Soslowsky Lab
246 posts
@SoslowskyLab
Tendon-enthusiasts! Putting the FUN in structure-FUNction! (Student-run account... in case it was not painfully obvious)
Register now for an @ors_tendon #WebinarWednesday on Sept 24, 12 PM CST, A Tendon-cy to Heal: Regenerating Tendons & Ligaments in Zebrafish. Hear from Thomas Schilling, Jenna Galloway & Joanna Smeeton on the latest #tendon & ligament regeneration. 🔗ors.memberclicks.net/ten092425web#/
Register now for an @ors_tendon #WebinarWednesday on Sept 24, 12 PM CST, A Tendon-cy to Heal: Regenerating Tendons & Ligaments in Zebrafish. Hear from Thomas Schilling, Jenna Galloway & Joanna Smeeton on the latest #tendon & ligament regeneration. 🔗ors.memberclicks.net/ten092425web#/
🦴 Does lactation strengthen or weaken the skeleton? Check out this @ORSsociety Basic Science Tip to learn how elevated PTHrP shrinks both bone & marrow fat, while PTH1R signalling worsens bone loss, revealing new hormonal control of maternal bone health. #943d914a4ffa32f03" target="_blank" rel="nofollow noopener">ors.org/basic-science-…
A serious injury to aging tendons often means a slower, less complete recovery – one that science is still trying to fully understand. Researchers used a preclinical model of aging to investigate how two key proteins, decorin and biglycan, influence tendon healing. Using a controlled knockdown approach, they assessed structural, genetic, and mechanical outcomes across early and late healing stages. They found: 🔹 When removed early, decorin knockdown appeared to improve recovery of viscoelastic properties. 🔹 Biglycan deficiency delayed initial healing but didn’t impair final mechanical strength. 🔹 Collagen fibril architecture changed, yet quasi-static strength measures were unaffected. These findings suggest subtle, protein-level interventions may help aged tendons heal smarter, not just stronger. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10.100… 𝗦𝘁𝘂𝗱𝘆: Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May Not 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Christelle Darrieutort-Laffite, Stephanie N. Weiss, Courtney A. Nuss, Joseph B. Newton, Jeremy D. Eekhoff, and Louis J. Soslowsky @Penn @PennMedicine @McKayLaboratory @PennEngineers @pennbioeng @SoslowskyLab @CHUnantes @Inserm 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10439
Your pipetting setup = your personality. Share a photo of your pipette station, tip boxes, and/or how you organize your bench!
The @SoslowskyLab are at it again, showing that 16 weeks high-speed running does not induce #Achilles #tendinopathy in rats. Do rats have better post-exercise recovery than humans. Can we learn anything from that to improve human tendon recovery? journals.physiology.org/doi/abs/10.115…
@JOrthopRes Patients w/ Ehlers-Danlos Syndrome (cEDS) present w/ extensible skin & joint instability, with more females affected. In a mouse model of cEDS, Vet-Scientist @jaclynacarlson discovered altered healing in this population. Link: buff.ly/crnkIwN #ORSSMC #ORSxDerby
