Spyridon Siafis

抗精神病薬の臨床試験データを調べ直し、「adverse eventによる脱落」 として報告されている脱落の過半数が精神症状の悪化による脱落であり、「adverse eventによる脱落」が抗精神病薬の副作用の評価指標としては不適切であることがわかりました。　doi.org/10.1016/j.euro…

メタアナリシスの実施だけでなく、GRADE評価も補助してくれるようにしました。メタアナツールの中で一番便利なはず yukifurukawa.jp/pmatools/

@GuyattGH Hi, I made a web app that allows you to perform meta-analysis and GRADE evaluation. I hope you'll like it yukifurukawa.jp/pairwise-meta-…

Just #published in @NatMentHealth: Clozapine works best early! • 81% response in non‑TRS • 63% in TRS ❗️Drops from >90% at onset to ~46% by year 10 💡Early use may improve outcomes; chronic patients can still benefit nature.com/articles/s4422… @myrto_samara @ElizPnt @SiafisS

統合失調症に対する抗精神病薬の至適用量を調べた用量反応メタアナリシスをアップデートしました。eClinicalMedicine、筆頭です。 sciencedirect.com/science/articl…

Get Primed on Schizophrenia with our NEW PrimeView! FREE to download this week! nature.com/articles/s4157…

Our NEW Primer on Schizophrenia is live today! By Leucht, Siafis, McGrath, McGorry, Howes, Tamminga, Carr, Bighelli, Schneider-Thoma, Priller, Davis. Check it out here: nature.com/articles/s4157…

1/ 📢 Just published in eClinicalMedicine! We reviewed 150 RCTs (11,375 patients) to compare pharmacological treatments for treatment-resistant schizophrenia. 🔗 doi.org/10.1016/j.ecli… @myrto_samara @LeuchtStefan @ElizPnt @IwoFober @SiafisS @dimi_mavridis

1/ 📢 New research: we’ve conducted the most comprehensive analysis of treatments for ADHD in adults, including pharmacological, psychological, and neurostimulation approaches. Here’s what we found — and what it means for treatment decisions. 🧵 thelancet.com/journals/lanps…

@nomuranobuyuki Although long way, it was nice travelling together =)

ニュルンベルクに向けてまっすぐ南下せず、謎の迂回路を通るのが謎だった。

GALENOS wants to hear from you! What are the research questions you want answered about anxiety, depression and psychosis? We want to hear from researchers, clinicians & people with lived experience from all around the world. Fill out the survey here👇 docs.google.com/forms/d/e/1FAI…

Interested in doing a PhD in biostatistics??? We are hiring!!! Come to Bern to work in the project “Evidence synthesis methods to predict personalized treatment effects” funded by the @snsf_ch Details on how to apply in the link ohws.prospective.ch/public/v1/jobs…

Do you want to learn how to carry out & publish a network meta-analysis? Come to @UniofOxford (23-25 Jun 2025) & join our NMA course with hands-on statistics, writing sessions & tips for publication oxforduniversitystores.co.uk/conferences-an… Discounted fees for students/NHS staff & junior academics

@PsychAustin @NEUROSEC_Ox @OxfordBRC @OxPsychiatry @GALENOS_Global @OxfordPPL Good start, Charlotte!

Excited to be starting a new role at @NEUROSEC_Ox working on the @OxfordBRC Flourishing and Wellbeing Theme, continuing at @OxPsychiatry Thank you for all the support from @GALENOS_Global and @OxfordPPL over the last year

A new method to combat publication bias in mulitlevel #metaanalyses - led by amazing Yefeng with a great team (e.g. @DanielWANoble @coraliewilliams) besjournals.onlinelibrary.wiley.com/doi/10.1111/20… This method has some better properties than Egger regression-based methods, which are more widely used.

Using a population rather than case control sample massively reduces impact of CNVs on psych disorders. 22q del associated with HR of 3 for schizophrenia (rather than 80 in case-con), and 22dup not found to be protective jamanetwork.com/journals/jamap…

@Toshi_FRKW providing a touching "autobiography" of his scientific work, and what we can learn from it - great read! ajgponline.org/article/S1064-…

Placebo response varies substantially in size across mental disorders Correlates of ⬆️ placebo responses in multiple disorders includes later publication year (except ADHD), younger age, more trial sites, larger samples, increased baseline severity & active tx effect size 🧵👇

From our umbrella review, just published in @molpsychiatry. This is the largest synthesis to date of placebo and treatment response across mental disorders in pharmacological and neurostimulation RCTs nature.com/articles/s4138… Some thoughts...

🚨Postdoc Opening🚨 We're seeking a skilled scientist to lead research in multiomics❗️ Join our excellent interdisciplinary team👇in our efforts to tackle pressing challenges in cardiovascular disease Lab: georgakis-lab.isd-muc.de Position: findapostdoc.com/search/Job-Det… Please RT!