Sébastien Rigali

From spelunking to new #antibiotic discovery! Fantastic work in collaboration with HEDERA-22. Lunaemycins, first new bioactive molecules found from cave moonmilk-dwelling #Streptomyces. See our work at lnkd.in/egHScnTx. @Strep_papers @saveantibiotics

Very excited to share our latest work published in mBio showing that Strepto can use glucose from any plant heteroside thanks to a unique 'swiss army knife' enzyme! DOI: 10.1128/mbio.00935-22

New voracious enzyme from Strepto: Structure and function of BcpE2, the most promiscuous GH3-family beta-glucosidase for scavenging glucose from heterosides biorxiv.org/content/10.110…

Old Enzyme, New Role: The β-Glucosidase BglC of Streptomyces scabiei Interferes with the Plant Defense Mechanism by Hydrolyzing Scopolin mdpi.com/1417312 #mdpibiophysica via @MDPIOpenAccess

The virulome of Streptomyces scabiei in response to cello-oligosaccharide elicitors | Microbiology Society microbiologyresearch.org/content/journa…

Transcription awakening by a Genetic compensation phenomenon. pubmed.ncbi.nlm.nih.gov/32758700/

On the Risks of Phylogeny-Based Strain Prioritization for Drug Discovery: Streptomyces lunaelactis as a Case Study mdpi.com/766056 via @MDPIOpenAccess

@Streptomyces2 Prodiginine production and programmed cell death in S. coelicolor. frontiersin.org/articles/10.33…

My 50th publication is out today!! 😃 frontiersin.org/articles/10.33…

Complete Genome Sequence of Streptomyces lunaelactis MM109T, Isolated from Cave Moonmilk Deposits. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/29798921

#mdpiantibiotics Isolation, Characterization, and Antibacterial Activity of Hard-to-Culture Actinobacteria from Cave Moonmilk Deposits mdpi.com/274880 @antibioticsmdpi

#mdpiantibiotics High-Throughput Sequencing Analysis of the Actinobacterial Spatial Diversity in Moonmilk Deposits mdpi.com/274660 @antibioticsmdpi

Prodiginine Production in Streptomyces coelicolor Correlates Temporally and Spatially to Programmed Cell Death disq.us/t/2y9d85c

Cracking the Regulatory Code of Biosynthetic Gene Clusters as a Strategy for Natural Product Discovery out now! :-) authors.elsevier.com/sd/article/S00…

Listen to Elio Schaechter commenting our work on Moonmilk Streptomyces. :-) TWiM #157: Back to the ancestor schaechter.asmblog.org/schaechter/201…

@Streptomyces2 Moonmilk Strepto and how they make mineral deposits. journal.frontiersin.org/article/10.338…