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Shea Stickel
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Shea Stickel
@SheaStickel
22 y/o student of life, health, and mitochondria. IG: https://t.co/DCcGwn9E7n
Read on Substack Katılım Eylül 2025
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Chris Palmer, MD — on what impairs mitochondria:
- Poor sleep / circadian disruption
- Chronic stress
- Ultra-processed food
- Substance use: alcohol, cannabis, tobacco, some meds
- Hormonal imbalances
- Poor gut health
- Lack of purpose
- Chronic inflammation
- Physical inactivity
- Nutrient deficiencies
- Loneliness
- Unresolved trauma
(List not exhaustive)
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Shea Stickel retweetledi

Timing *is* everything — and nature's ultimate yin-yang is blue + red light. Not blue alone or manmade light.
Blue (cool, high-energy, “yin”) wakes us up and sets the circadian clock. Red/NIR (warm, penetrating, “yang”) fuels mitochondria and restores order at night.
Plants figured this out billions of years ago: chlorophyll absorbs almost exclusively in the blue and red bands, and the light-harvesting complexes use **quantum coherence** to route that energy with >95 % efficiency — a “quantum walk” that explores every pathway simultaneously and lands on the perfect one. Zero waste.
We’re made of the same stardust. When we live in the same blue/red balance as the plants, our biology works the same way.
Carefull what light you live under— and read @DrJackKruse.
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Johan@LetterToLive
A most read!
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Shea Stickel retweetledi

Douglas Wallace's mitochondrial paradigm is prob the most important framework in medicine that nobody in mainstream practice uses.
Chronic disease is an energy problem (not one gene centralized bs).
- mtDNA sits right next to the electron transport chain
- No histones protecting it
- Minimal repair capacity
- Mutation rate x10-17 higher than nuclear DNA
BUT heteroplasmy (mito mutations) accumulates, and this is the KEY puzzle piece,
When dysfunctional mitochondria cross a threshold in a given tissue, that tissue begins fails. High ATP demand tissues go first and you see this reflected in chronic disease distributions.
Brain → neurodegeneration
Heart → cardiomyopathy
Beta cells → T2DM
Immune cells → chronic inflammation
Teh upstream dysfunction is similar.
You essentially just get a different diagnostic label depending on which tissue hits the threshold first.
Modern environmental mismatches drive this process.
- ALAN nuking melatonin (your most potent mitochondrial antioxidant).
- Processed seed oils driving cardiolipin remodeling in the inner mitochondrial membrane.
- Micronutrient depletion starving the ETC of its cofactors (CoQ10, B2, B3, iron-sulfur clusters, copper)
= accelerating heteroplasmy accumulation while simultaneously degrading the inputs mitochondria need to function and coordinate physiology.

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Send to a friend who needs to fix his sleep schedule 🌄
And read the full article on my Substack:
open.substack.com/pub/sheasticke…
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