The Snedeker Lab

Out today in Nature Communications: @Amro_Hussien shows that tendon fibrosis in systemic sclerosis is mechanically gated. We link elevated matrix tension to myofibroblast activation, suppressed collagen transcription, and rewired stromal–immune crosstalk. nature.com/articles/s4146…

Submolecular modulation of PIEZO1 mechanotransduction with wireless ta... sciencedirect.com/science/articl… ☝️💪

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine science.org/doi/10.1126/sc… Important work with @KatrienDeBock, driven by @MoschiniGreta. @snsf_ch | @derbalgrist | @UZH_en

This model approaches tissue-level thresholds (~3 %) seen in explants (Passini et al., Nat BME 2021). #tendon #mechanobiology #ECM #cellmatrix #ActaBiomaterialia

Blocking cross-linking with BAPN stalls adaptation (~15 %). In ECM-poor (ascorbate-free) sheets, cells adhere well yet no Ca²⁺ response even > 20 % strain.

Excited to share one of our lab’s most important papers in Acta Biomaterialia! (Patrick Jaeger, lead author). We present a 2D/3D tendon-sheet model of wound healing showing how ECM maturation and cross-linking tune tendon cell strain sensitivity. 🔗 doi.org/10.1016/j.actb…

🚀 Big News! Our comprehensive review on Achilles Tendinopathy is out in Nature Reviews Disease Primers! 📖💡 🦵 Dive into the latest on pathophysiology, diagnosis & treatment. Huge thanks to our CostAction for supporting collaboration! 🔗 Read here: lnkd.in/dd2_M6rG

FiberLock technology achieves the long-standing challenge of bearing physiological disc loads without re-herniation. Congrats to the lead author Esteban Ongini & thanks to Sarah Gullbrand @MauckLabfor the amazing collaboration. DOI: doi.org/10.1002/jsp2.7…

Excited to share our latest publication in @eLife: doi.org/10.7554/eLife.… Our study uncovers how IL-6/JAK/STAT signaling contributes to tendinopathy by activating fibroblasts. Kudos to Tino Stauber & the team!

We are looking for an enthusiastic Research Software Engineer for a fixed-term position. Your contribution will be fundamental to advance the impact of open-source software for musculoskeletal image analysis! Contact me! Please, repost! #researchsoftwareengineer #opensource

Thanks Tino (and @MWolleb) for the detailed map on how to use tendon assembloids to unlock secrets of cellular crosstalk across tissue compartments....

Thanks to the @ors_tendon section (and @awad_lab for the photo). And a huge congratulations to the winners, including our own Maja Wolleb. Nice!

Congratulations to Prof. Mazda Farshad for winning the Unified Experiences Trailblazer Award from #Cisco! We are delighted to receive the award and to be included in the Cisco Country Digital Acceleration Program with our @OperatingRoomX @CiscoInsider cisco.com/c/en/us/about/…

@SheynLab @Julia_Sheyn @jboerckel @WensenJiang @WafaTawackoli @GiselleKaneda @TYuanzhang @GawriLab What a great table. Thanks Dima for the fantastic meal!

Traditional Sheyn lab and friends dinner at the #ORS2024

Excited to be organizing this Session at the TERMIS World Meeting in Seattle with Nathaniel Dyment and having Jess Snedeker as invited speaker! Submit your abstract, deadline is approaching soon! @TERMISAM @DymentLabPenn @SnedekerLab

The Department of Health Sciences and Technology @ETH_en is recruiting an Assistant Professor (Tenure Track) of Musculoskeletal Bioengineering. More information at ethz.ch/en/the-eth-zur… Please repost !

One step closer in understanding how tendon mechanotransduction drives functional tendon adaptation and increases human performance. #Tendon #Mechanobiology #Genetics #Performance

Congratulations to Tobias Götschi and friends - a newly published human study directly linking PIEZO1 gain of function to increased patellar tendon stiffness: doi.org/10.1152/japplp…

A tour de force of the enthesis and tendinopathy with basic science and clinical insights. Thanks to @TheLancetRheum team for all the help …. @UofGMVLS @UofGSii @UofGlasgow ….from me personally a huge thanks 🙏 to the team … fantastic work 🎉👏👏👏