Michael Samuel

Great to see this work led by Bekky Feltham @WEHI_research and the global ubiquitin community now published. Happy to have contributed to the curation of HECT E3s.@CCB_Research The E3-ome gene-centric compendium reveals the human E3 ligase landsca... sciencedirect.com/science/articl…

@deniswirtz @DrSarahBoyle Thank you 🙏🏽

@TMEM_Samuel @DrSarahBoyle Great work. Congrats.

I am delighted to be able to share that our latest paper arising from a project co-led by @DrSarahBoyle and me is now out in the world, published in AAAS Science Advances: science.org/doi/10.1126/sc….

Thank you to all our lab members and colleagues who contributed to this research, and the funding bodies who supported our work: @hosp_research, @nhmrc @arc_gov_au , @WorldwideCancer

Sarah has a more detailed narrative of our findings here: x.com/DrSarahBoyle/s…

Why ‘being squeezed’ helps breast cancer cells to thrive “intense physical pressure at early stages of the disease… leaves a lasting ‘mechanical memory’ in breast cancer cells, promoting aggressive behaviour after the pressure itself has been relieved.” eurekalert.org/news-releases/…

We are very excited to share our newest results, published in Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory”. doi.org/10.1126/sciadv…

In a study co-led by myself and Prof @TMEM_Samuel at @CCB_Research, Adelaide University, we found breast cancer cells subjected to compression, such as experienced during tumour growth in the restricted mammary duct, are changed in ways that worsen the resulting tumours.

More on compression! @TMEM_Samuel @CCB_Research detailed how compressive stress from rapid mammary tumour growth triggers a Piezo1-dependent pathway that activates Rho-ROCK-mediated mechanosignaling contributing to a mechanical memory that drives cancer progression. #MBIMPG2025

Our lab is seeking a postdoctoral scientist to work with us on an exciting new project modelling cancer extracellular matrix structures using nanofabrication approaches. Full details are at shorturl.at/fF4OC.

brnw.ch/21wPsyJ Five UniSA projects awarded $5mill in @NHMRC grants announced today are set to improve cancer treatment, & help people prioritise their time building health

Summer is coming and so are the @CCB_Research @UniversitySA 2024/25 Vacation Scholarships for a 4-8 week research intensive in cancer biology!! There are also $100/week top ups kindly donated by the Fuss Family and @lashesofchange closes: 22 Sept 👇👇👇 #clinical-health" target="_blank" rel="nofollow noopener">unisa.edu.au/research/degre…

Our colleague @s_pitson at @CCB_Research @UniversitySA will be trekking the Kakoda Trail in October raising funds for @NeuroSurgRF, particularly for an important research project led by A/Prof. Quenten Schwarz to find better treatments for children with brain cancers.

@SamStehbens @robertr33 @arc_gov_au @drDJVDavid @NatureCellBio Congratulations, @SamStehbens! Great to see this beautiful story out in the world :)

Excited to announce…..it’s finally arrived (!!) nature.com/articles/s4155… A big thank-you to my team (particularly @robertr33), co authors & #FutureFellowship funding from @arc_gov_au Importantly- a big shoutout to @drDJVDavid @NatureCellBio for their support. 👇tweetorial 👇 #VivaLaMicrotubules 🎉

We are excited to announce the 12th ANZSCDB South Australia meeting taking place on October 16, 2024! Join us for insightful talks from @McGlinnLab, @CedricBardyLab, and @Lisa_M_Nic at @unisa. Don't miss this packed event! #devbio #science #cellbiology

Another exciting #openaccess paper in #cytoskeleton @CytoskelJournal Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell #carcinoma onlinelibrary.wiley.com/doi/full/10.10… @TMEM_Samuel #cancer #science #cell #cellbiology