SCCM Midwest Chapter
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SCCM Midwest Chapter
@SCCMMW
Not for profit organization - Educate, Innovate, and Network for future of Critical Care. Visit us at https://t.co/kyV6I2n3El
Katılım Temmuz 2019
307 Takip Edilen325 Takipçiler
SCCM Midwest Chapter retweetledi

I just read this outstanding review by Prof. Michael Pinsky:
👉 “The Effective Management of Shock: From Physiology to Guidelines to Personalized Medicine”
🧠 Key paradigm shift:
👉 Shock is not about numbers
👉 It is about tissue perfusion and cellular metabolism
⚠️ Three brutal truths (often ignored in daily practice):
1️⃣ Once organ injury occurs → we cannot reverse it
→ We can only limit further damage
2️⃣ Monitoring alone does not improve outcomes
→ Only actions linked to effective therapies matter
3️⃣ Guidelines ≠ patient care
→ The clinician’s physiologic reasoning remains central
📊 Why many “standard” approaches failed:
Targeting DO₂ “supranormal” levels → ↑ mortality
EGDT bundles → not superior to good early care
Fixed 30 mL/kg fluids → harmful in non-responders
👉 Lesson:
One-size-fits-all resuscitation is physiologically wrong
🫀 Modern hemodynamic thinking:
✔️ Fluid responsiveness matters (PPV, SVV, PLR)
✔️ MAP alone is not enough
✔️ Focus on:
Tissue perfusion pressure
Critical closing pressure (Pcc)
“Vascular waterfall” concept
👉 Increasing MAP ≠ improving microcirculation
🔥 Game-changing concept:
👉 Shock = failure of microcirculatory flow regulation
Even with:
Normal CO
Normal MAP
➡️ Tissue hypoxia may persist
🧬 The real goal of resuscitation:
❌ Normalize numbers
✅ Restore effective tissue perfusion early
✅ Avoid iatrogenic harm
💡 Where we are going:
Capillary refill time (CRT)-guided resuscitation
Personalized MAP targets
Dynamic physiology-based decisions
AI-driven precision resuscitation
📌 Take-home message:
👉 The future of shock management is NOT:
More fluids
More drugs
More devices
👉 It is: Better understanding of physiology + individualized care
🧠 And maybe the most important sentence in the paper:
👉 “The thoughtful bedside clinician remains the gold standard.”
#CriticalCare #Shock #Hemodynamics #ICU #Sepsis #PersonalizedMedicine #Resuscitation #Pinsky

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Wondering where the data stands on Stress Ulcer Prophylaxis? Our upcoming FREE Virtual Webinar with Critical Care Pharmacist Rebecca Hilton will be discussing exactly that!
Wednesday, 4/22 at 6pm CST.
RSVP REQUIRED: Email SCCMMWC@gmail.com to claim your spot!

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Meet ICU Pharmacist Morgan Ridout, a member of the Midwest Chapter's Communications Committee. We had the opportunity to ask Morgan a few questions. Check out her answers below!
Interested in joining SCCM - Midwest Chapter? Email sccmmwc@gmail.com to learn more!

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SCCM Midwest Chapter retweetledi



