Samuel Kilcher

101 posts

Samuel Kilcher

@SamuelKilcher

Designer of genomes, phage enthusiast, rock climber, views are my own.

Zurich, Switzerland Katılım Ocak 2018

50 Takip Edilen413 Takipçiler

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Samuel Kilcher@SamuelKilcher·18 Şub

I am thrilled to announce that PhalconBio has secured £1 million grant funding from @PACE_AMR to propel our lead anti-Pseudomonas program. Thank you for the support and recognition of our platform technology! 🚀💪🥂 #phage #engineering #AMRsolutions phalconbio.com/news/pace

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Samuel Kilcher@SamuelKilcher·15 Eyl

Urine Good Hands! Engineered phages to detect and treat #UTIs. 🙏 to @phagedirectory for publishing an interesting behind-the-scenes article. 🙏@MattDunne_1 Jiemin Du @MeileSusanne @MartinLoessner @PhageForward @LeitnerLorenz Thomas Kessler and team! phage.directory/capsid/urine-g…

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Samuel Kilcher@SamuelKilcher·24 Tem

What happens when you combine two #precision #antimicrobials? ➡️Enhanced #UPEC killing using #engineered #phages that release a #colicin from infected target-bacteria! ➡️See effect of this two-pronged attack in green (supplementary data from rdcu.be/dhi2D)

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Samuel Kilcher retweetledi

ETH Zurich@ETH_en·21 Tem

Pathogens that cause urinary tract infections #UTIs are becoming increasingly resistant to #antibiotics. ETH researchers developed a rapid test and a new therapeutic approach using bacteria-infecting viruses known as #phages.@SamuelKilcher @MattDunne_1 fal.cn/3A4Gy

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Samuel Kilcher@SamuelKilcher·20 Tem

2 papers out @NatureComms: #Engineered #phages to detect (rdcu.be/dhi2N) and treat (rdcu.be/dhi2D) #UTIs. Big team effort! 🙏🙏🙏 to @MeileSusanne Jiemin_Du @MartinLoessner @MattDunne_1 + >20 contributors @eth_en @derbalgrist @UZH_en Pic: Happy last authors 😀

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Samuel Kilcher@SamuelKilcher·6 Ara

Help us bring engineered phage therapy to life! We are looking for a motivated research scientist to join our @Micreos antimicrobial vector innovation team in Switzerland. You can find more details here: linkedin.com/jobs/view/3389… (Application through LinkedIn)

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Samuel Kilcher@SamuelKilcher·25 Kas

For #phage #engineering geeks: If you are interested in modifying the genomes of virulent #Enterococcus phages, you may want to have a look at Figure 2 of our recent preprint. 🧬Cas9 is a highly efficient counter-selection tool 🧬 🧬100 % success rate🧬 biorxiv.org/content/10.110…

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Samuel Kilcher@SamuelKilcher·25 Kas

Great study covering many applications of phage engineering. Congrats! Really enjoyed seeing in vivo data comparing wildtype vs. replication-deficient phages 👍

Hiroki Ando 安藤弘樹@Ando169

Congrats to our team! Synthetic engineering and biological containment of bacteriophages. pnas.org/doi/10.1073/pn…

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Samuel Kilcher@SamuelKilcher·24 Kas

Proud to present our work on engineered #phage-based urine #diagnostics. Huge team effort led by @MeileSusanne Jiemin Du @MattDunne_1 + much support from @LeitnerLorenz @PhageForward Thomas Kessler @MartinLoessner + 16 more authors! @ETH_en @derbalgrist biorxiv.org/content/10.110…

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Samuel Kilcher@SamuelKilcher·14 Mar

Nice phage engineering work-around for phiKZ-like jumbo phages!

Joe Bondy-Denomy@joeBondyDenomy

Here, @jingwen_guan presents a new way to engineer phage genomes, using Cas13a + an Acr protein! We developed this because our favorite jumbo phage, phiKZ had no genetic tools. We are now using this to understand the jumbo phage secrets. short🧵biorxiv.org/content/10.110…

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Samuel Kilcher@SamuelKilcher·10 Mar

@MattDunne_1 @ETH_en I echo that! And a big thank you to the students @ETH_en, to @marschall_jonas, and to @PhageForward for help and fruitful discussions. We are grateful to the patients and the clinical care team @derbalgrist for providing urine to test our phage antimicrobials!

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Matthew Dunne@MattDunne_1·10 Mar

Our preprint on #engineering #phages is out now. A huge thank you and congratulations to our phage engineering team at @ETH_en 👏🏼.

Samuel Kilcher@SamuelKilcher

How to tackle #UTIs with engineered #phage? Proud to present: biorxiv.org/cgi/content/sh…. Big shout-out to first authors Jiemin Du + Susanne Meile and co-corresponding @MattDunne_1. Thanks @LeitnerLorenz, Thomas Kessler, and @MartinLoessner for all the support! @ETH_en @derbalgrist

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Samuel Kilcher@SamuelKilcher·10 Mar

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Samuel Kilcher retweetledi

Matthew Dunne@MattDunne_1·16 Haz

Out today👨‍🔬! Characterization of tail fibers and tailspikes from broad range E. coli #phages EP335 and EP75. Shout out to co-authors Sander Witte & Joel T. van Mierlo @Micreos, @LeaZinsli, Cassie Matter & @MartinLoessner @ETH, & Rafael G-Serrano. 👏 sciencedirect.com/science/articl…

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Samuel Kilcher@SamuelKilcher·16 Ara

Nothing cheers me up more than marveling at cumulative incidence curves of the Pfizer/BioNTech and Moderna vaccines 😅 #VaccinesWork

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Samuel Kilcher@SamuelKilcher·11 Ara

Excited to share our thoughts on improving #phagetherapy through #synbio and genome engineering: authors.elsevier.com/sd/article/S09… Congrats to the 2 first authors @FlyGeneticsGuy and Bryan Lenneman and to @MartinLoessner and @timlu for a great collaboration. Artwork by @FlyGeneticsGuy

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Samuel Kilcher@SamuelKilcher·1 Ara

@MattDunne_1 Time to get out of crystallography? 😅

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Matthew Dunne@MattDunne_1·1 Ara

How long until X-ray crystallography and EM are just pages in science history books 🙈😢? Incredible news yesterday from #CASP14 about #AI-based structure determination. Will lab-based structure solving be used just to confirm what 🖥s can do? bbc.com/news/science-e…

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Samuel Kilcher retweetledi

The Nobel Prize@NobelPrize·7 Eki

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

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Samuel Kilcher@SamuelKilcher·25 Eyl

@MercerLab Looks a bit like when we arrived 😅

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Jason Mercer@MercerLab·24 Eyl

The end of an era! Looking forward to seeing you @unibirmingham @IMIBirmingham

Laura Pokorny@laurapokorny

Saying goodbye to our empty lab at the LMCB today. Now to look forward to joining the other mercenaries and seeing what the @IMIBirmingham has to offer for the next few months!

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Samuel Kilcher@SamuelKilcher·24 Eyl

Another great example of phage-antibiotic synergy, congrats! Phage-resistance often comes at a cost: incrased antibiotic susceptibility, decreased virulence, etc... #CombinationTherapy

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Samuel Kilcher retweetledi

PHD Comics@PHDcomics·22 Eyl

Happy Postdoc Appreciation Week

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Keşfet

@phagedirectory @MattDunne_1 @MeileSusanne @MartinLoessner @PhageForward @LeitnerLorenz @NatureComms @ETH_en