Soldati Lab

🚨New paper from the lab!🚨 As everyone, Toxoplasma needs to feed its daughter cell for their proper development 🫕🍔 Here, we describe the first transporter that regulates lipid homeostasis of the daughter cell alveoli. @SanchezSyrian Find more here 👇 journals.plos.org/plospathogens/…

🚨New paper from the lab! 🚨 What happens during PCR biogenesis? Why is there a non-functional myosin in the PCRs? 🔬🔎 This and much more in the bioRxiv preprint 👇 biorxiv.org/content/10.648…

New paper from the lab! Great collaborative work to show the tethering of the conoid 🔬🧫 Congrats to all the authors involved! 🎉 journals.plos.org/plosbiology/ar…

This parasite can be continuously cultured, offering a valuable tool for apicoplast research and drug discovery! 💊🔬 Congrats to all the authors involved for this amazing piece of work! 👏🎉

🚨New paper out! 🚨 The apicoplast is an essential plastid retaining many crucial metabolic pathways 🦠🏭 However, bypassing all of them makes the apicoplast dispensable! nature.com/articles/s4146…

Excited to see our paper published in MBOC! 🎉 Our research explores a glyoxalase-like protein in the apicoplast, crucial for Toxoplasma growth and organelle homeostasis maintenance. Huge thanks to the newly promoted Research Director @s_besteiro🏋‍♂️ doi.org/10.1091/mbc.E2…

Our structure-function analysis of the #Toxoplasma #mitoribosome reveals a novel role for poly A tails and repurposed protein domains in mending tens of rRNA pieces into a functioning ribosome nature.com/articles/s4146… @BIOTECH_UH @wellcometrust @UofGSii @UofGMVLS @shikha_tweets

It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-fragmented mitoribosome from Apicomplexa, such as Plasmodium falciparum and Toxoplasma gondii, now out in @NatureComms rdcu.be/d3R8C

Last but not least, big congrats to @Hashemyaser4 @OscarVadas and all the others authors involved! 👏🎉🐈‍⬛

These findings highlight a novel adaptation shared between the Alveolata, by which transcription factors evolved into RNA-binding proteins. Targeting this unique mitoribosome assembly machinery could open new possibilities to treat diseases such as malaria and toxoplasmosis. 🦠💊

Mitochondria are the powerhouse of the cell, producing essential energy for life 🏭⚙️. To synthesize the proteins for this process, mitochondria have mitoribosomes. But, how do the mitoribosomes from Alveolates assemble? 🧵 nature.com/articles/s4146…

Christmas is coming ☃️, and in Switzerland this means... fondue! 🫕 Enjoying tons of cheese with #Brochetlab and @AmandineGuerin5 lab 🧀❄️🔬

How does #Toxoplasma gondii move? @unige_en scientists reveal apical polar ring & conoid as key players controlling actin flow, crucial for motility & invasion Full bit.ly/4i33Tk3 Summary bit.ly/4i9Zg7V By @Romzouz1 & Bingjian Ren @SoldatiLabToxo @MIMOL_UNIGE

Thanks to the wonderful collaboration with @yiweichang 🤝 and congratulations to @Bingjian_Ren, @Romzouz1 and all the authors involved! 🔬❄️🎉

In this article, a repertoire of apical polar ring proteins was studied and assigned to the different APR layers. Among them, APR2 contributed to parasite's motility and invasion and its depletion caused destabilisation of the APR middle layer and F-actin leakage to the cytosol.

🚨 New publication out: Architecture of the Toxoplasma gondii apical polar ring and its role in gliding motility and invasion 🧫🐈‍⬛ Read more pnas.org/doi/10.1073/pn…

Congrats to @SanchezSyrian and all the authors involved in the paper describing a novel protein involved in apicoplast homeostasis and parasite growth! 👏🦠🐈‍⬛ biorxiv.org/content/10.110…

RNG2 tethers the conoid to the apical polar ring in Toxoplasma gondii: a key mechanism in parasite motility and invasion dlvr.it/TCY679