Shaney Wright

6 years

@michael_hoerger There's no correction made for multiple testing?

One way to make a device look like it has a benefit is to examine 60+ outcome variables and then only focus on the 2-5 that are statistically significant by chance (sampling error). Pharma/device companies have been doing this for decades...

@drmfreire This must be at least the 50th study demonstrating long-term SARS-CoV-2 spike persistence and it's pathogenic consequences. I just wonder if there'll ever be anything done or indeed do-able about it

What is persistent #SARS-CoV-2 Spike doing in gut tissue in situ? In our new preprint, we used spatial transcriptomics, RNAscope, GeoMx DSP, and multiplex IF to investigate biopsies from #LongCOVID The immune dysfunction happen on spike + regions of LC. biorxiv.org/content/10.648…

We found that Spike⁺ regions show: • immune cell remodeling • suppressed chemokine signalling • epithelial stress programs In LC tissue, these regions display transcriptional signatures resembling tumorigenesis, Crohn’s disease–associated pathways, and #chronic #inflammation

Haven't posted much about Long Covid of late. 6yrs on, it's just so disappointing: That researchers did nothing with billions. Failure to strike while iron was hot. Lack of appreciation of what Covid (still) does to people. Zero treatments. Etc etc etc. Truly, that's all I have.

What I have realized recently is that researchers’ interest in Long COVID seems to be fading. It is probably the exhaustion of trying to pursue studies without funding. We already felt at the edge of an abyss. Now it feels like we are shoveling into it.

In case anyone doubts that FND is just a new way of saying “conversion disorder” here is the article where they discuss needing a new name for it.

Nearly six years into #LongCovid. Patients still have: 💕No validated diagnostic tests 💕No proven treatments 💕No clear prognosis But there’s been no shortage of conferences, career building, fundraising, awards, and branding. At what point do we demand outcomes over optics?

@OliDugmore Well said. It's always a case of 'who should pay for it then!?', all the while having graduates going their entire working lives lumbered with a 9% tax (whether working in the UK or moving abroad) on top of already high income tax & national insurance rates is just fine & dandy.

Who should pay an extra 9% of income tax? 1. Someone earning £125,000+ 2. A young graduate on £25,000 The British government’s answer will shock you!

@tomhfh Yes, if uni were to be made free, but in the meantime, there's a lots of things that can be done inbetween, such as getting rid of the ludicrous interest rates being charged.

If we want university fees and their associated Grad Tax to be cut, we need a hell of a lot fewer people going to university. When it was entirely taxpayer subsidised, <10% of people went to university. When fees were finally introduced, it was to cover this number more than tripling to 33%. Today 50% go, and fees had to rise to cover that.

@KevinJTraceyMD Our paper exploring this topic as it relates to #POTS, #MECFS and #LongCOVID just came out today! dovepress.com/postural-ortho…

For years we thought the immune system was “autonomous.” It isn’t. It's controlled by nerves just like all the other organs. The vagus nerve sends signals that can switch inflammation on and off.

@BenKentish @RachelReevesMP This issue demonstrates how politicians are more than happy to tolerate and defend gross, blatant unfairness so long as they feel that doing so is more convenient/easier than not doing so, on balance. Until it's capable of producing major, felt political heat, it'll remain as is

Hi again @RachelReevesMP - I got this today from a young doctor from a low-income family. She can’t afford to buy a house because, while she’s paying back £2,560 in student loan repayments a year, you’re charging her interest at a rate of £7,800 a year. Which part of this is “fair”?

@WorldByWolf I agree with your sentiment, but nonetheless, doesn't justify interest rates on student loans being the ridiculously high level they are.

Dugmore, like many socialists, gets the diagnosis right but the solution wrong. You can make university free by only allowing the top 10-15% to go and only for certain courses. You can’t have free university when you let over half of people go with most studying dud courses.

@TheWealthDr AI splurge

A Japanese Manager Once Told Me: “We Fire Employees Who Arrive on Time.” I laughed. Then he explained why—and it completely changed how I see success. I first heard this in Tokyo during a business dinner. I asked why being late is such a serious offense in Japan. He replied calmly: “We don’t fire the late ones. We fire the ones who arrive exactly at the start.” The table went silent. In my culture, arriving right on time means: • responsible • disciplined • professional In his culture? It means passive. He explained: “If you arrive at 9:00 sharp, you’ve waited until the last possible second.” That tells us something important. It tells us you didn’t plan for: • traffic • delays • uncertainty • responsibility beyond yourself And if you don’t plan for uncertainty… you can’t be trusted with systems. He said something I’ll never forget: “Only the weak arrive in the last minute.” Not because they’re lazy—but because they think in limits, not margins. Japanese companies don’t value accuracy. They value anticipation. A professional arrives early to: • settle the mind • read the room • prepare mentally • show readiness Not to rush in out of breath. That idea stayed with me. And once I noticed it… I couldn’t unsee it. The most successful people everywhere, no matter within which country: • arrive early • stay calm • observe first • speak last They’re already present before others even enter. They build trust before the meeting begins. They notice details others miss. They create opportunity before others react. That edge compounds. Showing up early isn’t about time. It’s about mindset. Exactly on time says: “I did the minimum.” Early says: “I came prepared for reality.” Business, and life, require margin. When someone says, “But I came on time,” I no longer hear discipline. I hear the limit of their thinking. Japan understood this long ago: Success begins before the clock starts. Will Americans and Germans and many others relearn these self-explanatory principles? The question going forward is: Will YOU continue with the behavior of the Have-Nots, or choose the behavior and success of the Have-Yachts? Bitcoin. 🟠

@philrandal @BenKentish Indeed

@ShaneyWright @BenKentish They already do by virtue of their higher pay compared to non-graduates

If the British media covered issues affecting different generations equally and fairly, the student loan scandal, which will see young people robbed of many thousands of pounds, would be top of every single news bulletin and on the front of every single newspaper - just like when wealthier pensioners faced losing £200 a year in Winter Fuel Payments. But it doesn’t and so it won’t be.

@BenKentish To add to this; it's not just a de facto graduate tax but an international graduate tax. The only other countries in the world to have international taxation of their citizens are the US and Eritrea.

@BenKentish I think the notion that graduates should pay something back is reasonably arguable but the sheer size of the sums & the enormous, grossly unfair interest rates are just wrong in every way. It's a de facto 35year long graduate tax, paid on top of income tax & national insurance.

@lewis_goodall @ShelaghFogarty On this, agree with you 100%.

Spoke to @ShelaghFogarty yesterday sbout why the Chancellor is wrong: our “student loan” system is not remotely fair. It’s regressive and embedding inter and intra generational wealth inequality. It’s not a loan system, it’s a bad grad tax in all but name. youtu.be/uOC6Arrf2us?si…