Pedro Ortega

"La reparación de los cortes en el ADN está relacionada con el ritmo circadiano" Revista SEBBM 228 marzo 2026 por Amador Romero-Franco et al. @PabloHuertasLab @cabimer @unisevilla f.mtr.cool/oxcgnxgaof

RNA motifs can also be modified to recruit small molecules, proteins and RNA molecules in a sequence-specific manner to the RNA-rich phase @NatureNano @UCLA nature.com/articles/s4156…

Our paper is out! authors.elsevier.com/c/1mtQe3vVUPZN… We identified a role for BRCA2 in nascent strand maturation during DNA replication in the presence of PARP inhibitor.

🔥Our first paper on RNA localization is out! Led by talented postdoc Lusong Tian 🔥 LENG8 mediates RNA nuclear retention and degradation in eukaryotes: Molecular Cell cell.com/molecular-cell…

La US lidera en Andalucía la captación de fondos de la convocatoria Marie Sklodowska-Curie Postdoctoral Fellowships us.es/actualidad-de-…

Our most recent work on the “function and evolution” of #nuclear_speckles is now online at Cell @CellCellPress cell.com/cell/fulltext/… Read the thread 👇for the highlights of our findings.

Harvard scientists just shattered one of biology’s oldest rules. We were taught: Viruses can’t make their own proteins. They hijack yours. That’s why they’re “not alive.” Except giant DNA viruses just crossed that line. Researchers found they carry a full eukaryotic-style translation complex (vIF4F). Translation machinery. Inside a virus. They can keep making proteins even under stress that shuts down normal viral replication. If a virus brings its own protein-making tools… Is it still just a parasite? For decades we’ve drawn a clean boundary: Cell = alive Virus = not alive Nature doesn’t care about our categories. Maybe viruses aren’t just evolutionary side notes. Maybe they helped build complex life. Paper in Cell 👇 cell.com/cell/fulltext/… Harvard news: cellbio.hms.harvard.edu/recent-researc…

Happy to share the results from my PhD thesis, in which we uncovered a function for FANCD2 on maintaining fork stability upon re-replication, now out in Nat. Commun. 📖 Read the full story here:  nature.com/articles/s4146… Thanks to everyone who supported me along the way!

Now online! Hallmarks of cancer—Then and now, and beyond dlvr.it/TQjSM2

A study led by ERC grantee Mariano Barbacid @CNIOStopCancer shows that a three-drug combination can eliminate pancreatic cancer in mice by blocking the KRAS gene in multiple ways. bit.ly/4kckvYa

New online! Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity dlvr.it/TQDfqc

Great to see our latest study out in NAR Cancer: Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis academic.oup.com/narcancer/arti… @BrownUniversity @BrownUCancer @BrownPathology @EMGSUS

Flu infection flips a “PAR switch”: instead of hitting new targets, cells lengthen poly(ADP-ribose) (PAR) chains on the same proteins to slow the virus. Flu NS1 suppresses this; PARP1 drives it. ELTA revealed both site & length changes. nam02.safelinks.protection.outlook.com/?url=https%3A%…

Nature research paper: An RNA splicing system that excises DNA transposons from animal mRNAs go.nature.com/44SH1i4

Excited to see our research published!! 🎉 Amazing project in @FGH_Lab at @ibis_sevilla, @unisevilla "H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death" nature.com/articles/s4141…

Publication alert!🎉 First paper from our lab at @cabimer @unisevilla is out! We reveal that TOP2, a classic anti-cancer target, not only untangles DNA but also regulates gene expression through m6A RNA methylation. Thanks to our collaborators @magdamaslon and @lab_GonAguilera.

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! science.org/doi/10.1126/sc…

Fellow RNA enthusiasts: I'm organizing an RNA symposium on Jan 16, 2026 at @UCIrvine and attendance is free! A great opportunity to discuss the latest discoveries in RNA! Come join us! Contact me if you'd like to sponsor us.

New pre-print from our lab may be of interest to any replication stress/repair folks out there.. biorxiv.org/content/10.110…

Now out in @NatureComms, rdcu.be/eKaHC. Spearheaded by @jordancjwilson with Marciniak Lab @TheCIMR, @villunger, @ERC_Research partners @jcornlab & @LoizouJoanna & colleagues @BiffiGiulia @CRUK_CI, this work sheds light on WEE1 inhibitors and their therapeutic use.