Simak Ali

Can specific gene mutations drive CDK7 inhibitor resistance in #ProstateCancer? A brilliant team led by @simakali1 @imperialcollege share exciting new findings in @embojournal. Grab a ☕ and read: doi.org/10.1038/s44318…

Great way to finish the GRC Hormone-Dependent Cancers Conference by seeing our collaboration with the Wilbert Zwart lab published in PNAS. Glad to have contributed to this work. Read the paper here: pnas.org/doi/10.1073/pn…

So is the implication of this item that reviewers are uploading manuscripts into LLM? Does uploading manuscripts to LLMs by reviewers break confidentiality of the peer-review process? Scientists hide messages in papers to game AI peer review nature.com/articles/d4158…

Calling all friends in the North and fellow Yorkshirepersons: Join me at Kemps bookshop in Weatherby on the 24th. when I’ll be talking to design guru David Swann about Superveloce and much more lnkd.in/eYgbc4ar

I read this Cell paper that argues to have discovered a molecule (betaine) that mimics the geroprotective effects of exercise. This is a very valuable multi-omics resource, but the authors seemed to get caught in the rabbit hole of chasing a high-impact narrative🧵

Where were the editors for this book? Where was the proofreading by the publisher? The publisher is clearly also at fault here.

So enjoyed your last two books on the British car. Looking forward to reading the italian story.

I am delighted to share our new paper published in Molecular Cancer! molecular-cancer.biomedcentral.com/articles/10.11… As always, the credit goes to my great team and to all our collaborators! Interested in joining our lab: glare.bio #breastcancer #Immunotherapy #exosomes @SussexUni

If we want real progress we must protect those who speak out, not single them out goodlawproject.org/andy-george-ca…

The danger for the government is that it fails to control the things voters worry about - small boats and asylum hotels - while curbing the types of immigration that are popular and beneficial like scientists and care workers - my piece for @ObserverUK observer.co.uk/news/politics/…

We describe how to perform Oligo-seq, a new method to map DNA motifs targeted by base editors. Validated with APOBEC3A and APOBEC3B, but adaptable to AID, CRISPR-Cas9, and more. 🧬 Full protocol 👉 sciencedirect.com/science/articl… Thanks to @RemiBuisson @AmbrocioSanchz at @UCIrvine!

“Israeli forces have now dropped more explosives in Gaza than fell on London, Dresden, and Hamburg combined during the Second World War” says @NewYorker

Read our collaborative paper @longchrom, @molina_lab showing that disruption of NuA4 and ATAC coactivator complexes cause gene-specific transcript buffering, suggesting that cells dynamically adjust RNA export/degradation to sustain cellular homeostasis.10.1126/sciadv.adr1492

(1/n) The first preprint from our lab is now out in @NatureGenet! We tried to tackle a key challenge in spatial biology to quantitatively characterizing cellular niches by learning spatial gene programs using NicheCompas led by @SebastianBirk_. Paper: shorturl.at/b4Hjk

Our lab's very first manuscript is out in BioRxiv. Hope this would be interesting for many breast cancer scientists: biorxiv.org/content/10.110… @MCRCnews @MCRBreastCentre @LobularBCUK @FBMH_UoM

[1/2] Have a passion for cancer research? Want to understand how obesity drives lethal prostate cancer & grow your career at a world-leading University? 2x 3-year PhD studentships are available @imperialcollege, funded by @ProstateUK and PCF/ John Black Charitable Foundation.

The last 30 days has seen 2746 visitors to the Estrogene website (estrogeneii.web.app). Please keep spreading this free and user-friendly resource for interrogation and visualization of estrogen and anti-estrogen action in breast cancer #BCSM

Join the Virtual Cell Cycle Club virtual meeting on March 4, keynote Prof. David Pellman (Harvard) + short talks! 🔹 Free registration: events.abcam.com/cellcycleclub 🔹 Abstract deadline: Feb 14 (talks), Feb 21 (breakouts) www-eur.cvent.com/c/abstracts/24… #CellCycle #Science #CCCMeeting

🎥 Save The Prince Charles Cinema! This iconic London cinema is at risk of closing due to unfair rent demands. Sign the petition to protect its future #SaveThePCC you.38degrees.org.uk/petitions/save… via @38degrees

Congratulations to Dr Rayzel Fernandes on being awarded a Career Acceleration Award Fellowship! Rayzel is investigating the role of super-enhancers in therapy resistance. Read more about her exciting project taking place at @imperialcollege here: bit.ly/3vzjODl