Sc2.0

Thank you for highlighting this @TwistBioscience - hope you are keen on many more synthetic chromosome/genome projects!

A yeast strain with over 31% synthetic genome displays normal morphology and budding behavior >>> bit.ly/47pzsPr @CellPressNews @JefBoeke @caiyizhi @SynGenome

Scientists @BABlount @UoNLifeSci & @ProfTomEllis @Imperialcollege are poised to create the most advanced “synthetic” organism ever made — a baker’s yeast that is controlled entirely by human-made genetic instructions. Read more @thetimes ▶️ ow.ly/hTEb50Q6nZ9

Congrats to the Sc2.0 community on this huge achievement. Just wait for our Oxytricha trifallax 2.0!!

Now online! Design, construction, and functional characterization of a tRNA neochromosome in yeast dlvr.it/Syc6fM

We finally finished our synthetic chromosome! @ProfTomEllis @glen_gowers I'm just going to collapse in this corner now... cell.com/cell-genomics/…

A strain of yeast has had half its DNA replaced with artificial chromosomes in a major step towards creating the first complex cell with an entirely synthetic genome #Echobox=1699460354" target="_blank" rel="nofollow noopener">newscientist.com/article/240176…

Now online! Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions dlvr.it/SyZRQf

Researchers have achieved a significant milestone by successfully integrating more than seven synthetic chromosomes into a single yeast cell, yielding a strain with over 50% synthetic DNA that can survive and replicate similarly to wild yeast strains: synbiobeta.com/read/its-alive…

It’s a great pleasure to see the tRNA neochromosome finally reaching the light of day at @CellCellPress! I’m sharing co-first authorship with @DSchindler_PDR, with @caiyizhi at the helm and under the guidance of @JefBoeke. Find the article here: sciencedirect.com/science/articl…

Congratulations to all the consortium members for their hard work and contributions towards a landmark achievement in synthetic biology! @PaulsenLab @SynGenome

How do you build a synthetic yeast genome with thousands of designed changes and a new-to-nature genome diversification ‘scramble-ing’ mechanism?

Biologists have produced a strain of yeast whose genome is more than 50% synthetic DNA go.nature.com/3Qtp2a3

“Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast” @CellGenomics cell.com/cell-genomics/… @caiyizhi

“Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast” @cellcellpress cell.com/cell/fulltext/… @caiyizhi

#Yeast cell created with an over 50% synthetic #genome can survive and replicate similar to wild type. See below a collection of papers presenting this half-synthetic yeast and showcasing the #SyntheticYeastGenomeProject (Sc2.0) @yeastgenome 🧵

Very proud of our November issue presenting the amazing work by the Sc2.0 consortium. Took me back to my #igem (2006) roots and I know this collection will be a landmark in synthetic biology. cell.com/cell-genomics/…

Check it out now in #Cell #Genomics Open Access - Rise of synthetic #yeast: Charting courses to new applications community.alliancegenome.org/t/cellpress-op…

“Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains” @CellGenomics cell.com/cell-genomics/… @JohnsHopkinsSPH Srinivasan Chandrasegaran @JefBoeke @WEIMINZHANG6

An international team of scientists led by @caiyizhi are one step closer to re-writing world’s first synthetic yeast genome. The Sc2.0 team have now recreated every chromosome in baker's yeast from scratch and combined 6.5 of them in a functional cell. 👉manchester.ac.uk/discover/news/…