School of Life Sciences, Peking University

New insights into complement activation! Cryo-EM structures from Prof. Junyu Xiao’s lab reveal how C4b2a and C3bBb engage C3 in classical/lectin & alternative pathways, respectively (2.6-3.1 Å). Key to disease & drug development!science.org/doi/10.1126/sc… #ComplementSystem #CryoEM #Immunology #PKUResearch

New study from Junyu Xiao’s lab: Human FcRL5 is a unique IgG receptor! Cryo-EM reveals it grabs TWO Fcγ molecules to bind immune complexes & internalize them. Time to rethink IgG receptors beyond the canonical FcγRs! #PKU #PKUResearch #SLSPKU science.org/doi/10.1126/sc…

Xiong Ji's group revealed that FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation. #PKUResearch science.org/doi/full/10.11…

Congratulations to Prof. Deng Hongkui and Prof. Qu Lijia from the School of Life Sciences at Peking University on their election as academicians of the Chinese Academy of Sciences (CAS)!

Zhe Zhang’s group presents cryo-EM structures of the glucose-6-phosphate transporter SLC37A4—whose defect causes glycogen storage disease type Ib—in multiple functional states, revealing its mechanisms of substrate transport, inhibition, and pathology. doi.org/10.1038/s41594…

Breakthrough in biologics engineering! Research from Junyu Xiao's lab decoded the hexameric structure of frog IgX via cryo-EM & hacked human IgM/IgG to form super-efficient hexamers. #PKUResearch doi.org/10.1126/sciadv…

Peking University Life Sciences -- A Century in the Vanguard. Welcome to watch the documentary of Peking University Life Sciences.📺 @PKU1898 @SLSPKU

Ph.D. Programs at Peking University School of Life Sciences Admissions for 2026 Are Now OPEN💗 Welcome to the School of Life Sciences at Peking University. Let’s embark on a journey together to unravel the mysteries of life! @PKU1898 bio.pku.edu.cn/en/index/index…

He Yu's group and their collaborators revealed the geographic and temporal origins and subsequent dispersal and admixture of pigs in East Asia, mirroring human migration and agricultural development history. @PKUResearch doi.org/10.1093/molbev…

Xiong Ji's group reveals that INO80/SWR remodelers regulate gene expression by reshaping chromatin landscapes and modulating BRD2 binding, rather than through H2A.Z dynamics. #PKUResearch academic.oup.com/nar/article/53…

Hsiang-Ying Sherry Lee’s group and collaborators uncover how composite transposons (SVAs) with dual histone marks act as RNA-dependent regulators to drive erythropoiesis, steer blood lineage commitment, and shape hematopoietic aging. #PKUResearch cell.com/cell/fulltext/…

RNA circularization is key for circRNA therapeutics. Wensheng Wei' s lab unveils PIET & CIRC. Using intact self-splicing introns, CIRC generates circRNAs efficiently — even large RNAs encoding full-length dystrophin. #PKUResearch nature.com/articles/s4146…

Symposium on RNA: Mechanisms and Therapeutics Focus on recent advancements in RNA mechanisms and therapeutics. Ready to join us? #PKU #PKUResearch 🗓️September 25-27, 2025 📍JW Marriott, 83 Jian Guo Road, Chao yang District, Beijing Register Now: meeting.csbmb.org.cn/PKU_RNA_FORUM.…

Deng and colleagues pioneered a robust chemical reprogramming method to directly convert human blood cells into pluripotent stem cells.#PKUResearch doi.org/10.1016/j.stem…

Structural study reveals how CD163 forms calcium-dependent oligomers to bind Hb–Hp complex, facilitating ligand uptake via endocytosis. #PKUResearch nature.com/articles/s4146…

A novel receptor for AAV (AAVR2, carboxypeptidase D), which is distinct from the multi-serotype AAV receptor (AAVR) has been discovered and characterized. #PKUResearch cell.com/cell/fulltext/…

How are cilia built? Using cryo-ET, @QiangGuo_EM and team captured basal body biogenesis & axoneme assembly in mouse ependymal cells at sub-nanometer resolution. #cryoET #TEAMTOMO #PKUResearch nature.com/articles/s4146…

Peking University scientists decode RNA's "dark matter" to expand the genetic code, precisely programming protein function for next-gen therapeutics. #PKUResearch doi.org/10.1038/s41586…

Prof. Wensheng Wei's lab employed high-throughput screening based on prime editor at both population and single-cell levels to identify and characterize functional synonymous mutations in human cells. #PKUResearch nature.com/articles/s4158…