Siren Biotechnology, Inc.

On the heels of IND clearance for SRN-101, we are thrilled to announce another major milestone at @SirenBio! 🚀 The FDA has granted #FastTrack Designation to SRN-101, our lead Universal #AAV Immuno-Gene Therapy candidate for recurrent high-grade glioma 🧠 Fast Track status reinforces the urgency and potential impact of bringing this first-of-its-kind therapy to patients. Momentum is building and we’re just getting started! 💥

The @SirenBio team is heading to Phacilitate #ATW26 next week. Our Founder & CEO, @Nicole_Paulk, and our SVP of Vector Development Nathalie Clement look forward to meeting with partners, peers, and fellow leaders pushing the field forward. If you’ll be in San Diego, we’d love to see you!

A big day of celebration here at @SirenBio! 🎉 We’re thrilled to share that the FDA has cleared our first IND for SRN-101, enabling our Phase I/II trial of what we believe is the first #AAV #GeneTherapy for any #cancer clinically. This milestone marks a major step forward in bringing SRN-101 to patients with recurrent high-grade glioma. Huge congratulations to our incredible team, advisors, and partners who helped make this moment possible!

It’s a busy start to 2026 at @SirenBio! We’re excited to be out in full force at #JPM2026, #ATW2026, and #BiocomGPIC. Come meet with us at: 📍 JPM Jan 12-15 | San Francisco, CA 📍 Advanced Therapies Feb 9-12 | San Diego, CA 📍 Biocom Feb 24-26 | La Jolla, CA If you’ll be there too, let’s connect!

@ASGCTherapy We hope folks enjoy this! #GeneTherapy

Dr. Niki Paulk, CEO and Founder of @SirenBio joins the podcast for a timely conversation on turning scientific promise into commercial success. 🎧 Listen now: asgct.org/education-care…

Happy holidays from the @SirenBio team!🎄Our key moments were submitting our first IND to the FDA (today!) and closing our first-ever community investment round. But these can’t overshadow all the other accomplishments our team had in 2025. In all, we counted: ⚡ 8 new cancer indications tested 💸 1,529 new investors ✍️ First IND filed 🧠 3 new SAB members 🧪 10 formal assay qualifications 🏅 3 big awards received 🧬 100+ new constructs screened 💪 1 cancer diagnosis AND recovery! 💼 7 conferences attended 🐣 1 new baby 📆 50 weekly syncs and 26 lab meetings 🥹 1 proud team with ♾️ accomplishments…make that ♾️ + 1! 💛 Stay tuned for our 2026 tally…

🚀 Hey #founders and builders! Thinking about opening your own community investment round? We just dropped the full recording of our webinar where the @SirenBio team walks through how we approached - and successfully ran - our own community round. It’s not legal or financial advice, just an honest look at what worked for us (and what we learned along the way). If you’re a founder curious about bringing your supporters in as investors, this is a great place to start. Featuring: @Nicole_Paulk and Akela Kuwahara from @SirenBio Nina Ekmescic from Capital Department Jonny Price from @Wefunder 🎥 Watch the full video here: youtu.be/kn4gEIIS_sc #StartupFunding #CommunityRound #BiotechStartups #Founders

@FrankJWoods2 $4.2 million 😎

@SirenBio Did you hit 4mil in Community Round?

Final Call: @SirenBio's Community Round Is Closing Soon! 🚨 When we opened this raise, we set out to do something bold – not just in the lab, but in how we build this company. We invited you, our community, to help shape the future of #cancer care. And the response? Absolutely incredible. Since launching this round, we’ve hit major milestones: 💸 $3M+ raised 👥 1,250+ investors have joined the mission 🏆 Named Start-Up of the Year at Advanced Therapies Week 🎤 Took the stage at SXSW to spotlight our universal gene therapy 🎖️ First patent granted protecting core tech behind SRN-101 🐖 Large-animal studies launched to advance toward human trials 🧬 Successful Pre-IND meeting with the FDA, keeping us on track for the clinic in 2026 👩‍🔬 GMP production of SRN-101 is officially underway Our community round is closing in *just a few weeks*. If you’ve been thinking about investing (or upping your stake), now is your chance. Invest or increase your investment today: lnkd.in/gNdrgNck Here’s to a strong close!! 🚀

Curious what it was like to launch one of the first ever biotech community investment rounds? We're hosting a webinar for founders and builders next week! RSVP here: luma.com/w1j7jtrv

Wow — what a way to close out our first-ever community round! 🎉 We’re incredibly grateful to the 1,600+ investors who joined our mission and helped us raise over $4.2 million to support the next generation of cancer gene therapy. This round wasn’t just about funding. It was about opening the doors to patients, families, advocates, doctors and anyone who believes cancer care has to be faster, smarter, and more effective. We’re honored to have you with us on this journey. 📝Check out our final campaign update on Wefunder: wefunder.com/siren.biotechn… Here’s to an exciting chapter ahead!

Only a few hours left, and that’s it! ⏳ The momentum in these final hours has been incredible. We’re closing in on $4M raised from over 1,500 investors, and we couldn’t be more proud of what this community has built. Here’s why investors are excited about Siren: 🧬Universal AAV gene therapy for cancer 💸$28M raised from top-tier VCs including Founders Fund and Lux Capital 🏆Named 2025 Start-Up of the Year at Phacilitate Advanced Therapies Week 🔬550+ animals treated with curative preclinical data 🧪Clinical trials targeted for 2026 🎓Team from Stanford, UCSF, Duke, Mount Sinai, and Roche 🎖️First patent family awarded 👑Called “perhaps the most de-risked pharma startup” by Kingscrowd 🌍Tackling a $3.2B+ global market for brain tumor therapeutics 🎙️Featured at SXSW 2025 We opened this round to give more people a seat at the table in building the future of cancer care and we’ve been blown away by your belief, support, and boldness. ❤️ 🚨Join us or increase your stake before our round closes for good → wefunder.com/sirenbiotechno…

@woodien @harmonybabyfood Woot woot 🎉 Wefunder.com/siren.biotechn…

The line between VC and the crowd is officially blurring. Today's Crowd Favorites report features companies backed by top-tier funds. Big congrats to @harmonybabyfood and great to see @SirenBio back on the list before their round closes.

🚨We’re almost at the finish line – Siren’s community investment round closes TONIGHT This is your final chance to invest in the company developing a universal AAV immuno-gene therapy for cancer. 💸 $28M raised from top VCs including Founders Fund, Lux Capital & more 🧬 $3.8M+ raised from 1,500+ community investors (and counting!) 🏆 2025 Start-Up of the Year at Phacilitate Advanced Therapies Week 🧠 Game-changing universal AAV gene therapy 🔬 550+ animals treated with curative preclinical data 🧪 Targeting clinical trials in 2026, a critical step toward FDA approval 🎓 Powerhouse team from Stanford, UCSF, Duke, Mount Sinai, and Roche 🌍 $3.2B global market for brain tumor therapeutics Let’s bring a radically new kind of cancer treatment into the world. 🎯Invest or increase your investment before 11:59pm EST: 👉wefunder.com/sirenbiotechno… Here we go!

We just wrapped our Virtual Closing Celebration and we’re still feeling the energy and deep gratitude from this incredible community. 🥂 1,450+ #investors have already joined our mission to change the future of #cancer care and we can’t keep count fast enough! If you missed the event, the replay is now live: 🎥Watch the replay → youtube.com/watch?v=QWJUEq… 📅Book a call with our Founder & CEO → calendly.com/npaulk/15-min-… Our community round closes in just a few days, and we don’t plan to open another. If you’ve been thinking about investing, increasing your stake, or sharing this with someone who should be part of it, act now. This has been one of the most meaningful chapters in Siren Biotechnology's journey. Let’s finish strong! 🚀 🔗 Invest now at wefunder.com/sirenbiotechno….

Join the @SirenBio team for our final community investor webinar TODAY! 🗓 Wednesday, October 15 🕚 11:30am PT / 2:30pm ET 🎟️ RSVP here: luma.com/dlyq5t6j Can't make the webinar but still want to chat about investing before the round closes this week? Book a time to speak with our Founder and CEO, @Nicole_Paulk here! calendly.com/npaulk/15-min-…

A look behind the scenes at the incredible journey of our Founder and CEO, @Nicole_Paulk, whose personal experience with cancer has fueled @SirenBio's relentless pursuit of transformative cancer therapies.

@woodien @WindHarvester Thanks for the shout out 👋 Folks can check us out at: wefunder.com/siren.biotechn…

Yesterday's holiday kept investment numbers low, but look at where the money went. We're seeing crowds back complex solutions in green energy and healthcare. These are real, world-changing efforts. Shout out to @WindHarvester and @SirenBio for capturing the crowd's attention!

It’s closing week! Our community investment round officially closes this week. 🚨 If you’ve been thinking about investing, increasing your investment, or sending it to someone who should be part of this mission - this is the time. Check it out here: wefunder.com/siren.biotechn… Don’t forget, we’re marking the close with a special Virtual Closing Celebration + Live Q&A this Wednesday, October 15th at 11:30am PT / 2:30PM ET. RSVP: luma.com/dlyq5t6j 📞 Curious about investing but want to speak with us first? Book a 1:1 investor call with our Founder and CEO @Nicole_Paulk this week. If you’ve got questions, want to talk science, or what’s ahead - we’d love to connect. Book a time → calendly.com/npaulk/15-min-… Let’s close this chapter strong! 💫

Our community round is closing next week, and you’re invited to the final celebration! 🚨 Over the past few months, 1,300+ investors have joined @SirenBio's mission to change what’s possible in cancer treatment. You’ve believed in the science, the vision, and the power of community. From our entire team: thank you ❤️ To mark this milestone, we’re hosting a Virtual Closing Celebration + Live Q&A next week: 🗓 Wednesday, October 15 🕚 11:30am PT / 2:30pm ET 🎟️ RSVP here: luma.com/dlyq5t6j We’ll answer your final questions, share what’s next for Siren, and connect with anyone still thinking about joining before the round officially ends. 💡 This is it. We don’t plan to open another community round - so if you or someone you know believes in a better future for cancer care, now’s the time to get in. Please share this invite with them! Here’s to a strong close and to building the future of cancer treatment, together. 💫 Invest now at wefunder.com/sirenbiotechno…

Catch @SirenBio's CEO and Founder @Nicole_Paulk on the Smart Humans Podcast by @DiscoverVincent! Listen to the full episode here: withvincent.com/research/smart…