA Breakthrough Designated, SirPlux Duo has completed a first-in-human study in 28 patients with two-year follow-up showing no new treatment failures. The company is conducting an ongoing 30-patient feasibility study in Spain mirroring the U.S. pivotal protocol. We're proud to back this exceptional team alongside a strategic co-lead and continued support from T45 Labs and existing investors.  Full story in the comments👇  #MedTech #SeriesB #SirPluxDuo #DrugCoatedBalloon #InterventionalCardiology #VascularIntervention

🎉 Having led @ArpioRPO's Seed, we are excited to double down and co-lead their $15M Series A with @Paladincap—alongside @DraperVC, Uncorrelated, @valorvc, CreativeCo Capital, and Lookout Ventures! Big congrats to Doug Neumann, Shaw Terwilliger, and the entire Arpio team! Arpio’s cloud resiliency platform enables enterprises to validate and recover critical workloads with unparalleled speed and ease. Learn more 👉 businesswire.com/news/home/2026… #CloudResilience #Cybersecurity #DisasterRecovery #AIInfrastructure

🏥 CEO Spotlight Now Live! Denis Harrington, President & CEO of @VMG_FLEX, found his way into vascular medicine after graduating from West Point and serving time in the Army. It became his life's work. With 30+ years in vascular device commercialization, Denis has led organizations of 1,800+ people, guided companies through acquisition, and now leads the team behind the FLEX™ Vessel Prep System — a fundamentally different approach to lesion preparation that is redefining what's possible in endovascular care. In our latest CEO Spotlight, Denis shares his journey from Army officer to medical device executive, what it means to build technology around a clinician's frustration, and where he sees AI reshaping the future of vascular intervention. Read the full interview to hear Denis's perspective on mission-driven leadership and the next frontier of medical device innovation. 🔗 s3vc.com/news-and-insig… #CEOSpotlight #Leadership #MedTech #VascularHealth #HealthcareInnovation #MedicalDevices

@MythicInc businesswire.com/news/home/2026…

🎉 Congrats to @MythicInc on acquiring Videantis GmbH, one of Europe's leading digital processor IP companies with 25M+ chips shipped worldwide! This acquisition expands @MythicInc's hybrid #AI compute platform — delivering 100x greater energy efficiency over conventional GPU-based systems.  Full story in the comments👇  #AICompute #EdgeAI #DeepTech #Semiconductors

Last week, we had the privilege of co-hosting some of the most inspiring female founders and CEOs in #AustinTech. From incredible bites to a breathtaking performance 🎶 by Maren Morris at The Moody Theater—this is what community in #Austin looks like. Thank you to Amee Ly and Eli Kaplan of @justworks, our very own @nicole_a_bentz, and Addie Olsen Rasche of Silverton Partners for hosting — and to all who shared their evening with us: Abby Coleman, Amela Kraja, Ashley Beeler, Carolyn Lowe, Connie Lee, Corina Kellam, Jacqueline Karlin, Jana Montgomery, LaTecia Johnson, Neha Shivnani, Rachel Balke, Sarah Hampton, Stephanie Guttman, Vanessa Heppner #FemaleFounders #WomenInTech #S3Ventures

Congratulations to @SuiteStudios_io and the @Adobe - Frame.io team on @Frame_io Drive being named a #BestofShow 🏅 award winner at the 2026 @NABShow! 🎉 Read more here 👇 tvtechnology.com/events/tv-tech…

Thank you to all the venture investors who attended our dinner with @LiveOakBank at Raleigh's Michelin award-winning 🥂 Mala Pata Molino + Cocina. 🌮 The founders, startups, and investors in North Carolina continue to impress, which is why we've backed four incredible companies across the state: @allstacks, @repvue, @ArpioRPO, and most recently, @tryopine. We can't wait to see what visionary founders and ideas emerge next from this thriving ecosystem. 🚀 Special thanks to @tweeterwee and Matt Sallese for co-hosting and making this one to remember for all our attendees: Daniel Coley, @davidstjones, Greggory Bordes, Jackie Lipkin, @jcaplain, @mrostick, @M_Bressler, Michael Wooten, Pat Scheper, Sonali Sanjay, Trent Myers, and Yash Mehta

During #SaaStockUSA on Tuesday @charlieplauche took the stage, breaking down #tech trends every #SaaS investor should have on their radar. Big thanks to @SaaStock for putting on a great event!

@SuiteStudios_io @Frame_io @Adobe blog.frame.io/2026/04/15/int…

@SuiteStudios_io file streaming technology is now the engine behind @Frame_io Drive, an @Adobe company, giving creative teams real-time access to media from any location. This is an infrastructure shift the industry has been waiting for. Congratulations to Craig Hering and the entire @SuiteStudios_io team on this milestone! 🎉 #FrameDrive #FileStreaming #MountedStorage Read the full story in the comments 👇

🎉Congratulations to @rosezhong and the entire @GetSudozi team on their acquisition by Zone & Co! Rose founded @GetSudozi to solve the challenges she faced firsthand as a 3-time CFO, with finance teams flying blind on spending decisions, until invoices landed on their desks. @GetSudozi was built to move finance into the decision-making process — centralizing purchase requests, automating vendor management, and embedding AI-driven procurement intelligence throughout vendor intake, purchase requests, and approval workflows. By joining Zone & Co, Sudozi's procurement intelligence will plug directly into the AI-powered financial operations platform already trusted by 4,000+ companies nationwide. It has been a privilege to be part of @GetSudozi's journey since our initial investment in 2021, and we can't wait for what's next. Read more here 👉 zoneandco.com/newsroom/zone-…

🎉 Portfolio Announcement: S3 Ventures is thrilled to announce our continued investment in @EndovascularEng (E2), who closed an $80M oversubscribed Series C co-led by @GildeHealthcare and @NorwestVP, to transform the standard of care for #PulmonaryEmbolism. CEO Dan Rose and team have built the Hēlo® Thrombectomy Platform — combining clot-breaking and suction in a single streamlined catheter to tackle #VTE, the third leading cause of cardiac-related death, doing more in one pass where legacy systems fall short. Honored to support E2 alongside @GildeHealthcare, @NorwestVP, Santé Ventures, 415 Capital, @panakes, and M&L Healthcare Investments. Learn more 👉: prnewswire.com/news-releases/… #MedTech #VTE #Thrombectomy #PulmonaryEmbolism