Sam Witus

Awesome paper by @SWitus64671 and @RapeLab showing a new mode of allosteric feedback regulation of nucleotides through PPAT/NUDT5 complex. Explains longstanding paradox that PPAT feedback inhibition seemed to require supraphysiological nucleotide levels. nature.com/articles/s4158…

@Denis_V_Titov @RapeLab Thanks, Denis!

@richeslab Thank you, John!

This weeks recommended paper is by Samuel Witus and Michael Rapé +team who show that purine nucleotides stabilise the PPAT–NUDT5 complex to provide feedback control of purine biosynthesis, while thiopurines exploit the same interface with greater potency: nature.com/articles/s4158…