Sam Orange

I'm excited to share our latest work showing that exercise rapidly triggers molecular changes in the blood that act directly on colon cancer cells to remodel gene expression and promote DNA damage repair Full text: onlinelibrary.wiley.com/doi/10.1002/ij… BBC coverage: bbc.co.uk/news/articles/…

"Even a single workout can make a difference." @SamOrange01 @UniofNewcastle sciencealert.com/10-minute-burs…

Link to the study. onlinelibrary.wiley.com/doi/10.1002/ij…

Just 10 minutes of vigorous exercise can halt cancer cell growth. When colon cancer cells from obese/overweight adults were exposed to post-exercise serum and given a small dose of radiation, the cells had fewer markers of DNA damage and an overall faster DNA-repair response. The serum also raised PNKP, a gene that helps fix DNA. Looking at gene activity, the cancer cells increased mitochondrial energy pathways and dialed down cell-cycle and proteasome pathways, basically shifting toward energy use and away from rapid division. The post-exercise blood also had higher levels of 13 proteins (including IL-6 and its receptor), indicating systemic activation of immune and vascular signaling pathways. This helps paint a clearer mechanistic picture of why exercise seems particularly effective at reducing colon cancer risk.

New preprint: Exercise-conditioned serum enhances double strand break repair, upregulates DNA repair gene PNKP, and induces transcriptional changes that reflect increased mitochondrial metabolism and reduced proliferation in colon cancer cells. biorxiv.org/cgi/content/sh…

We're seeking expertise in supportive/sports bras for exercising after breast surgery. This will be paid consultancy work (0.5-1 day). If you have the expertise & are interested, please email sam.orange@newcastle.ac.uk.

My PhD student is looking for volunteers near Edinburgh for this study investigating how ageing affects our immune system- take a look 👀!

Insights into the future of studying Physical behaviour: ProPASS is the engine— harmonising thigh & wrist sensors in prospective studies for policy-ready, globally-relevant evidence. Read this provocative piece from @dmg_pa & colleagues. cell.com/action/showPdf…

🚨 3-year Post-doc opportunity at the Centre for Nutrition, Exercise and Metabolism, @CNEM_Bath @UniofBath Opportunity to lead on an RCT involving symbiotic supplementation and ketogenic diets bath.ac.uk/jobs/Vacancy.a… Building in our prior work pubmed.ncbi.nlm.nih.gov/39106867/

We're delighted to share that @UniofNewcastle has officially approved renewal of the #NUCancerCentre for 2025-30. We look forward to continuing this important journey together over the next five years.

@CameronHill13 Not yet Cameron - yes please that would be awesome 🙏

@SamOrange01 Did you manage to get this? I have full access s can send if needed still

Can anyone access the full-text for this paper please? The V˙E/V˙co2 Slope During Maximal Treadmill Cardiopulmonary Exercise Testing: REFERENCE STANDARDS FROM FRIEND pubmed.ncbi.nlm.nih.gov/33470730/ sam.orange@newcastle.ac.uk - thank you

Excellent postdoctoral research opportunity beginning Sept/Oct 2025. NEWDAY-ABC is a multi-centre PA & dietary hybrid intervention-implementation trial in early breast cancer patients funded by Yorkshire Cancer Research. Further details here: jobs.hull.ac.uk/Vacancy.aspx?r…

A huge thank you to our incredible speakers at Research & Innovation in Health – a Collaborative Approach @HI_NENC @pcourtceo @FelicityShenton @SamOrange01 @ProfessorIoann1 @SarahAudsley @Gabrielcucato #HealthInnovation #Healthworks30 #NENC

⭐️Come and join our team ⭐️ Our brilliant Sport & Exercise Science team are looking for a new lecturer. Interested? Check out the link ⬇️ 🔗: jobs.ac.uk/job/DMW740/lec…

Standing room only at today's workshop! 26 women with breast cancer worked together to agree what exercise instructors need to know when delivering physical activity programmes to women during and after treatment. This is part of our ongoing research: breastcancernow.org/our-research/r…

More people are living with and beyond breast cancer than ever before, but fatigue and low mood are common—even after treatment ends. Dr @SamOrange01 is working to remove barriers to exercise by working with community health services. 🔗 Learn more: breastcancernow.org/our-research/r…

🙌Launching our new PPI Groups🙌 We are very excited to be hosting our first #colospeed PPI groups later today! There is still time to sign up - click the link to read more about our aims to improve bowel cancer screening, diagnosis & treatment: forms.office.com/e/DarD6RaUh7

🔎Shaping #bowelcancer Research🔍 The #colospeed research group is being set up to involve patients & the public in our research design & delivery. See how you can get involved to improve bowel cancer screening, diagnosis & treatment: bit.ly/40Bz2Ej @SBRFoundation