Dr Sam Rowe

Congratulations to @HarryWilders and the team for getting this exciting ‘Direct-to-Biology’ work out there! We generate cysteine-targeting chloroactemide reactive fragments and screen them without purification to optimise inhibitors of SARS MPro. onlinelibrary.wiley.com/doi/10.1002/an…

A pleasure to act as @JessCrompton’s Industrial Supervisor over the past year or so. She is an incredibly hard-worker and it’s wonderful to see that work rewarded with this nice publication in @JOC_OL 😊 If you need cyclopropyl acids, look no further! pubs.acs.org/doi/10.1021/ac…

Our latest paper in collaboration with @GSK describes how the reactivity of a series of SuFEx reagents influences covalent modificaiton of the proteome. Congratulations to @KateGilbert_ , @Jake_T_Bush and @arronaatkar . pubs.acs.org/doi/10.1021/ac…

Just posted a photo @ Wien, Österreich instagram.com/p/CeHhFimIsrkh…

@Cochrane_lab Agree! It’s so cool 😎

Updating my peptide synthesis notes and have to give this beautiful work another shout out. Such an innovative and effective method. Are there any other total syntheses of lasso peptides out there? pubs.rsc.org/en/content/art…

@KateGilbert_ Huge congrats, Kate 🥳

So excited to share our work profiling sulfonyl fluorides as powerful functionalities for chemical biology - chemrxiv.org/engage/chemrxi…

I'm searching for a PhD student to start in my brand new lab @UniofBath in Oct 2022. The project will use phage display for covalent ligand discovery. Retweets are much appreciated. findaphd.com/phds/projectde…

Great to see this nice piece of work out there! Understanding the mechanisms of bacterial drug transport is going to be crucial in the coming years for overcoming the growing #antimicrobialresistance crisis. nature.com/articles/s4200…

Time for another pharmacology tweetorial, this time on the distinction between IC50 and Ki. 1/

Graduation ✅

Nice to be at my first in-person conference in over 2 years! Hearing great talks about peptide chemistry. Looking forward to applying some of these strategies to my own work #BiologicsUK

Reviewer looking for the figures at the end of the manuscript

@DPSynthChemist 😂😂

If it needs chemistry discovered after I was born, we probably shouldn’t be making it, amide and Suzuki couplings always work, let’s stick to what we know.

Congratulations to Ross Thomas and the team for this great work published in @ChemicalScience on accelerating PhABit design-make-test cycles using high-throughput chemistry. 🐇💫 #chembio #reactivefragments #covalentmodifiers pubs.rsc.org/en/content/art…

Nickel complex dying in 3...2...1... #RealTimeChem

Have you seen 'The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions' by David Spring & first author, Bee Ha Gan? @SpringGroupChem @ChemCambridge Don't miss it #OpenAccess👇🔓xlink.rsc.org/?doi=D0CS00729C

@NicolaAshman6 Congrats!

Can't complain with this as a poster prize!

2nd dose done! Feeling very grateful and proud to be a scientist (not that I have anything to do with vaccines…)

Really nice paper showing synthesis of enantioenriched amides through N-alkylation rather than N-acylation using a dual copper catalytic cycle. nature.com/articles/s4158…