Simon Mathis

@goodwin_ml Wow fantastic - congratulations to the fractile team!

I am thrilled to share the news that Fractile's mission to build chips and systems that unlock the next generation of AI scaling has been bolstered, with a $220M funding round led by Accel, Factorial Funds, and Founders Fund, alongside some incredible backers old and new. AI inference is driving the defining infrastructure buildout of the 21st Century. We've written a bit about where we think capabilities must go, and how Fractile is working to bring this about: fractile.ai/news/fractile-… It has been a privilege working on one of the hardest but most rewarding technical challenges of our time for over three years, with the most brilliant, kind and driven people I could have ever hoped to work alongside. We are still just getting started. There is a lot to be done to deliver on our goals, but we are grateful to have the support of so many people in chasing these down every minute of every day. Thanks, all, for being part of the Fractile mission! 🚀 @fractile_ai

Today we're launching Latent-Y: the world's first autonomous agent for drug design, lab-validated end to end. Give it a research goal. Latent-Y reasons, designs, iterates, and delivers lab-ready antibodies, autonomously or collaboratively, with the biological reasoning of a PhD protein design expert. Technical report: tinyurl.com/latent-y-techr… Blog post: latentlabs.com/latent-y Apply for access: platform.latentlabs.com

Join us next Tuesday and ask questions/discuss research!

📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;) Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation. Project page: research.nvidia.com/labs/genair/pr… 🧵 1/n

Introducing Latent-X2 — AI-generated antibodies with drug-like developability and low immunogenicity in human panels, zero-shot. Technical report: tinyurl.com/latent-X2-repo… Blog: latentlabs.com/latent-x2 Apply for access: partnerships@latentlabs.com

Lots of gems in there - can highly recommend checking it out! Thank you for all the great work @chaitjo and for making it so accessible

@Latent_Labs @RenPhilanthropy @NeurIPSConf Many thanks also to the UK Sovereign AI Unit @SciTechgovuk for the invitation!

Today at 11am I’ll present some of the exciting work in AI x Bio we’ve been up to at @Latent_Labs at the @RenPhilanthropy booth (Hall A/B, booth 1343 @NeurIPSConf - straight through the entrance at the back left). Come say hi!

@Latent_Labs @RenPhilanthropy @NeurIPSConf If you can't make it at this time, we're at neurips for the next couple of days - reach out to me or any of our team if you're interested catching up over coffee. There'll also be an event on Saturday: x.com/saakohl/status… Looking forward to many interesting conversations 🙌

@Latent_Labs @RenPhilanthropy @NeurIPSConf Thank you @RenPhilanthropy & @charlieharris01 for hosting us!

Today, we report a method for design of active enzymes, RFdiffusion2, in @naturemethods. For the first time, we are able to design enzymes with native-range catalytic activity. We also are releasing our next frontier model, RFdiffusion3, code 👇

Congratulations @chaitjo - so exciting!

Come do a PhD with me 😀! Promise of fun science and great coffee ☕

🚨New package alert! 🧬 Introducing Pocketeer: A lightweight, fast protein pocket finder in pure Python! I built this as a Pythonic version of fpocket because I wanted something that could easily calculate subpockets. > pip install pocketeer Link at end of the thread 🧵(1/7)

Super cool - congratulations Magnus & Team!

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.

We asked ourselves what could we do if we worked cooperatively as a team to create a single model that could design any biomolecular interactions. Yesterday, we reported details of RFdiffusion3, the next step towards building functional proteins straight from the computer.

Very excited to share our paper "De novo Design of All-atom Biomolecular Interactions with RFdiffusion3", now on BioRXiv. biorxiv.org/content/10.110… 1/n

La-Proteina open source now, excited to see what people build with it!

Thrilled to announce I'm starting as a Principal Investigator at #Aithyra in Vienna! We'll be developing generative models to understand cell biology and design proteins. I'm hiring PhDs, Postdocs, & Visiting Researchers! PhD applications by Sept 10: apply.cemm.at