Stanford RNA Medicine Program

New in @Nature: Schiffers et al. establish ac4C as a high-fidelity alternative to m1Ψ for mRNA therapeutics. By doubling translation elongation speeds and bypassing ribosome collisions, ac4C modification ensures superior protein yield and accuracy. #mRNA nature.com/articles/s4158…

What is the future of #CRISPR and AI in medicine? Stanford RNA Medicine Symposium Keynote Speaker Dr. Jennifer Doudna joins @emilychangtv on Bloomberg Originals to discuss the next frontier of biotech. Watch: youtube.com/watch?v=n-hWHV…

Nature Communications: Research reveals how extracellular vesicles distort LNP protein corona profiles. Precision depletion is essential to identify genuine interactomes like ApoE for targeted mRNA delivery. #LNP #DrugDelivery nature.com/articles/s4146…

New research in @Nature shows mRNA vaccine CD8+ priming bypasses cDC1 cross-presentation. Non-hematopoietic cells act as primary transfectants; cDC2s acquire pMHC-I via IFN-I-dependent cross-dressing to drive robust CTL responses. #mRNA #Immunology #Sec5" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…

New Phase 3 systems serology in Nature npj Vaccines: ARCT-154 (5 µg) sa-mRNA maintains superior neutralization & NK activation through Day 394 vs conventional mRNA. Prolonged antigen expression drives enhanced immune durability. #mRNA #Vaccinology nature.com/articles/s4154…

New in @Nature Nanotechnology: Researchers used metal-ion-assisted RNA folding (MARF) to stabilize mRNA. Rigid architectures improved intracellular processing and boosted protein production 7.3-fold. #Nanotechnology #mRNA nature.com/articles/s4156…

Phase I study in @Nature: individualized mRNA vaccines for early-stage TNBC, given with standard therapy, elicit durable CD4+/CD8+ T cell responses with persistent clonotypes. Early clinical signals show encouraging multi-year relapse-free outcomes. #RNA nature.com/articles/s4158…

Segmented polyA tail design improves both template DNA stability and protein output from in vitro transcribed mRNA, per a recent Nucleic Acids Research study. #biotech #RNAresearch academic.oup.com/nar/article/54…

"SOS splicing," reported in Nature, is a pathway in C. elegans and human cells that recognizes inverted terminal repeats and excises DNA transposons from mRNAs—buffering genes from TE insertions. #RNA #Transposons nature.com/articles/s4158…

Why does loss of ADAR1 editing trigger immune activation? @StanfordMed researchers identify a small, structural subset of endogenous dsRNAs that drive MDA5-mediated interferon signaling, refining understanding of #RNA sensing in autoimmunity. nature.com/articles/s4158…