STEM CELLS Translational Medicine

Perspective on the efficiency of carcinogenesis and the potential of dynamic precision medicine to prolong survival and increase cure rate. doi.org/10.1093/stcltm…

Commonly used study designs for hiPSC-based disease modeling, drug response, or cardiac toxicity are compared in terms of applicability for different research questions, statistical analysis, and attainable power. doi.org/10.1093/stcltm…

Cell therapy for stroke and spinal cord injury in clinical trials doi.org/10.1093/stcltm…

This review discusses the mechanisms and therapeutic applications of epicardial activation, emphasizing its potential in cardiac regenerative medicine. doi.org/10.1093/stcltm…

Meta-analysis evaluating the efficacy and mechanisms of stem cell therapy in rodent models of hepatic ischemia-reperfusion injury doi.org/10.1093/stcltm…

A challenge in regenerative medicine is finding ways to restore the body’s natural capacity for repair. This study reports on a powerful molecular tool, the miR-302/367 cluster, which plays an important role in reversing signs of aging. doi.org/10.1093/stcltm…

This review discusses cellular senescence and functional tissue decline, focusing on small molecule-driven reprogramming as a tool to rejuvenate aged cells and tissues. doi.org/10.1093/stcltm…

This concise review discusses the most recent scientific progress in the field of human iPSC-derived neural stem/progenitor cell therapy for spinal cord injury. doi.org/10.1093/stcltm…

Modeling rare genetic disease with gene-edited induced pluripotent stem cells: relevance of the starting stock line doi.org/10.1093/stcltm…

Phase II randomized controlled clinical trial comparing IV & IT routes of allogeneic umbilical cord-derived MSC infusions for stroke recovery. doi.org/10.1093/stcltm…

This brief report describes a novel inverse relationship between circulating leukemic stem cells and BCR::ABL1 transcript carried by extracellular vesicles in chronic myeloid leukemia. doi.org/10.1093/stcltm…

Unlocking extracellular mitochondria from bench to clinical application in stroke doi.org/10.1093/stcltm…

Read about recent advancements in protocols related to tissue dissociation in the context of cell analysis and downstream processing: doi.org/10.1093/stcltm…

Predicting metabolic dysfunction–associated steatotic liver disease risk using patient-derived induced pluripotent stem cells doi.org/10.1093/stcltm…

Acute-on-chronic liver failure (ACLF) is characterized by severe systemic inflammatory response and organ failure. This study investigated whether MSC-Exos could alleviate the inflammatory response associated with ACLF. doi.org/10.1093/stcltm…

This study focuses on the anti-fibrotic property of human amniotic fluid stem cells in mitigating the biliary epithelial- mesenchymal transition process. doi.org/10.1093/stcltm…

This study focused on chronic limb threatening ischemia (CLTI), a severe form of peripheral artery disease, and endothelial colony forming cells (the true endothelial progenitor cell) as potential therapy to treat CLTI. doi.org/10.1093/stcltm…

Two questions are addressed in this study: first, if undifferentiated iPSCs injected into an injured joint can regulate cartilage regeneration, and second, if iCasp9 would reduce the risk of tumor formation post-transplantation of iPSCs. doi.org/10.1093/stcltm…

This article highlights a promising new direction using extracellular vesicles released by mesenchymal stromal cells, which can help reduce inflammation, promote regeneration, and support the development of immature organs. doi.org/10.1093/stcltm…

This study has established a platform for advancing cardiovascular tissue engineering applications. doi.org/10.1093/stcltm…