Very grateful to work as part of a collaborative team led by Denise Wootten & Patrick Sexton and for generous collaborators who provided us with cell lines they generated (I'm not good at twitter and don't know how to tag sorry, 5/5).
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Samantha McNeill 💡🔬💊
411 posts
Samantha McNeill 💡🔬💊
@Scientist__Sam
Passionate scientist with a huge appreciation for the small things in life (like proteins).
Katılım Kasım 2019
918 Takip Edilen538 Takipçiler
Interestingly, we also observed that beta arrestin 1 recruitment to the GLP-1R was more sensitive to GRK expression than beta arrestin 2 recruitment (4/n).
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However, until this paper, it remained to be determined whether GRKs were essential for GLP-1R internalisation. By using cells which lack beta arrestins or GRKs, we reveal that the GLP-1R internalises via a GRK-dependent, but beta arrestin-independent mechanism (3/n).
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Unlike many other GPCRs, the GLP-1R has been established to internalise via mechanisms that do not require beta arrestins (2/n).
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Very excited to share our most recent publication: sciencedirect.com/science/articl…. Do you like GRKs and the GLP-1R?! Then this paper might be worth a read (1/n).
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Samantha McNeill 💡🔬💊 retweetledi
The final version of our manuscript including structures of PTH1R bound to five peptides is live in @Structure_CP! @MIPS_DDB @CCeMMP
Structure@Structure_CP
Online now! Molecular insights into peptide agonist engagement with the PTH receptor dlvr.it/Snmbwb
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Samantha McNeill 💡🔬💊 retweetledi
Save the date! We are excited to once again bring together the international GPCR community to share the latest in #GPCR research. Mark your calendars for November 15-17th, to join us at @MIPS_Australia
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@NerdyCammy Oh wow! I can't believe star trek day has come around so quickly this year 😂
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Samantha McNeill 💡🔬💊 retweetledi
This piece by @SarahJ_Piper (@PiperProteins) from @MIPS_Australia and @CCeMMP, was runner up for the NHMRC Science to Art Award. ‘Atomic Jewellery’ shows the atomic structure of a receptor, which helps inform research for the development of therapeutics for diabetes and obesity.
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@ppelvazhao @MIPS_DDB They clearly heard the rumour of how great you are :).
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Samantha McNeill 💡🔬💊 retweetledi
I hated doing PCRs 🧬 as an undergraduate… Now, as a postdoc, I’ve done thousands of PCRs 🧬… Here are 10 tips to do perfect PCRs:
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Samantha McNeill 💡🔬💊 retweetledi
We depend on external validation whether we admit it or not. After the @NobelPrize I feel more free, care less about external validation (duh!), and enjoy the process of discovery even more. In retrospect, I think I should have been able to achieve some of this without the Prize!
Dr. Shefali Mehta✨@Shef0121
@NobelPrize I'd ask the coolest laureate @ardemp that does the way you look at and do science change after you become a laureate? ..and have you ever felt disinterested in science as a consequence of academic toxicity or any other reason? If yes, how do you cope with it?
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Grateful for this bunch! Here's to more science-filled lunches in 2023
Elva Zhao@ppelvazhao
Positive feedback from our very first lawn conference : "Thanks to the organising committee inviting all of us plenary speakers. The event was filled with great debate, including the allocation of Spongebob characters to members of the lab ;) we all learnt a lot!" @MIPS_DDB
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@PatrickMSexton1 Great sampling of the free energy landscape of conference attendees
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This is a very refreshing discussion around leadership in science #Echobox=1675511640" target="_blank" rel="nofollow noopener">nature.com/articles/d4158…. Working in science is a privilege, but also a big responsibility. The ability to listen to others and acknowledge when mistakes are made is vital to leadership.
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