Sasha Gusev

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Sasha Gusev

Sasha Gusev

@SashaGusevPosts

Statistical geneticist | Associate Prof at @DanaFarber / @harvardmed / @DFCIPopSci | Blogging at https://t.co/4D7UObBNdd

Katılım Ocak 2023
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
I've written about race, genetic ancestry, analyses of large biobanks, and human history #h.v8wagygagcry" target="_blank" rel="nofollow noopener">gusevlab.org/projects/hsq/#… I'll summarize the key points here 🧵:
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
@AlexTISYoung No they're not, but I think that's my point. There are problems in comp bio that if solved/improved would be seen as meaningful (and merit high impact publications) even if they were openly solved by an LLM -- because they produce tools that have inherent utility.
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Alex Strudwick Young
Alex Strudwick Young@AlexTISYoung·
@SashaGusevPosts Do these count as 'open problems' though? I'm not sure the problems are as well defined as in math. Sure making better methods for problem X is important but not quite the same thing as solving an open math problem.
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
This highlights how other fields are more vulnerable to AI disruption than math. A computational biologist carefully writing out open problems and then using an LLM with, say, a 10% success rate, to scan through them could single-handedly make meaningful scientific contributions.
Daniel Litt@littmath

For now I think recent successes of AI for mathematics should be understood as a complement to, rather than a substitute for, human mathematical labor. This is because AI, at present, is most productive working horizontally, whereas humans work vertically. By this I mean that the highest quality AI mathematics thus far has been obtained by feeding entire problem lists into a model or scaffold and picking out the few high-quality successes. It is very hard to predict in advance where these successes occur. On the other hand, humans typically pick a few questions and try to understand them deeply--and historically, when they do so, they make progress! I think this points to increasing value of problem lists, and also suggests that "solved an open problem" is an increasingly useless proxy for what we care about in mathematics. There are a lot of problems that have sat open for a long time because the right person didn't happen to look at them, and many others that are open because they benchmark our failure to fundamentally understand some basic object. I've solved old open problems that I think had the former flavor rather than the latter. I think my best work, however, is not about solving long-open problems, but rather inventing a new ones that help to understand something we care about, and making progress on that.

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Jack
Jack@tracewoodgrains·
@SashaGusevPosts @QiaochuYuan got it. I wouldn't be surprised if it persisted on the top-end ones, but it's tough for me to draw too strong of conclusions from Sonnet
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
@tracewoodgrains @QiaochuYuan Sonnet 4.6 (which is my default Claude model). All models I tested produced some kind of response like this (typically less egregious), though the code-based ones could be forced to test it and find that it was not statistically robust.
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
@tracewoodgrains @QiaochuYuan Yesterday I fed one thousand randomized abstracts into Claude and asked it to identify themes by gender/race. It wrote a multi-page report about how minority authors focus on DEI topics.
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Jack
Jack@tracewoodgrains·
@QiaochuYuan the post is poetic and fun, as with much of his work, but I worry the rhetoric outruns the substance when current models don't fall into the failure states he says they fall into
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
The big question is whether using an LLM to pick the 10% low hanging fruit makes it much more challenging to pick the high hanging fruit.
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
If an LLM produced a substantially more efficient aligner or a more accurate genomic deep learning algorithm or a better single-cell eQTL test we would still very much care about these outputs.
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
@worst_account @Benthamsbulldog Every American may be owed reparations for slavery, but in proportion to their exposure to the "pollutant". In fact that seems like the more just implementation.
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Charles G. Koch 🏴
Charles G. Koch 🏴@worst_account·
@Benthamsbulldog My main issue with Boonin's view is that he doesn't carefully distinguish tortious & non-tortious harms, but instead seems to just treat any case of being worse-off if-not-for as one -- which seems to mean *every* American is owed reparations for slavery. x.com/i/status/20585…
Charles G. Koch 🏴@worst_account

@Benthamsbulldog The gist of Boonin's view: imagine a pollutant released 100 years ago still having new effects -- these harms would be after the births of the harmed, even though the *source* of the harm was before those births, so there's no non-identity problem. Plausibly, slavery is the same.

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Sasha Gusev retweetledi
Marios Georgakis
Marios Georgakis@MariosGeorgakis·
A new approach enables imputation of structural variants from widely available SNP data, potentially unlocking the integration of structural variants (SV) in classical GWAS analyses. In UK Biobank, imputed SVs contributed <5% of heritability for most traits.
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Cassie Pritchard
Cassie Pritchard@hecubian_devil·
Such a silly argument for so many reasons. One, wouldn’t out-of-training data be *less* likely to trigger the detector? Two, aren’t the LLMs writing the prose similarly biased? It’s such a shame that a certain kind of institutional liberal instinctively reaches for identity as a shield in situations like these. It’s really damaging for when people need to actually talk about discrimination.
Joe Weisenthal@TheStalwart

There seems to be an accusation here that @pangramlabs only used work that comes from the “dominant culture” and therefore it’s unreliable at measuring text used in the context of this prize, which aims to reward underserved communities.

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Anup Malani
Anup Malani@anup_malani·
Take 2 students with identical SAT scores & academic records. One grew up in the top 1%, the other in the middle class. The top-1% student is 34 percentage points more likely to be admitted to an Ivy-Plus college, even controlling for academic preparation.
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
Recall that LLMs were used by DOGE to flag grants for funding termination.
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Sasha Gusev
Sasha Gusev@SashaGusevPosts·
Fed some random abstract - name combinations into Claude and asked it to look for gender trends. Surprise surprise, Claude finds a clinical versus computational split ...
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