Sabine Brinkmann
17.1K posts
@Sabine_BC
Training over 50, knitting, and cats
Overtrained a bit this week - realized I haven’t had a true rest day in almost 3 weeks. Whoops. So today we’re just making more orthoceras fossil pendants and binge watching Antiques Roadshow. I’d never seen it prior to today - Amazon was like “hey we think you’d like this” and I’m like “oh hay you’re right.” Sometimes the algorithm gets it right.
What if AI could invent enzymes that nature hasn’t seen? 👩🔬🧑🔬 Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design 14 rounds of directed evolution and over a year of wet lab work. That's what it took to engineer an enzyme for selective C(sp³)–H insertion, one of the most challenging transformations in organic chemistry. DISCO surpasses this with a single plate. No pre-specified catalytic residues, no template, no theozyme, no inverse folding, just joint diffusion over protein sequence and structure. 📝 Blog: disco-design.github.io 📄 Paper: arxiv.org/abs/2604.05181 💻 Code: github.com/DISCO-design/D…
Be honest, what’s missing here
