Carrie Radomski

Imagine dying right before longevity escape velocity. We gotta freeze people today so they can make into the future.

@LuminaProbiotic I put the genetically modified bacteria onto my teeth last night.

The primary purposes of cryopreserving the human body are threefold: 1. For conditions that are currently incurable, such as terminal illnesses or severe injuries (in an era of immortality, the main causes of death would be accidents like traffic collisions, making cryonics a lifesaving solution for such incidents), individuals can be cryopreserved until technology advances enough to treat them. They can then be thawed, revived, and cured. 2. For aging, which currently cannot be reversed, individuals can be cryopreserved until technology develops the capability for rejuvenation. They can then be thawed, revived, and restored to youth. 3. Astronauts can suspend their lives, undergo journeys lasting thousands of years, and be thawed upon reaching their destination planets to begin cosmic colonization and exploration. The larger the body mass, the greater the difficulty of freezing and thawing. Currently, cryopreservation and thawing technologies are fundamentally incapable of reviving a human body weighing several tens of kilograms. Even a mouse weighing just over 10 grams cannot be revived. Therefore, cryonics technology requires a disruptive innovation. Both the cooling process during freezing and the warming process during thawing produce ice crystals. These ice crystals can puncture cell membranes and damage internal cellular structures, which is the cause of biological death. Thus, how to inhibit the formation of ice crystals during cooling and warming is a critical issue determining whether cryopreserved individuals can be revived. Some have proposed using nanomachines to repair cellular damage, but this is not feasible. The repair process requires identifying the location and type of damage, which demands sufficient intelligence. However, nanomachines are too small to accommodate microcircuits. Additionally, nanomachines cannot move through dense tissues and cells filled with proteins and other substances. As for the ice crystals formed during freezing and thawing, which may damage some of the synaptic connections in neurons related to memory, could this lead to memory loss? I believe that brain memory is holographic. Every day, some neurons in our brain die while new ones are generated, and synaptic connections are deleted and regenerated. Yet, memories are not entirely erased; only unimportant memories become increasingly vague. This is similar to a holographic photograph: tearing it into pieces does not make the entire image disappear. However, the smaller the fragments, the blurrier the image becomes. Therefore, the destruction of a small portion of neurons and synaptic connections by ice crystals during freezing and thawing would not result in the loss of existing memories. As for whether to preserve the entire human body or just the head, I believe preserving the entire body is best. For those who only preserve the head, during future thawing and revival, the head would need to be transplanted onto a body cloned from the head's own cells. However, we cannot guarantee that a body cloned from one's own cells would be entirely free of immune rejection. During the process of cell division and cloning, DNA mutations occur. The immune system can trigger rejection even with the slightest mutation. Evidence for this includes: 1. The 30th amino acid in the B chain of human insulin is threonine, while in pig insulin, it is alanine. This single amino acid difference can lead to the production of antibodies and rejection when humans use pig insulin over the long term. 2. An article published in *Nature* on May 13, 2011, titled "Immunogenicity of induced pluripotent stem cells" reported that researchers from the University of California, San Diego, transplanted adult cells differentiated from reprogrammed mouse somatic cells (iPS cells) back into the source mice. Although the genetic background was identical, the mice rapidly rejected the transplanted cells. 3. Currently, transplantation of adult cells differentiated from iPS cells is limited to immune-privileged organs, such as the eyes, primarily because the immune system rejects the grafts as foreign in non-immune-privileged organs. Hibernation involves lowering body temperature and metabolic rate to enter a prolonged sleep. Hibernation requires the coordinated expression of many genes. Humans may possess genes related to hibernation. However, due to the principle of "use it or lose it" and millions of years of natural selection, the hibernation gene cluster in humans has likely mutated and degenerated. Therefore, achieving human hibernation is highly unlikely. To survive hot and dry environments, some animals enter aestivation. During aestivation, body temperature may not necessarily decrease, but the metabolic rate still drops. While human hibernation is currently unattainable, future approaches may use gene editing or plasmid transfection technologies to enable human cells to produce hibernation-related substances, thereby achieving human hibernation. Dormancy is a process in which plants and animals completely halt their metabolism. Some species of moss can remain dried for centuries and revive immediately upon contact with water. However, the human body cannot be preserved through desiccation because drying causes the brain to shrink and disrupts its three-dimensional structure. Many microorganisms and spores possess the ability to enter dormancy. The fairy shrimp (Artemia) cannot be killed by boiling or freezing, and its eggs can survive desiccation for hundreds of years. The resurrection plant (Selaginella lepidophylla) is also resistant to drying, freezing, and boiling. In the summer of 1983, I cooked mung bean soup in a thermos flask at 80–90°C for half a day. While most of the mung beans softened, a few remained hard and were called "iron mung beans" or "mung bean ghosts." I washed these uncooked beans and placed them in a warm, humid environment, rinsing them with clean water daily. After a few days, they swelled and sprouted white buds. Although they eventually rotted, the emergence of white buds indicated that they retained some vitality. If cooling occurs at a very rapid rate, ice crystals do not form, resulting in a state known as vitreous ice. However, the human body is too large. While the exterior can be cooled rapidly, the interior cannot achieve the same speed. The same applies to the warming process.

"Nothing in life is certain except death, taxes and the second law of thermodynamics. All three are processes in which useful or accessible forms of some quantity, such as energy or money, are transformed into useless, inaccessible forms of the same quantity. That is not to say that these three processes don't have fringe benefits: taxes pay for roads and schools; the second law of thermodynamics drives cars, computers and metabolism; and death, at the very least, opens up tenured faculty positions." -Seth Lloyd, writing in Nature 430, 971 Reading Wikipedia is always good/fun. When I was a child I thought everything was fine but then I grew up and found out that people simply accepted death and taxes and then I realized it wasn't fine.

@AustinTLynch @cryopets Cryopets first patient! Very "Cool"

Today I held my best friend of 13 years as he passed. He didn't want to go. This is why @cryopets matters. In my line of work I've known many who were on the brink of death from cancer or other illness. None of them fought and screamed like he did. Humans have the ability to rationalize and create peace with death. Animals don't get that luxury. They don't think they'll no longer suffer because they'll be in heaven or they'll reincarnate as something new. They know they have one life and they need to keep it. Give them the chance to do so, and take that chance for yourself when the time comes. He was the smartest of any dog I've personally known, capable of using audio cues like buttons and bells to exert his will upon the world. Bone cancer took his ability to walk and he never stopped trying. At 3 he broke his knee and tore the ACL in his other leg and from that he recovered. At 13 cancer ate away at his shoulder completely and struck rapidly, but even until his last day today he fought through it, clawing and screaming his way through, knowing if he gave up he would die. It's his time to rest now. He fought as hard as he could but cancer is a demon we've yet to slay. Now he'll wait for the day we've got the cure to cancer, aging, and death itself. Someday I'll be there right beside him. Hopefully with my work I can make that day sooner for him to enjoy the snow again.

Robert Munsch, famous children's story author has been approved for medically assisted dying (MAID). Both my children and I have been moved by his work. Some of my earliest memories have been of the experience of his funny, imaginative stories. His books have touched the hearts of millions of children and parents around the world. He chose MAID over 5 years ago when he was diagnosed with dementia and is now losing more of his faculties each year. Many people seem to be critical of his personal decision. I don't blame him for his decision; dementia is a terrible disease that slowly strips away a person. I have a wish he would choose cryonics. There are so many people who could potentially benefit the future of humanity if their minds were archived. We don’t just want computer scientists, rich people or mathematical prodigies to be preserved, we want people from all walks of life. Many people think cryonics is a selfish decision (so that one might live) but I think if Robert Munsch could live again that would be great for everyone.

@JimDMiller This sounds like a hilarious prank rather than an experiment.

Unethical consciousness experiment: Convince smart college students that MRI scans just revealed the “seed of consciousness” and that only 95% of people have it. Then get class scanned and tell some students their results show they lack consciousness and test if they believe it.

@cryodao @kaimicahmills Not today grim reaper!

How it feels to hold $CRYO. 🧊

People are changing their PFP to Clippy for "social activism" and I can't stop thinking about how paperclip maximization has already started.

GPT-5 does not allow us to estimate our chronological age anymore from pics. It used to be pretty accurate. Even more so than some epigenetic tests. Disappointing they had to lobotomize it to be more PC, I thought we were past this. *update* my friend messaged me and said it estimated his age and he's a caucasian male. GPT-5 told me it couldn't tell me ethnicity or age at all and I inputted my image as an Asian woman. TF is going on haha I had been calculating my phenotype age, my epigenetic age and my GPT estimated age and comparing the robustness of each reading.

With high subzero experiments how translatable are the results to low subzero as we have with cryonics patients? Which classes of cryoprotectant used in low subzero cryoprotectant can be used in high cryoprotectants as low concentration may not work at all? It seems like with high subzero we can use cryoprotectants that just depress freezing point rather than using the type for low subzero.

"Your OMICm age is a deeper reflection of your biological age, considering the effects of lifestyle, environment, and genetics on your DNA and the aging process. DISCLAIMER: The percentile for OMICm Age is based on observed and validated data patterns from an equal distribution of Harvard research participants and TruDiagnostic clients to emulate a population of average health." Why do my results vary so much? My "biological age" should not be jumping around 5 years from month to month. I'm beginning to think LLMs are actually more robust at predicting biological age.

🧵1/ LBF7 Spain is happening and we're doing something kinda wild: -We’re gathering the smartest people who want to SOLVE AGING -going to a longevity resort in the Spanish mountains -to learn, discuss and ACTUALLY BUILD stuff for 7 days straight Here’s what we’re cooking 👇

@BigTechAlert @sama @yacineMTB Is Sama trying to build another X?

🆕 @sama has started following @yacinemtb

@octal Booo

What fucking taxi cartel revanchist sodomized uber at JFK T4? Now there is a bus?

@yacineMTB Idk some people just seem cursed.

I wrote a blog post about this. Probably one of my best blog posts you can 100% make your luck. most people who are "lucky" just have a set of behaviors that creates luck Link below if you're subscribed

Kinda wild but I knew @hollowearthterf online before she was on X. I started following RFH because of her hilarious tweets and then with the Hanania face reveal I was like WOW, wtf I used to know her. Backstory, she's never been a pickme or thot, so legit. I'm a nobody on here but yeah. It's such a weird coincidence or maybe not. Might just run into the same autistics for the rest of my life (recurring theme).

I still try to best my LLM with my random niche knowledge but I think I will be done soon in most areas except for cryonics. A few months ago I asked who's the smartest Cantonese person and it gave me a list that didn't include Terence Tao.

@danfaggella Rare sane takes on this timeline

you think i am the only person in the world who believes: 1. man's timelines to destruction or transformation are short, and 2. we should ask how we can create a worthy successor to carry on beyond us but my DMs are basically just full of ppl who agree but can't voice it:

@yacineMTB @aloktiwari310 Calgary

@aloktiwari310 ottawa

montreal is actually bad for your soul man you can't live there for too long

I didn’t end up with the wordcel but I notice they do get a lot of attention from the ladies. I’ve dated philosophy bros many years ago.