Therapeutic Advances in Infectious Disease

New systematic review & meta-analysis in SSA HCWs shows moderate AMR knowledge (65%) and attitudes (69%), but weaker practices (54%), with a clear knowledge–practice gap—most evident among doctors (knowledge 65%, practice 43%). journals.sagepub.com/doi/full/10.11…

Meet our Biostatistical Editor, Theophilus I. Emeto @ti_Emeto 📊 Featured today ! 👇 #InfectiousDiseases #Biostatistics #EditorialSpotlight

✨ Introducing our Editorial Spotlight Series 👀 Meet the people behind the science What motivates them 🚀 What inspires them 🌱 What brings them joy 🎶Because great work starts with real people ❤️Stay tuned as we highlight our team! #EditorialSpotlight

TB treatment is evolving—but persistence remains a major barrier. New evidence shows macrophage metabolism and redox state shape intracellular drug tolerance in Mtb. Host-directed strategies may enhance antibiotic efficacy and help shorten therapy ⏳ journals.sagepub.com/doi/full/10.11…

Case report: a young patient with years of “chronic lung disease” ultimately diagnosed with aggressive HTLV-1 driven lymphoma-fatal within weeks. Early biopsy + T-cell panel (CD4+CD25+ with CD7 loss) should trigger HTLV-1 testing, regardless of geography. journals.sagepub.com/doi/full/10.11…

CKD and UTIs form a vicious cycle: kidney dysfunction increases infection risk ; while recurrent UTIs accelerate renal decline. Breaking this loop demands early CKD detection, antimicrobial stewardship & non-antibiotic prevention strategies. journals.sagepub.com/doi/full/10.11…

Neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are valuable, readily available markers for gauging severity in community-acquired pneumonia 🦠📊 journals.sagepub.com/doi/10.1177/20…

Prospective study (Ukraine/Moldova/Spain, n=287): mfloDx™ MDR-TB assay achieved Se 100% / Sp 98.7% for INH+RIF resistance vs culture DST. Caveat: 35% inconclusive results. Potential role as rapid screening tool. journals.sagepub.com/doi/full/10.11…

Does EV-D68 amplify TB immunopathology? Case series suggests coinfection may worsen lung inflammation, with clinical response seen after corticosteroid escalation. A reminder to consider viral triggers in atypical TB courses. journals.sagepub.com/doi/10.1177/20…

Arboviruses don’t act in isolation 🦟 Chikungunya and Zika spread where structural vulnerabilities persist—limited surveillance, inequity, and inadequate sanitation. Future resilience depends on integrating social and biological surveillance systems 🧬.journals.sagepub.com/doi/10.1177/20…

Diagnosing invasive mold infections 🧫 in immunocompromised patients remains difficult.NGS 🧬 offers noninvasive, actionable insights-identifying missed infections and guiding therapy in over half of cases. journals.sagepub.com/doi/10.1177/20…

Malaria 🦟 + soil-transmitted helminths 🪱 often co-infect young children in Nigeria, driving early red cell changes 🩸 before overt anaemia. Host factors esp haemoglobin genotype 🧬matter more than parasite load. journals.sagepub.com/doi/10.1177/20…

New meta-analysis 📊: HBV escape mutations are common in LMICs 🧬 Immune escape ~56% 💊 Resistance highest with 3TC/LdT journals.sagepub.com/doi/full/10.11…

Case report: in HIV patient with recurrent Cryptocccal meningitis 🧠 despite virologic suppression, re-induction + isavuconazole led to immune recovery, viral control, and no further CM episodes over 6 months journals.sagepub.com/doi/full/10.11…

Chronic pulmonary aspergillosis + pulmonary embolism = a challenging duo 🫁🦠🩸Mechanisms may include inflammation + endothelial damage 🧬Management is tricky—anticoagulation vs hemoptysis risk ⚖️journals.sagepub.com/doi/full/10.11…

P: Mild COVID-19 pneumonia 🦠 I: Clarithromycin 800 mg/day 💊 C: Standard of care O: No significant change in time to 50% symptom improvement, but ↓ fatigue and ↓ inflammatory cytokines. Signals of immunomodulation worth further study. 🔬 journals.sagepub.com/doi/full/10.11…

Contingency management isn’t just for abstinence.A harm-reduction clinic for people who use drugs used incentives to encourage risk assessment, testing, clinic engagement to reduce HIV and infection risk.Early results show engagement among patients. journals.sagepub.com/doi/full/10.11…

In a survey of women in 🇿🇦 younger women& those engaged in transactional sex were more likely to intend to use PrEP, while condom users were less likely. #HIVPrevention #PrEP journals.sagepub.com/doi/full/10.11…

Strongyloides hyperinfection can occur without eosinophilia—even with CD4 >500 and undetectable HIV viral load. Early diagnosis is lifesaving ⚠️ journals.sagepub.com/doi/full/10.11…

Invasive pulmonary aspergillosis remains a lethal threat in immunocompromised and post-COVID patients 🦠 Advances in PCR, lateral flow assays, and immuno-PET/MRI are reshaping diagnosis, but rising azole resistance demands susceptibility testing journals.sagepub.com/doi/full/10.11…