Jim Hughes

Characterization of hereditary tumor risk in individuals with SDHA germline variants. | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…

Single Nuclei-Derived Molecular Subtypes of Gastrointestinal Stromal Tumors Correlate with Clinicopathologic Features and Predict Clinical Outcomes | bioRxiv biorxiv.org/content/10.110…

Genome‐Wide DNA Methylation and Copy Number Alterations in Gastrointestinal Stromal Tumors - Kleijn - 2025 - Genes, Chromosomes and Cancer - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/gc…

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles | Nature Communications #author-information" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

Recent Advances in Succinate Dehydrogenase Deficient Gastrointestinal Stromal Tumor Systemic Therapies | Current Treatment Options in Oncology link.springer.com/article/10.100…

A Review of Genomic Testing and SDH‐ Deficiency in Gastrointestinal Stromal Tumors: Getting to the GIST - Florou - 2025 - Cancer Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/ca…

Cracking the code of DNA circles in cancer, Stanford Medicine-led team uncovers potential therapy | News Center | Stanford Medicine med.stanford.edu/news/all-news/…

Autocrine IGF-II-Associated Cancers: From a Rare Paraneoplastic Event to a Hallmark in Malignancy mdpi.com/2227-9059/12/1…

Clinical characteristics of gastrointestinal stromal tumors with hypoglycemia spandidos-publications.com/10.3892/ol.202…

Kura Oncology Announces FDA Clearance of IND Application for Menin Inhibitor Ziftomenib in Advanced Gastrointestinal Stromal Tumors (GIST) | Kura Oncology, Inc. ir.kuraoncology.com/news-releases/…(GLOBEhttps://www.atlassian.com/software/confluence/comparison/confluence-vs-notion

Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation: Molecular Cell cell.com/molecular-cell…

"ClinVar currently has more than 3000 entries for VUS in SDHx genes." ... "Our findings open up new diagnostic options for the identification of carriers with SDHx PVs and could aid in classification of VUS in SDHx genes."

Identification of Succinate Dehydrogenase Gene Variant Carriers by Blood Biomarkers academic.oup.com/jes/article/8/…

Discontinuation versus continuation of imatinib in patients with advanced gastrointestinal stromal tumours (BFR14): exploratory long-term follow-up of an open-label, multicentre, randomised, phase 3 trial - The Lancet Oncology thelancet.com/journals/lanon…

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles - nihpp-rs4410500v1.pdf ncbi.nlm.nih.gov/pmc/articles/P…

Pre-clinical phaeochromocytoma and paraganglioma models: Cell lines, animal models, and a human primary culture model - ScienceDirect #tbl0005" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl… A map of pathogenic variants and currently available cell lines and primary cultures ... Figure 1

Adjuvant imatinib in high‐risk resected gastrointestinal stromal tumors: Merely delaying the inevitable? - Sutton - Journal of Surgical Oncology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/js…

A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors | Clinical Cancer Research | American Association for Cancer Research aacrjournals.org/clincancerres/…

Prevalence and prognosis of hypoxia‐inducible factor‐2α (HIF‐2α) pathway gene mutations across advanced solid tumors - CAM4-13-e7358.pdf ncbi.nlm.nih.gov/pmc/articles/P…

Targetable Receptor Tyrosine Kinase in Metastatic Pheochromocytoma and Paraganglioma: A Future Journey for Anlotinib? | Journal of the Endocrine Society | Oxford Academic academic.oup.com/jes/article/8/…